Zobrazeno 1 - 10
of 42
pro vyhledávání: '"David B. Strasfeld"'
Autor:
Lynne Clark, Barbara L. Smith, Stephen E. Karp, Katherine Clegg Smith, Irene Wapnir, Sean Madden, Peter D. Beitsch, Stephanie A. Valente, W. David Lee, Donna Lynn Dyess, Nayana Dekhne, Beth-Ann Lesnikoski, Jorge Ferrer, Anees B. Chagpar, Peter W. Blumencranz, Kelly K. Hunt, David Carr, Brian Schlossberg, S Hwang, Linsey Gold, Daleela Dodge, Manna Chang, David B. Strasfeld
Publikováno v:
Cancer Research. 80:P1-20
Background: Standard surgical techniques result in positive lumpectomy margins 20-40% of the time. These positive margins require surgical re-excision which places significant burden on the healthcare system and patients. The LUM Imaging System consi
Autor:
Barbara L. Smith, Upahvan Rai, Elena F. Brachtel, Bridget N. Kelly, Anna Biernacka, Conor R. Lanahan, Carson Brown, David B. Strasfeld, Rong Tang, Michelle C. Specht, Michele A. Gadd, Travis Rice-Stitt, Jorge Ferrer
Publikováno v:
Ann Surg Oncol
Annals of Surgical Oncology
Annals of Surgical Oncology
Background Obtaining tumor-free margins is critical to prevent recurrence after lumpectomy for breast cancer. Unfortunately, current approaches leave positive margins that require second surgeries in 20–40% of patients. We assessed the LUM Imaging
Autor:
Jenna L. Mueller, Nimmi Ramanujam, Suzanne Bartholf DeWitt, Melodi Javid Whitley, David G. Kirsch, David B. Strasfeld, Henry L. Fu, Alexander L. Lazarides, Jorge Ferrer, William C. Eward, Brian E. Brigman, Diana M. Cardona
Publikováno v:
Theranostics
The treatment of soft tissue sarcoma (STS) generally involves tumor excision with a wide margin. Although advances in fluorescence imaging make real-time detection of cancer possible, removal is limited by the precision of the human eye and hand. Her
Autor:
Anna Biernacka, Barbara L. Smith, Conor R. Lanahan, David B. Strasfeld, Jorge Ferrer, Michelle C. Specht, Upahvan Rai, Bridget N. Kelly, Michele A. Gadd, Rong Tang, Elena F. Brachtel, Travis Rice-Stitt, Carson Brown
Publikováno v:
Annals of Surgical Oncology. 27:967-967
Autor:
Michele A. Gadd, Conor R. Lanahan, Jorge Ferrer, Rong Tang, Elena F. Brachtel, David B. Strasfeld, Barbara L. Smith, Andrea L. Merrill, Michelle C. Specht, Travis Rice-Stitt, Upahvan Rai
Publikováno v:
Breast cancer research and treatment. 171(2)
Obtaining tumor-free surgical margins is critical to prevent recurrence in breast-conserving surgery but it remains challenging. We assessed the LUM Imaging System for real-time, intraoperative detection of residual tumor. Lumpectomy cavity walls and
A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer
Autor:
William C. Eward, Rachel A. Greenup, Chang-Lung Lee, Rakesh K. Jain, Matija Snuderl, Moungi G. Bawendi, E. Shelley Hwang, Ivan Spasojevic, W. David Lee, Melodi Javid Whitley, Dan G. Blazer, Alexander L. Lazarides, Joan Cahill, Erin K. O'Reilly, Paul J. Mosca, Richard F. Riedel, David G. Kirsch, Jeffrey K. Mito, Linda G. Griffith, Kyle C. Cuneo, David B. Strasfeld, Jorge Ferrer, Dai Fukumura, Brian E. Brigman, Diana M. Cardona, Nicole A. Larrier
Publikováno v:
PMC
Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor bed could be used to decrease the risk of a positive surgical margin, reduce rates of reexcis
Autor:
Allam S. Reddy, Chris T. Middleton, Juan J. de Pablo, David B. Strasfeld, Martin T. Zanni, James L. Skinner, Peter Marek, Sadanand Singh, Ann Marie Woys, Daniel P. Raleigh, Lu Wang
Publikováno v:
Journal of the American Chemical Society. 133:16062-16071
The aggregation of human amylin to form amyloid contributes to islet β-cell dysfunction in type 2 diabetes. Studies of amyloid formation have been hindered by the low structural resolution or relatively modest time resolution of standard methods. Tw
Publikováno v:
Vibrational Spectroscopy. 50:136-142
Two-dimensional infrared spectroscopy is a powerful tool for studying molecular structure and kinetics. However, standard ways of implementing the technique are not amenable to samples with high optical densities. In this paper, we demonstrate that a
Autor:
Yun L. Ling, David B. Strasfeld, Martin T. Zanni, Ruchi Gupta, Sang Hee Shim, Daniel P. Raleigh
Publikováno v:
Proceedings of the National Academy of Sciences. 106:6614-6619
There is considerable interest in uncovering the pathway of amyloid formation because the toxic properties of amyloid likely stems from prefibril intermediates and not the fully formed fibrils. Using a recently invented method of collecting 2-dimensi
Publikováno v:
The Journal of Physical Chemistry B. 113:2498-2505
Islet amyloid polypeptide (IAPP, also known as amylin) is responsible for pancreatic amyloid deposits in type 2 diabetes. The deposits, as well as intermediates in their assembly, are cytotoxic to pancreatic beta-cells and contribute to the loss of b