Výsledky vyhledávání - "David B. Stong"

Two-year carcinogenicity studies with the oral direct thrombin inhibitor ximelagatran in the rat and the mouse

Autor: Guy Healing, Stefan Carlsson, Inger Skånberg, David B. Stong, Ronny Fransson-Steen, Sivert Bjurström

Publikováno v: International journal of toxicology. 31(4)

The results of 18 months mouse and 24 months rat carcinogenicity studies with the oral direct thrombin inhibitor ximelagatran are presented. In the mouse, gavage doses of ximelagatran up to 180 μmol/kg per d produced no neoplastic changes in any of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586c97c0fb6cf78ee1f85e32204b1a9c
https://pubmed.ncbi.nlm.nih.gov/22692977

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Assessment of biomarkers of drug-induced kidney injury in cynomolgus monkeys treated with a triple reuptake inhibitor

Autor: Sally A. Price, Annabelle Heier, David B. Stong, Mausumee Guha, Thomas R. Simpson, Margareta Bielenstein, Daniel I. Heathcote, Elmarie Bodes, Robert Caccese

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 120(2)

Drug-induced kidney injury (DIKI) results in attrition during drug development; new DIKI urinary biomarkers offer potential to detect and monitor DIKI progression and regression, but frequently only in rats. The triple reuptake inhibitor (TRI) PRC200

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4856a88777c7c363fad8e1907a53572
https://pubmed.ncbi.nlm.nih.gov/21258088

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N-methylation reduces the DNA-binding activity of 7H-dibenzo[c,g]carbazole ∼300-fold in mouse liver but only ∼2-fold in skin: possible correlation with carcinogenic activity

Autor: Mark E. Schurdak, Kurt Randerath, David B. Stong, David Warshawsky

Publikováno v: Carcinogenesis. 8:1405-1410

N-methyl-dibenzo[c,g]carbazole (MeDBC) lacks the potent hepatocarcinogenic activity in mice characteristic for 7H-dibenzo[c,g]carbazole (DBC), while both compounds are local carcinogens, leading to papilloma and carcinoma formation in skin after topi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d685f4c83a4b38804732c731936c019
https://doi.org/10.1093/carcin/8.10.1405

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The metabolism of dibenz[a,j]acridine in the isolated perfused lung

Autor: Lois Hollingsworth, David B. Stong, David Warshawsky, Raymond Reilman

Publikováno v: Cancer letters. 28(3)

The metabolism of the carcinogenic N -heterocyclic aromatic, dibenz[ a,j ]acridine (DB[ a,j ]A), was investigated in an isolated perfused rabbit lung preparation. The rate of metabolism of DB[ a,j ]A was less than the rate of metabolism of 7 H -diben

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1ba60501494dedfeb90b4f55219810
https://pubmed.ncbi.nlm.nih.gov/4053001

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32P-postlabeling analysis of DNA adduction in mice by synthetic metabolites of the environmental carcinogen, 7H-dibenzo[c,g]carbazole: chromatographic evidence for 3-hydroxy-7H-dibenzo[c,g]carbazole being a proximate genotoxicant in liver but not skin

Autor: David Warshawsky, David B. Stong, Kurt Randerath, Mark E. Schurdak

Publikováno v: Carcinogenesis. 8(4)

The DNA adduction by the environmental carcinogen 7H-dibenzo[c,g]carbazole (DBC) and chemically synthesized 2-OH, 3-OH, and 4-OH metabolites of DBC was investigated in liver and skin of female CD-1 mice. After topical application to the skin of 37 mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53e579bc032aae58d95746fb36ac2a9
https://pubmed.ncbi.nlm.nih.gov/3829321

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The chemistry and biology of 7H-dibenzo[c,g]carbazole: synthesis and characterization of selected derivatives, metabolism in rat liver preparations and mutagenesis mediated by cultured rat hepatocytes

Autor: David Warshawsky, Robert T. Christian, R. Marshall Wilson, David B. Stong, Koka Jayasimhulu

Publikováno v: Carcinogenesis. 10(3)

Authentic stable standards of 7H-dibenzo[c,g]carbazole (DBC), a potent environmental carcinogen, were synthesized in order to study the compound's metabolism and mutagenesis in whole cell systems. Complete characterization of 2-OH-DBC, 3-OH-DBC, 4-OH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2eb012b7b985c2796eee15a2b70125c
https://pubmed.ncbi.nlm.nih.gov/2924389

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