Zobrazeno 1 - 10
of 72
pro vyhledávání: '"David B. Ludlum"'
Publikováno v:
Carcinogenesis. 22:661-664
DNA damage is thought to be the initial event that causes sulfur mustard (SM) toxicity, while the ability of cells to repair this damage is thought to provide a degree of natural protection. To investigate the repair process, we have damaged plasmids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97227fb20c97dffa35c7f2f0e1ba41c
https://doi.org/10.1093/carcin/22.4.661
https://doi.org/10.1093/carcin/22.4.661
Publikováno v:
Chemico-Biological Interactions. 100:77-84
Since the toxicities of sulfur mustard are attributed to DNA alkylation, levels of DNA modification in exposed cells should correlate with the intensity of exposure. We have found that 32 P-postlabeling can be used successfully to detect the major ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f96867c0a39da7575f669f597e0393
https://doi.org/10.1016/s0009-2797(96)03690-3
https://doi.org/10.1016/s0009-2797(96)03690-3
Publikováno v:
Carcinogenesis. 17:2249-2252
The toxic effects of sulfur mustard have been attributed to DNA modification with the formation of 7-hydroxyethylthioethyl guanine, 3-hydroxyethylthioethyl adenine and the cross-link, di-(2-guanin-7-yl-ethyl)sulfide. To investigate the action of bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4a24423a0edf79fd60c51a14bb41e9
https://doi.org/10.1093/carcin/17.10.2249
https://doi.org/10.1093/carcin/17.10.2249
Publikováno v:
Proceedings of the National Academy of Sciences. 91:7232-7236
Many antitumor agents, including the mustards, form N-7 deoxyguanosine adducts in DNA that are difficult to quantitate by the 32P-postlabeling procedure because of their instability. We have developed a method that is successful for the analysis of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c848ead84bb58fb91a78a8385bf65325
https://doi.org/10.1073/pnas.91.15.7232
https://doi.org/10.1073/pnas.91.15.7232
Publikováno v:
Chemico-Biological Interactions. 91:39-49
Sulfur mustard is acutely toxic to the skin, eyes, and respiratory tract, and is considered carcinogenic to humans by the IARC. Since all of these toxicities are thought to be initiated by DNA alkylation, the level of DNA damage should serve as a bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5922f92d5c7ce5967861b32095e7e1
https://doi.org/10.1016/0009-2797(94)90005-1
https://doi.org/10.1016/0009-2797(94)90005-1
Publikováno v:
Proceedings of the National Academy of Sciences. 89:9331-9334
The human carcinogen vinyl chloride is metabolized in the liver to reactive intermediates which form N2,3-ethenoguanine in DNA. N2,3-Ethenoguanine is known to cause G----A transitions during DNA replication in Escherichia coli, and its formation may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c303638b1f5120dc522bcc6ae5737e85
https://doi.org/10.1073/pnas.89.19.9331
https://doi.org/10.1073/pnas.89.19.9331
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 29:223-230
A small-scale synthesis of high specific activity, N-(2-chloro2-[3H]-ethyl)-N′ -cyclohexyl-N-nitrosourea ([3H]-CCNU) has been accomplished from tritium-labelled ethanolamine. The product is pure by TLC and HPLC analysis and has been used successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf866d1da66ffa2f9431d4b08b8255f
https://doi.org/10.1002/jlcr.2580290212
https://doi.org/10.1002/jlcr.2580290212
Publikováno v:
Biochemical Pharmacology. 39:33-36
The 2-haloethylnitrosoureas have been shown to form the cross-linked structure 1-(3-cytosinyl),2-(1-guanyl)ethane in DNA. This cross-link has now been synthesized by the reaction of O6-(2-fluoroethyl)guanosine with deoxycytidine in dimethyl sulfoxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e27747952bca92696f939545621d77fd
https://doi.org/10.1016/0006-2952(90)90645-2
https://doi.org/10.1016/0006-2952(90)90645-2
Autor:
David B. Ludlum
Publikováno v:
Cancer Therapeutics ISBN: 9781617370465
Several of the most important principles in cancer drug development are illustrated by the discovery of the nitrosoureas as antitumor agents: the success of random screening in finding new agents; the importance of the assay system in evaluating new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf76e42f262cb38bd113226eb15a0d91
https://doi.org/10.1385/0-89603-460-7:81
https://doi.org/10.1385/0-89603-460-7:81
Autor:
Michael R. Volkert, Qiong Li, David B. Ludlum, Wincha Chong, Stephen E. Wright, Zdenka Matijasevic
Publikováno v:
Carcinogenesis. 24(3)
To investigate the possible role of glycosylase action in causing tumor resistance, a full-length, histidine-tagged human alkyladenine glycosylase has been purified from the cloned human gene contained in a pTrc99A vector propagated in a tag alkA mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3cae43c74da216809e684be394bb9e
https://pubmed.ncbi.nlm.nih.gov/12663522
https://pubmed.ncbi.nlm.nih.gov/12663522