Zobrazeno 1 - 10
of 79
pro vyhledávání: '"David B. Lovejoy"'
Autor:
Marcela Cespedes, Kelly R. Jacobs, Paul Maruff, Alan Rembach, Christopher J. Fowler, Brett Trounson, Kelly K. Pertile, Rebecca L. Rumble, Stephanie R. Rainey-Smithe, Christopher C. Rowe, Victor L. Villemagne, Pierrick Bourgeat, Chai K. Lim, Pratishtha Chatterjee, Ralph N. Martins, Arne Ittner, Colin L. Masters, James D. Doecke, Gilles J. Guillemin, David B. Lovejoy
Publikováno v:
Neurobiology of Disease, Vol 171, Iss , Pp 105783- (2022)
Increasing evidence suggests that kynurenine pathway (KP) dyshomeostasis may promote disease progression in dementia. Studies in Alzheimer's disease (AD) patients confirm KP dyshomeostasis in plasma and cerebrospinal fluid (CSF) which correlates with
Externí odkaz:
https://doaj.org/article/75df2cb1e7904b2c830ffb9d9588ebf8
Autor:
Yanjie Liu, Wendie Wang, Dongya Zhang, Yajing Sun, Fangzhou Li, Meng Zheng, David B. Lovejoy, Yan Zou, Bingyang Shi
Publikováno v:
Exploration, Vol 2, Iss 4, Pp n/a-n/a (2022)
Abstract Glioblastoma (GBM) is a central nervous system tumor with poor prognosis due to the rapid development of resistance to mono chemotherapy and poor brain targeted delivery. Chemoimmunotherapy (CIT) combines chemotherapy drugs with activators o
Externí odkaz:
https://doaj.org/article/76e6c52a9518490fb0d23b2c73e63106
Autor:
Benjamin Heng, Ayse A. Bilgin, David B. Lovejoy, Vanessa X. Tan, Heloisa H. Milioli, Laurence Gluch, Sonia Bustamante, Tharani Sabaretnam, Pablo Moscato, Chai K. Lim, Gilles J. Guillemin
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020)
Abstract Background Immunotherapy has recently been proposed as a promising treatment to stop breast cancer (BrCa) progression and metastasis. However, there has been limited success in the treatment of BrCa with immune checkpoint inhibitors. This im
Externí odkaz:
https://doaj.org/article/2339ab5edf5e4945b152f4b86d3c26f6
Autor:
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independe
Externí odkaz:
https://doaj.org/article/e876417f779b424199b53d555843b257
Autor:
Maju Mathew Koola, Michael Y. Bai, Gilles J. Guillemin, David B. Lovejoy, Rouba Kozak, Trevor W. Stone
Publikováno v:
Complex Psychiatry
The kynurenine pathway (KP) is a major route for L-tryptophan (L-TRP) metabolism, yielding a variety of bioactive compounds including kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), quinolinic acid (QUIN), and picolinic acid (PIC). These tryptopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48572dfb513f0059b2bda7f71d4621b6
https://doi.org/10.1159/000515066
https://doi.org/10.1159/000515066
Autor:
Yan Zou, Yibin Wang, Sen Xu, Yanjie Liu, Jinlong Yin, David B. Lovejoy, Meng Zheng, Xing‐Jie Liang, Jong Bae Park, Yuri M. Efremov, Ilya Ulasov, Bingyang Shi
Publikováno v:
Advanced materials (Deerfield Beach, Fla.). 34(33)
Glioblastoma (GBM) is an intractable malignancy with high recurrence and mortality. Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows promising potential for GBM therapy in clinical trials. However, significant challenges i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460cead5a9fd090b43d573f67d0cc643
https://pubmed.ncbi.nlm.nih.gov/35738390
https://pubmed.ncbi.nlm.nih.gov/35738390
Autor:
Maryam Mohammadi, Ralph N. Martins, Preeti Dave, Prita R. Asih, David B. Lovejoy, Steve Pedrini, Henrik Zetterberg, Kevin Taddei, Kaikai Shen, Hamid R. Sohrabi, Nicholas J. Ashton, Pratishtha Chatterjee, Cintia B. Dias, Tejal M. Shah, Kathryn Goozee, Kaj Blennow, Abdul Hye
Publikováno v:
Journal of Alzheimer's Disease
Background/Objective: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation. Given that iron dyshomeostasis has been observed in Alzheim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09aff23e97c7a770ea6ba81f057fb673
https://doi.org/10.3233/jad-200162
https://doi.org/10.3233/jad-200162
Autor:
Muhammad Ismail, Wen Yang, Yanfei Li, Yibin Wang, Wenya He, Jiefei Wang, Pir Muhammad, Timothy B. Chaston, Fawad Ur Rehman, Meng Zheng, David B. Lovejoy, Bingyang Shi
Publikováno v:
Biomaterials. 289:121760
Selective targeting of elevated copper (Cu) in cancer cells by chelators to induce tumor-toxic reactive oxygen species (ROS) may be a promising approach in the treatment of glioblastoma multiforme (GBM). Previously, the Cu chelator di-2-pyridylketone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2615140f8aad172dce372e25743ca79
https://doi.org/10.1016/j.biomaterials.2022.121760
https://doi.org/10.1016/j.biomaterials.2022.121760