Zobrazeno 1 - 10
of 36
pro vyhledávání: '"David B. Rubin"'
Autor:
Kenneth R. Chapman, Steven W. Yancey, David B Rubin, Stephanie Harris, Ian D. Pavord, Eric S. Bradford, Frank C. Sciurba, Bhabita Mayer, Pierluigi Paggiaro, Mona Bafadhel
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease
Background A pre-specified meta-analysis of individual patient data from the 52-week METREX and METREO trials, which investigated mepolizumab for chronic obstructive pulmonary disease (COPD) in patients with blood eosinophil counts ≥150 cells/µL (
Autor:
Bruce E. Miller, Benjamin D. Horne, Courtney Crim, Dawn Midwinter, Rehan Ali, David B Rubin, Catherine Scott-Wilson
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease
Benjamin D Horne,1,2 Rehan Ali,3 Dawn Midwinter,3 Catherine Scott-Wilson,4 Courtney Crim,4 Bruce E Miller,5 David B Rubin4 1Intermountain Medical Center Heart Institute, Salt Lake City, UT, USA; 2Division of Cardiovascular Medicine, Department of Med
The Ethical Educator: Pointers & Pitfalls for School Administrators is an accessible, nuts-and-bolts resource for education leaders at the school and district levels as they confront difficult ethical situations in their day-to-day work. The book fea
Autor:
Jie Wang-Jairaj, Catherine Scott-Wilson, Mark T. Dransfield, David B Rubin, Dawn Midwinter, John R. Cockcroft, Courtney Crim, Surya P. Bhatt
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease
Surya P Bhatt,1 Mark T Dransfield,1 John R Cockcroft,2 Jie Wang-Jairaj,3 Dawn A Midwinter,3 David B Rubin,4 Catherine A Scott-Wilson,4 Courtney Crim4 1Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of
Autor:
Bhabita Mayer, Ian D. Pavord, Huib A. M. Kerstjens, Stephanie Harris, David B Rubin, Daniel J. Bratton, Gerard J. Criner, Oliver N. Keene, Steven W. Yancey, Eric S. Bradford
Publikováno v:
Clinical Problems.
Background: In METREX and METREO, mepolizumab reduced exacerbation rates in patients (pts) with eosinophilic COPD. In severe asthma, log-transformed screening blood eosinophil count (sBEC) is a strong predictor of mepolizumab efficacy; however, it is
Autor:
David B Rubin, Michael O'Neal, Dmitry V Galkin, Sally Lettis, Courtney Crim, Sophie Bennett, Harris A. Ahmad
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease
Background Patients with COPD are at risk for life-threatening pneumonia. Although anatomical abnormalities in the thorax may predispose to pneumonia, those abnormalities identified on routine chest X-rays (CXRs) in patients with COPD have not been s
Autor:
Jean-Louis Pépin, David B Rubin, Stefan Andreas, Dawn Midwinter, John R. Cockcroft, Sanjay Sharma
Publikováno v:
Chest. 146:1521-1530
BACKGROUND: Increased arterial stiffness as measured by aortic pulse wave velocity (aPWV) predicts cardiovascular events and mortality and is elevated in patients with COPD. Prior investigation suggests that a long-acting β-agonist (LABA)/inhaled co
Autor:
Bhabita Mayer, Frank C. Sciurba, Frank C. Albers, Pascal Chanez, David B Rubin, Stephanie Harris, Jean-Benoit Martinot, Steven W. Yancey, Njira L Lugogo, Eric S. Bradford
Publikováno v:
Clinical Problems.
Autor:
Stephanie Harris, David B Rubin, Hironori Sagara, Huib A. M. Kerstjens, Steven W. Yancey, Gerard J. Criner, Eric S. Bradford, Stephanie Korn, Bhabita Mayer, Ian D. Pavord, Frank C. Albers
Publikováno v:
Clinical Problems.
Background: Patients with eosinophilic COPD & frequent exacerbations may benefit from mepolizumab (MEP) treatment. Objective: Assess efficacy & safety of 2 MEP doses vs placebo (PBO) in COPD with blood eosinophils ≥150 cells/µL [screening] or ≥3
Publikováno v:
British Journal of Clinical Pharmacology. 75:1478-1487
Aim To investigate the effects of the cytochrome P450 3A4 (CYP3A4) inhibitor ketoconazole on the pharmacokinetics (PK) and pharmacodynamics of fluticasone furoate (FF) and vilanterol trifenatate (VI). Methods Two double-blind, randomized, placebo-con