Zobrazeno 1 - 10
of 98
pro vyhledávání: '"David B. Thompson"'
Autor:
Yong Tao, Veronica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N. Whittaker, John A. Zuris, David B. Thompson, Arun Prabhu Rameshbabu, Yilai Shu, Xue Gao, Johnny H. Hu, Charles Pei, Wei-Jia Kong, Xuezhong Liu, Hao Wu, Benjamin P. Kleinstiver, David R. Liu, Zheng-Yi Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mutations in Atp2b2, an outer hair cell gene, cause dominant hearing loss in humans. Using a mouse model Atp2b2 Obl/+, with a dominant hearing loss mutation (Oblivion), we show that liposome-mediated in vivo delivery of CRISPR-Cas9 ribonucle
Externí odkaz:
https://doaj.org/article/a29936b8a683497cbbd1b953799336a4
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Inefficient delivery of proteins into mammalian cells limits their use in research and therapy. Here, the authors discover that ProTα, a small, intrinsically disordered human protein can facilitate efficient cationic lipid-mediated protein delivery
Externí odkaz:
https://doaj.org/article/c835099de4814592bcbecee8ffae3aee
Autor:
Jeffrey L. Bessen, Lena K. Afeyan, Vlado Dančík, Luke W. Koblan, David B. Thompson, Chas Leichner, Paul A. Clemons, David R. Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The development of site-specific recombinases as genome editing tools is limited by the difficulty of altering their DNA sequence specificity. Here the authors present Rec-seq, a method for identifying specificity determinants and off-target substrat
Externí odkaz:
https://doaj.org/article/cab979859ad4417b8ff4c6496b54b8cd
Autor:
Jeffrey L. Bessen, Lena K. Afeyan, Vlado Dančík, Luke W. Koblan, David B. Thompson, Chas Leichner, Paul A. Clemons, David R. Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-3 (2019)
Externí odkaz:
https://doaj.org/article/d9b0668567fe4179adfb2a8f5e45443f
Autor:
Donghyun Lim, Qingxuan Zhou, Kurt J. Cox, Benjamin K. Law, Miseon Lee, Praveen Kokkonda, Vedagopuram Sreekanth, Rajaiah Pergu, Santosh K. Chaudhary, Soumyashree A. Gangopadhyay, Basudeb Maji, Sophia Lai, Yuka Amako, David B. Thompson, Hari K. K. Subramanian, Michael F. Mesleh, Vlado Dančík, Paul A. Clemons, Bridget K. Wagner, Christina M. Woo, George M. Church, Amit Choudhary
Publikováno v:
Nat Cell Biol
The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule inhibitor discovery platforms available at present are not generalizable to multiple nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fc6b03b4a9c93d1ffd988021f853ba
https://doi.org/10.1038/s41556-022-01005-8
https://doi.org/10.1038/s41556-022-01005-8
Autor:
Nick Barry, Roey Lazarovits, Tal Gilboa, Limor Cohen, Augusta Uwamanzu-Nna, Richie E. Kohman, Ann E. Woolley, Chi-An Cheng, David B. Thompson, Elizabeth W. Karlson, Kettner Griswold, David R. Walt, Isaac Han
Publikováno v:
Angewandte Chemie (International Ed. in English)
Coronavirus disease 2019 (COVID‐19) manifests with high clinical variability and warrants sensitive and specific assays to analyze immune responses in infected and vaccinated individuals. Using Single Molecule Arrays (Simoa), we developed an assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99514550b758d6988b2ed2dc9f585e6a
https://doi.org/10.1002/anie.202110702
https://doi.org/10.1002/anie.202110702
Autor:
Xiao Tan, F Ann Ran, Nathaniel D. Tippens, James J. Collins, Emma J. Chory, Evan M. Zhao, Crystal Yuri Oh, Angelo S. Mao, Eric S Zigon, Tiffany Y Hua, Kehan Zhang, Pradeep Ramesh, David B. Thompson, Peter Q. Nguyen, Isaac Han, Max A English, Helena de Puig
Publikováno v:
Nature Biotechnology. 40:539-545
The ability to control translation of endogenous or exogenous RNAs in eukaryotic cells would facilitate a variety of biotechnological applications. Current strategies are limited by low fold changes in transgene output and the size of trigger RNAs (t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97bca9ee11231ead3d8b1dff78b96db8
https://doi.org/10.1038/s41587-021-01068-2
https://doi.org/10.1038/s41587-021-01068-2
Autor:
Yves Sabbagh, Angela Lynch, Zhiliang Cheng, Denis J. Schrier, Caitlin Sullivan, Steven Jungles, David B. Thompson, Kevin O'Brien, Jennifer Howe
Publikováno v:
Journal of Bone and Mineral Research. 36:1594-1604
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity. Loss-of-function m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b420d51654cc933f32d70df0739c4e72
https://doi.org/10.1002/jbmr.4315
https://doi.org/10.1002/jbmr.4315
Autor:
Massimo Merighi, Natalie J. Ma, Mark Simon, Christopher E. Mason, Mikhail Y. Wolfson, Vinitra Nathan, Jacob L. Swett, Pamela A. Silver, Marika Ziesack, David B. Thompson, Shannon N. Nangle, Lucas A Hartsough
Publikováno v:
Nature Biotechnology. 38:401-407
The stepwise application of biotechnology will be instrumental to addressing four key challenges of Martian settlement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aca52d639bb829690183671c2c3c67c
https://doi.org/10.1038/s41587-020-0485-4
https://doi.org/10.1038/s41587-020-0485-4
Autor:
Thomas O. Carpenter, Björn Busse, Dillon Kavanagh, Simon von Kroge, Paul R. Stabach, Demetrios T. Braddock, Mark C. Horowitz, Thorsten Schinke, Nathan D. Maulding, Michael Amling, Kristin Zimmerman, Ralf Oheim, Uwe Kornak, Steven M. Tommasini, Julian Stürznickel, David B. Thompson
Publikováno v:
Journal of Bone and Mineral Research
Biallelic ENPP1 deficiency in humans induces generalized arterial calcification of infancy (GACI) and/or autosomal recessive hypophosphatemic rickets type 2 (ARHR2). The latter is characterized by markedly increased circulating FGF23 levels and renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92db213f9da2d812051d54baf029d6c2
https://doi.org/10.1002/jbmr.3911
https://doi.org/10.1002/jbmr.3911