Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David B. Zhen"'
Autor:
David B. Zhen, Rachael A. Safyan, Eric Q. Konick, Ryan Nguyen, Colin C. Prichard, E. Gabriela Chiorean
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 16 (2023)
Pancreatic ductal adenocarcinoma (PDA) is highly aggressive and has few treatment options. To personalize therapy, it is critical to delineate molecular subtypes and understand inter- and intra-tumoral heterogeneity. Germline testing for hereditary g
Externí odkaz:
https://doaj.org/article/fb652e64f16d4f0a91f3368c72bba34c
Autor:
Arathi Mohan, Kent A. Griffith, Fulei Wuchu, David B. Zhen, Chandan Kumar-Sinha, Oxana Crysler, David Hsiehchen, Thomas Enzler, Dominique Dippman, Valerie Gunchick, Abhinav Achreja, Olamide Animasahun, Srinadh Choppara, Minal Nenwani, Arul M. Chinnaiyan, Deepak Nagrath, Mark M. Zalupski, Vaibhav Sahai
Publikováno v:
Clinical Cancer Research. :OF1-OF7
Purpose: Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC). Patients and Methods: Cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a45a60cde5496ea710ec91e749d00c
https://doi.org/10.1158/1078-0432.ccr-23-0036
https://doi.org/10.1158/1078-0432.ccr-23-0036
Autor:
Vaibhav Sahai, Mark M. Zalupski, Deepak Nagrath, Arul M. Chinnaiyan, Minal Nenwani, Srinadh Choppara, Olamide Animasahun, Abhinav Achreja, Valerie Gunchick, Dominique Dippman, Thomas Enzler, David Hsiehchen, Oxana Crysler, Chandan Kumar-Sinha, David B. Zhen, Fulei Wuchu, Kent A. Griffith, Arathi Mohan
Genomics data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf71ed6fa0c36668564aa3b1798ee54
https://doi.org/10.1158/1078-0432.22893694
https://doi.org/10.1158/1078-0432.22893694
Autor:
Vaibhav Sahai, Mark M. Zalupski, Deepak Nagrath, Arul M. Chinnaiyan, Minal Nenwani, Srinadh Choppara, Olamide Animasahun, Abhinav Achreja, Valerie Gunchick, Dominique Dippman, Thomas Enzler, David Hsiehchen, Oxana Crysler, Chandan Kumar-Sinha, David B. Zhen, Fulei Wuchu, Kent A. Griffith, Arathi Mohan
Study Schema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9a39654b76890d99f403e092574ed9
https://doi.org/10.1158/1078-0432.22893718
https://doi.org/10.1158/1078-0432.22893718
Autor:
Vaibhav Sahai, Mark M. Zalupski, Deepak Nagrath, Arul M. Chinnaiyan, Minal Nenwani, Srinadh Choppara, Olamide Animasahun, Abhinav Achreja, Valerie Gunchick, Dominique Dippman, Thomas Enzler, David Hsiehchen, Oxana Crysler, Chandan Kumar-Sinha, David B. Zhen, Fulei Wuchu, Kent A. Griffith, Arathi Mohan
Purpose:Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC).Patients and Methods:Cell v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0374e893a424ba7ff0be807f6b66b20
https://doi.org/10.1158/1078-0432.c.6651163.v1
https://doi.org/10.1158/1078-0432.c.6651163.v1
Publikováno v:
Expert review of clinical immunology. 18(11)
Immune checkpoint inhibitors (ICI) have not yielded significant efficacy in pancreatic ductal adenocarcinoma (PDA), despite the role of the innate and adaptive immune systems on progression and survival. However, recently identified pathways have ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d137f01142acabd898287e4671a9b842
https://pubmed.ncbi.nlm.nih.gov/36045547
https://pubmed.ncbi.nlm.nih.gov/36045547
Autor:
Vaibhav Sahai, Kent A. Griffith, Muhammad S. Beg, Walid L. Shaib, Devalingam Mahalingam, David B. Zhen, Dustin A. Deming, Mark M. Zalupski
Publikováno v:
Cancer. 128(19)
Gemcitabine and cisplatin has limited benefit as treatment for advanced biliary tract cancer (BTC). The addition of an anti-programmed death receptor (PD-1)/PD-ligand (L1) antibody to either systemic chemotherapy or anti-cytotoxic T-lymphocyte-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6450e41ead9d3f9d625ba63e1770fd10
https://pubmed.ncbi.nlm.nih.gov/35895381
https://pubmed.ncbi.nlm.nih.gov/35895381
Autor:
Efrat Dotan, Paul Catalano, Leon Lenchik, Robert Boutin, Xin Yao, Helga S. Marques, Dina Ioffe, David B. Zhen, Daneng Li, Lynne I. Wagner, Melissa A. Simon, Terence Z. Wong, Peter J. O'Dwyer
Publikováno v:
Journal of Geriatric Oncology. 14:101474
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528bbf7d92574b2f838c03fee00b5225
https://doi.org/10.1016/j.jgo.2023.101474
https://doi.org/10.1016/j.jgo.2023.101474
Autor:
Kohei Shitara, Haeseong Park, Tanios Bekaii-Saab, Sunnie S. Kim, Suneel Kamath, Michael J. Pishvaian, Christopher Chen, David B. Zhen, Joal Mayor, Qianwen Tan, John H. Strickler
Publikováno v:
Annals of Oncology. 33:S502
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b279ba0e11aacc4c4766e8cd4b3134fe
https://doi.org/10.1016/j.annonc.2022.05.183
https://doi.org/10.1016/j.annonc.2022.05.183
Publikováno v:
Seminars in Oncology. 45:107-115
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with few effective treatment options. Our knowledge of molecular alterations in PDAC has significantly grown and helped identify new therapeutic targets. The success of immune checkpoin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ea5e85f2aca32ad00fb96c84074b3d
https://doi.org/10.1053/j.seminoncol.2018.05.004
https://doi.org/10.1053/j.seminoncol.2018.05.004