Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David B. Smithrud"'
Autor:
Lucas A. Powers, David B. Smithrud
Publikováno v:
Molecules, Vol 21, Iss 8, p 1043 (2016)
Rotaxanes are unique mechanical devices that hold great promise as sensors. We report on two new rotaxanes that contain an acid or base sensitive trigger and readily disassemble in a wide range of environments. Disassemblage was observed under TLC an
Externí odkaz:
https://doaj.org/article/f42619a0688444e7b77111d8aca9cccc
Autor:
Yanjun Jiang, Meenasri Kumbaji, Amber M. D'Souza, Sheeniza Shah, Leila Valanejad, Ashley Cast, Rebekah Karns, Mary Wright, David B. Smithrud, Soona Shin, Kyle Lewis, Nikolai A. Timchenko
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 239-255 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 239-255 (2018)
Background & Aims Uncontrolled liver proliferation is a key characteristic of liver cancer; however, the mechanisms by which this occurs are not well understood. Elucidation of these mechanisms is necessary for the development of better therapy. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a827d10be77fd53d2b878a033f12355
https://doi.org/10.1016/j.jcmgh.2018.05.007
https://doi.org/10.1016/j.jcmgh.2018.05.007
Autor:
Allan R. Pinhas, David B. Smithrud
Publikováno v:
Journal of Chemical Education. 92:1965-1970
For the past eight years, we have used online homework software as a pedagogical tool for undergraduate students (almost all are second-year students) learning organic chemistry. Being strong proponents of homework, we were surprised to find that abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc75cd90575f3669aa515c01c1605fc
https://doi.org/10.1021/ed500594g
https://doi.org/10.1021/ed500594g
Autor:
David B. Smithrud, Lucas Powers
Publikováno v:
Molecules, Vol 21, Iss 8, p 1043 (2016)
Molecules; Volume 21; Issue 8; Pages: 1043
Molecules
Molecules; Volume 21; Issue 8; Pages: 1043
Molecules
Rotaxanes are unique mechanical devices that hold great promise as sensors. We report on two new rotaxanes that contain an acid or base sensitive trigger and readily disassemble in a wide range of environments. Disassemblage was observed under TLC an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5fe5c48eb1e4316d30dd022e86aa97
http://www.mdpi.com/1420-3049/21/8/1043
http://www.mdpi.com/1420-3049/21/8/1043
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5058-5062
A cleft-[2]rotaxane (CR2+2-) was derivatized with carboxylic acids to enhance the intracellular delivery of a highly cationic or anionic pentapeptide. CR2+2- delivers the fluorescein (Fl) tagged peptide Fl-KKALR to a greater amount than Fl-QEAVD, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27ce4848f0b01bb69ea465b2fb92aa6
https://doi.org/10.1016/j.bmcl.2007.07.013
https://doi.org/10.1016/j.bmcl.2007.07.013
Autor:
David B. Smithrud, Xiaoyang Wang, Xiaofeng Bao, Molly M. McFarland-Mancini, and Angela F. Drew, Idit Isaacsohn
Publikováno v:
Journal of the American Chemical Society. 129:7284-7293
The development of methods to transport peptides into cells via a passive mechanism would greatly aid in the development of therapeutic agents. We recently demonstrated that an impermeable fluoresceinated pentapeptide enters the cytoplasm and nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cb6f1a776e32e905fb2cd0a7adca68
https://doi.org/10.1021/ja067928x
https://doi.org/10.1021/ja067928x
Autor:
Jeffrey A. Turk, David B. Smithrud
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:2355-2365
A peptidomimetic template, consisting of a hydrophobic scaffold, a dansyl fluorophore, and an Arg-His recognition strand, was tested as a simple mimic of zinc finger 2 of the Zif268 protein. Association constants (KA's) were on the order of 105 M−1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e4e59447fc0bb7da090e536b974b72
https://doi.org/10.1016/s0968-0896(02)00646-6
https://doi.org/10.1016/s0968-0896(02)00646-6
Publikováno v:
The Journal of Organic Chemistry. 68:2559-2571
A host−[2]rotaxane was constructed by converting a diaminophenylcalix[4]arene into a [2]rotaxane using the DCC-rotaxane method (Zehnder, D.; Smithrud, D. B. Org. Lett. 2001, 16, 2485−2486). N-Ac-Arg groups were attached to the dibenzo-24-crown-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109d1ea0fd11991e156d2a14d9cd65d8
https://doi.org/10.1021/jo026522+
https://doi.org/10.1021/jo026522+
Autor:
Jeffrey A. Turk, David B. Smithrud
Publikováno v:
The Journal of Organic Chemistry. 66:8328-8335
A series of mimetic cores composed of a synthetic scaffold and amino acids have been constructed and their properties investigated in chloroform. A relative measure of H-bond strength was obtained by comparing temperature coefficients derived from va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4119dead1b549a21ce27ff2f6a1b7c
https://doi.org/10.1021/jo0106849
https://doi.org/10.1021/jo0106849
Autor:
Inese Smukste, David B. Smithrud
Publikováno v:
Tetrahedron. 57:9555-9561
In this report, we describe a convenient method to create neutrally charged, water soluble calix[4]arenes that contain hydroxyamides attached to their lower rims. Selective amidation reactions of a diacid calix[4]arene with several unprotected hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313c92de0ba1cf907262c0954c50caf3
https://doi.org/10.1016/s0040-4020(01)00965-6
https://doi.org/10.1016/s0040-4020(01)00965-6