Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David B. Winter"'
Publikováno v:
Molecular Immunology. 44:2800-2805
Immunoglobulin variable genes undergo several unusual genetic modifications to generate diversity, such as gene rearrangement, gene conversion, somatic hypermutation, and heavy chain class switch recombination. In view of these specialized processes,
Autor:
Josef Thalhamer, George C. Tsokos, Richard Weiss, David B. Winter, Evelina Angov, Elizabeth H. Duncan, Farhat Khan, Jeffrey A. Lyon, Jackie L. Williams, Wolfgang W. Leitner, Elke S. Bergmann-Leitner, Sandra Scheiblhofer, Defeng Chen
Publikováno v:
International Immunology. 17:245-255
The immunogenicity of recombinant protein or anti-viral DNA vaccines can be significantly improved by the addition of tandem copies of the complement fragment C3d. We sought to determine if the efficacy of a circumsporozoite protein (CSP)-based DNA v
Autor:
David B. Winter, Patricia J. Gearhart, Quy H. Phung, Deborah E. Barnes, Xianmin Zeng, Erling Seeberg, Tomas Lindahl
Publikováno v:
The Journal of Immunology. 170:5558-5562
The hypermutation cascade in Ig V genes can be initiated by deamination of cytosine in DNA to uracil by activation-induced cytosine deaminase and its removal by uracil-DNA glycosylase. To determine whether damage to guanine also contributes to hyperm
Autor:
Vilhelm A. Bohr, Gunhild Lange Skovgaard, Karli Rosner, Patricia J. Gearhart, Robert E. Tarone, David B. Winter
Publikováno v:
Immunology. 103:179-187
The third complementarity-determining region (CDR3) of immunoglobulin variable genes for the heavy chain (VH) has been shown to be shorter in length in hypermutated antibodies than in non-hypermutated antibodies. To determine which components of CDR3
Autor:
Kenneth H. Kraemer, Alan R. Lehmann, Xianmin Zeng, Patricia J. Gearhart, David B. Winter, Cynthia Kasmer
Publikováno v:
Nature Immunology. 2:537-541
To determine whether DNA polymerase plays a role in the hypermutation of immunoglobulin variable genes, we examined the frequency and pattern of substitutions in variable VH6 genes from the peripheral blood lymphocytes of three patients with xeroderm
Autor:
David B. Winter, Patricia J. Gearhart
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 356:5-11
Affinity maturation of the humoral immune response is based on the ability of immunoglobulin variable genes to undergo a process of rapid and extensive somatic mutation followed by antigenic selection for antibodies with higher affinity. While the be
Autor:
Robert E. Tarone, Karli Rosner, Patricia J. Gearhart, Cynthia Kasmer, David B. Winter, Vilhelm A. Bohr, Gunhild Lange Skovgaard
Publikováno v:
Journal of Clinical Immunology. 21:102-115
Chronological aging is associated with an accumulation of DNA mutations that results in cancer formation. The effect of aging on spontaneous mutations in humans is difficult to study because mutations are infrequent in the overall genome and tumors a
Publikováno v:
The Journal of Immunology. 162:3121-3124
During somatic hypermutation of Ig V genes, mismatched nucleotide substitutions become candidates for removal by the DNA mismatch repair pathway. Previous studies have shown that V genes from mice deficient for the MSH2 and PMS2 mismatch repair prote
Autor:
Quy H. Phung, Patricia J. Gearhart, Robert E. Tarone, David B. Winter, Vilhelm A. Bohr, Aaron Cranston, Richard Fishel
Publikováno v:
The Journal of Experimental Medicine
Rearranged immunoglobulin variable genes are extensively mutated after stimulation of B lymphocytes by antigen. Mutations are likely generated by an error-prone DNA polymerase, and the mismatch repair pathway may process the mispairs. To examine the
Autor:
Karli Rosner, David B. Winter, Gunhild Lange Skovgaard, Junko Oshima, Patricia J. Gearhart, Vilhelm A. Bohr
Publikováno v:
Mechanisms of ageing and development. 122(11)
Werner syndrome (WS) is a human premature aging syndrome, which is associated with high frequencies of neoplasia and genetic instability. We have examined the occurrence of microsatellite instability, which may result from defective mismatch repair,