Výsledky vyhledávání - "David B. Liesenfeld"

Akademický článek

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

Autor: Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer, Odilia Popanda

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after

Externí odkaz: https://doaj.org/article/8d2cbcdc585d437387a5d8eedf91802c

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Akademický článek

Multiplatform Urinary Metabolomics Profiling to Discriminate Cachectic from Non-Cachectic Colorectal Cancer Patients: Pilot Results from the ColoCare Study

Publikováno v: Metabolites, Vol 9, Iss 9, p 178 (2019)

Cachexia is a multifactorial syndrome that is characterized by loss of skeletal muscle mass in cancer patients. The biological pathways involved remain poorly characterized. Here, we compare urinary metabolic profiles in newly diagnosed colorectal ca

Externí odkaz: https://doaj.org/article/49bea54fb5644d7bbbeb3e8607750fa6

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Supplementary Material from Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial

Autor: Cornelia M. Ulrich, Johanna W. Lampe, John D. Potter, Karel D. Klika, Odilia Popanda, Christoph Weigel, Reka Toth, Nina Habermann, Akke Botma, David B. Liesenfeld

Supplementary Materials and Methods. Supplementary Figure 1: Study design of the ABC intervention study. Supplementary Figure 2: Intracellular concentrations of free salicylate in aspirin treated colorectal cancer cell lines expressed as nmol per tot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00eb4f1cf3044dfe3e96a96a8e400dfc
https://doi.org/10.1158/1055-9965.22437900

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Supplementary Methods, Supplementary Table, and Supplementary Figure from Review of Mass Spectrometry–Based Metabolomics in Cancer Research

Autor: Cornelia M. Ulrich, Augustin Scalbert, Robert W. Owen, Nina Habermann, David B. Liesenfeld

PDF - 217KB, Additional information regarding the search strategy used in the main paper. Supplementary Table: List of reported metabolites to be altered in human cancers. Supplementary Figure: General overview over the metabolomics workflow.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756c1e67aacc374c8357f0ff68c24fc9
https://doi.org/10.1158/1055-9965.22437652

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Data from Review of Mass Spectrometry–Based Metabolomics in Cancer Research

Autor: Cornelia M. Ulrich, Augustin Scalbert, Robert W. Owen, Nina Habermann, David B. Liesenfeld

Metabolomics, the systematic investigation of all metabolites present within a biologic system, is used in biomarker development for many human diseases, including cancer. In this review, we investigate the current role of mass spectrometry–based m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d931016be1db270f8f06c0e94a3568
https://doi.org/10.1158/1055-9965.c.6515992.v1

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Data from Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial

Autor: Cornelia M. Ulrich, Johanna W. Lampe, John D. Potter, Karel D. Klika, Odilia Popanda, Christoph Weigel, Reka Toth, Nina Habermann, Akke Botma, David B. Liesenfeld

Background: Aspirin use is an effective strategy for the chemoprevention of colorectal cancer, even at low doses. However, in order to implement aspirin interventions, risk–benefit balances and biologic mechanisms need to be better defined; to furt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f82dd5d92fa09860002766d09f8490f
https://doi.org/10.1158/1055-9965.c.6516111.v1

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TET-mediated hydroxymethylcytosine at the Pparγ locus is required for initiation of adipogenic differentiation

Autor: D. G. Seo, David B. Liesenfeld, Christoph Plass, Christoph Weigel, Anders Lindroth, Yoon Jung Park, Joo Hyun Park, Dieter Weichenhan, Yeongran Yoo

Publikováno v: International Journal of Obesity. 41:652-659

Adipose tissue is one of the main organs regulating energy homeostasis via energy storage as well as endocrine function. The adipocyte cell number is largely determined by adipogenesis. While the molecular mechanism of adipogenesis has been extensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cb1c8533912a9c9641b0c5299cc12f
https://doi.org/10.1038/ijo.2017.8

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Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

Autor: Jenny Chang-Claude, Christopher C. Oakes, Yassen Assenov, Marlon R. Veldwijk, David B. Liesenfeld, Christoph Rösli, Alla Slynko, Roger Sandhoff, Sabrina Hanke, Christoph Weigel, Petra Seibold, Mariona Rabionet, Elena Sperk, Axel Benner, Peter Schmezer, Odilia Popanda, Carsten Herskind, Frederik Wenz, Christoph Plass

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications

Radiotherapy is a fundamental part of cancer treatment but its use is limited by the onset of late adverse effects in the normal tissue, especially radiation-induced fibrosis. Since the molecular causes for fibrosis are largely unknown, we analyse if

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0c57aa34b04827e0b7f534875df946
https://doaj.org/article/8d2cbcdc585d437387a5d8eedf91802c

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