Zobrazeno 1 - 10
of 33
pro vyhledávání: '"David B. Murray"'
Publikováno v:
Diabetes
This article outlines evidence that advanced glycation end product (AGE) inhibitors and breakers act primarily as chelators, inhibiting metal-catalyzed oxidation reactions that catalyze AGE formation. We then present evidence that chelation is the mo
Autor:
David B. Murray, Pamela Harding
Publikováno v:
Life Sciences. 89:671-676
Although the role of Cox-2 in the heart's response to physiologic stress remains controversial (i.e. expression in myocytes versus other resident myocardial cells) the ever expanding role of prostanoids in multiple models of heart failure cannot be d
Publikováno v:
Hypertension. 55:270-276
Chronic activation of the sympathetic nervous system is a key component of cardiac hypertrophy and fibrosis. However, previous studies have provided evidence that also implicate inflammatory cells, including mast cells (MCs), in the development of ca
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 297:H109-H116
The objective of this study was to investigate the ability of selective endothelin receptor subtype A (ETA) endothelin receptor antagonism (ETA) to prevent the acute myocardial remodeling process secondary to volume overload. Left ventricular tissue
Autor:
Rebecca M. Freeman, Gregory L. Brower, David B. Murray, Scott P. Levick, Wayne Carver, Jennifer L. McLarty
Publikováno v:
Hypertension. 53:1041-1047
Correlative data suggest that cardiac mast cells are a component of the inflammatory response that is important to hypertension-induced adverse myocardial remodeling. However, a causal relationship has not been established. We hypothesized that adver
Autor:
David B. Murray, John W. Baynes
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2, Iss 5, Pp 328-334 (2009)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
This study investigated the temporal relationship between cardiomyopathy and renal pathology in the type II diabetic Zucker diabetic fatty (ZDF) rat. We hypothesized that changes in renal function will precede the development of cardiac dysfunction i
Autor:
Joseph S. Janicki, Juming Zhong, David B. Murray, Yan-Feng Ding, Merrilee Holland, Gregory L. Brower, Qiao Zhong
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 35:827-835
1. Previous studies have demonstrated progressive ventricular hypertrophy, dilatation and contractile depression in response to chronic volume overload. Whether this decompensation was related to intrinsic myocyte dysfunction was not clear. The prese
Autor:
Mary F. Forman, L. G. Morgan, David B. Murray, Tetyana G. Voloshenyuk, Gregory L. Brower, Scott P. Levick, Joseph S. Janicki
Publikováno v:
Inflammation Research. 57:241-246
The purpose of this study was to determine the feasibility of adapting peritoneal and pleural mast cell isolation techniques to recover cardiac mast cells that retain their functional response to the secretagogue, compound 48/80.Using a novel protoco
Autor:
Jason D. Gardner, Gregory L. Brower, David B. Murray, Joseph S. Janicki, Scott P. Levick, Loren G Morgan
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H1216-H1222
Previously, our laboratory demonstrated that cardiac mast cell degranulation induces adverse ventricular remodeling in response to chronic volume overload. The purpose of this study was to investigate whether atrial natriuretic peptide (ANP), which i
Autor:
David B. Murray, Tetyana G. Voloshenyuk, Mary F. Forman, Gregory L. Brower, Scott P. Levick, Jason D. Gardner, Joseph S. Janicki
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 30:604-610
Elevations in myocardial stress initiate structural remodeling of the heart in an attempt to normalize the imposed stress. This remodeling consists of cardiomyocyte hypertrophy and changes in the amount of collagen, collagen phenotype and collagen cr