Zobrazeno 1 - 10
of 51
pro vyhledávání: '"David B. Shaw"'
Publikováno v:
Psychiatric Rehabilitation Journal. 44:365-372
OBJECTIVE The inclusion of peer-delivered services in organizations providing behavioral health care has significantly increased in recent years, and substantial resources are being directed toward implementing recovery-oriented mental health service
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a821f4928c441eb7848933be91d6599f
https://doi.org/10.1037/prj0000482
https://doi.org/10.1037/prj0000482
Autor:
Alberto Galbusera, Gary Gilmour, Carola Canella, David B. Shaw, Andrew McCarthy, Daniel Gutierrez-Barragan, Keith A. Wafford, Christian C. Felder, Alessandro Gozzi, David L. McKinzie, Adam J. Schwarz, Caterina Montani, Karen M. Knitowski, Jennifer Li
Publikováno v:
Neuropsychopharmacology
Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances, or psychosis, such as Alzheimer's disease or schizophrenia. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ef9942a3f22055f767f8435ac9b60e
https://pubmed.ncbi.nlm.nih.gov/33342996
https://pubmed.ncbi.nlm.nih.gov/33342996
Autor:
Gary Gilmour, Alberto Galbusera, Andrew McCarthy, David L. McKinzie, Adam J. Schwarz, Jennifer Li, Keith A. Wafford, Christian C. Felder, Carola Canella, Karen M. Knitowski, Alessandro Gozzi, David B. Shaw, Caterina Montani
Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances or psychosis, such as Alzheimer’s disease or schizophrenia. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8436f95b1e8842ebed711e47c006fc5e
Autor:
Frances Lu, Bryan G. Johnson, Daniel Ursu, Joan H. Carter, Lisa M. Broad, Kofi Adragni, Shane Atwell, Jing Wang, David K. Clawson, Beverly A. Heinz, Steven P. Swanson, James A. Monn, Qi Chen, Helene E. Sanger, David B. Shaw, Steven Marc Massey, Xushan Wang, Marijane Russell, Steven S. Henry, Junliang Hao, Rajni M. Bhardwaj, Diseroad Benjamin Alan, David L. McKinzie, Brian G. Getman, John T. Catlow
Publikováno v:
Journal of Medicinal Chemistry. 61:2303-2328
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu3) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify potent, selective, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fd3a986aac486e41e6ea738f1a4465
https://doi.org/10.1021/acs.jmedchem.7b01481
https://doi.org/10.1021/acs.jmedchem.7b01481
Autor:
James A, Monn, Steven S, Henry, Steven M, Massey, David K, Clawson, Qi, Chen, Benjamin A, Diseroad, Rajni M, Bhardwaj, Shane, Atwell, Frances, Lu, Jing, Wang, Marijane, Russell, Beverly A, Heinz, Xu-Shan, Wang, Joan H, Carter, Brian G, Getman, Kofi, Adragni, Lisa M, Broad, Helene E, Sanger, Daniel, Ursu, John T, Catlow, Steven, Swanson, Bryan G, Johnson, David B, Shaw, David L, McKinzie, Junliang, Hao
Publikováno v:
Journal of medicinal chemistry. 61(6)
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b0a91b923b376e1620dd4223a841b23
https://pubmed.ncbi.nlm.nih.gov/29350927
https://pubmed.ncbi.nlm.nih.gov/29350927
Autor:
Mark G. Bures, David Edward Tupper, Joan H. Carter, James A. Monn, David L. McKinzie, Marijane Russell, Lourdes Prieto, Steven S. Henry, Reinhard Matthew Robert, Alicia Marcos, Lesley Walton, Christopher David Beadle, Bryan G. Johnson, Brian G. Getman, John T. Catlow, Frances Lu, Xushan Wang, Lorena Taboada, S. Richard Baker, Beverly A. Heinz, Helene Rudyk, David B. Shaw, Jaime Blanco, Carlos Lamas, Steven Swanson, David K. Clawson, Junliang Hao, Carlos Montero, Teresa Man, Shane Atwell, Barry Peter Clark, Jing Wang
Publikováno v:
Journal of Medicinal Chemistry. 58:7526-7548
Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we detail the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d4b305d2ec1acea2f3d473c73251c1
https://doi.org/10.1021/acs.jmedchem.5b01124
https://doi.org/10.1021/acs.jmedchem.5b01124
Autor:
Junliang Hao, Matt R. Reinhard, Barry Peter Clark, Jaime Blanco, Concepción Pedregal, Shane Atwell, Michael P. Johnson, Paul Goldsmith, Carlos Montero, Rosa Maria A. Simmons, James A. Monn, Steven Swanson, Chuanxi Xiang, Bryan G. Johnson, Frances Lu, Lorena Taboada, Teresa Man, David K. Clawson, Marijane Russell, Lesley Walton, Steven S. Henry, Jing Wang, Beverly A. Heinz, S. Richard Baker, Helen E. Sanger, Xushan Wang, David B. Shaw, Lourdes Prieto, Mark G. Bures, Joan H. Carter, Lisa M. Broad, Kelly L. Knopp, Helene Rudyk, David L. McKinzie, David Edward Tupper, Christopher David Beadle, John T. Catlow, Carlos Lamas, Alicia Marcos
Publikováno v:
Journal of Medicinal Chemistry. 58:1776-1794
As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the identification of the C4α-methyl analog of mGlu2/3 receptor agonist 1 (LY354740). This molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527bce29ceb86979086e1027b9d87633
https://doi.org/10.1021/jm501612y
https://doi.org/10.1021/jm501612y
Autor:
Adrian J. Mogg, David B. Shaw, Patrick M. Sexton, Arthur Christopoulos, Christian C. Felder, Richard E Loiacono, David L. McKinzie, Katie Leach
Publikováno v:
Neuropsychopharmacology. 35:855-869
We recently identified LY2033298 as a novel allosteric potentiator of acetylcholine (ACh) at the M(4) muscarinic acetylcholine receptor (mAChR). This study characterized the molecular mode of action of this modulator in both recombinant and native sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418839cabcbed830f500968dc2274dc7
https://doi.org/10.1038/npp.2009.194
https://doi.org/10.1038/npp.2009.194
Autor:
James A, Monn, Lourdes, Prieto, Lorena, Taboada, Junliang, Hao, Matthew R, Reinhard, Steven S, Henry, Christopher D, Beadle, Lesley, Walton, Teresa, Man, Helene, Rudyk, Barry, Clark, David, Tupper, S Richard, Baker, Carlos, Lamas, Carlos, Montero, Alicia, Marcos, Jaime, Blanco, Mark, Bures, David K, Clawson, Shane, Atwell, Frances, Lu, Jing, Wang, Marijane, Russell, Beverly A, Heinz, Xushan, Wang, Joan H, Carter, Brian G, Getman, John T, Catlow, Steven, Swanson, Bryan G, Johnson, David B, Shaw, David L, McKinzie
Publikováno v:
Journal of medicinal chemistry. 58(18)
Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we detail the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3e08f0001b2fb8da6ecccee3a121fe3
https://pubmed.ncbi.nlm.nih.gov/26313429
https://pubmed.ncbi.nlm.nih.gov/26313429