Zobrazeno 1 - 10
of 72
pro vyhledávání: '"David B. Langley"'
Autor:
Romain Rouet, Jake Y. Henry, Matt D. Johansen, Meghna Sobti, Harikrishnan Balachandran, David B. Langley, Gregory J. Walker, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Ohan Mazigi, Peter Schofield, Deborah L. Burnett, Simon H. J. Brown, Marianne Martinello, Bernard Hudson, Nicole Gilroy, Jeffrey J. Post, Anthony Kelleher, Hans-Martin Jäck, Christopher C. Goodnow, Stuart G. Turville, William D. Rawlinson, Rowena A. Bull, Alastair G. Stewart, Philip M. Hansbro, Daniel Christ
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here, Rouet et al. present a strategy for the identification of broadly neutralising antibodies against SARS-CoV-2 receptor binding domain from peripheral blood mononuclear cells of convalescent patients, which enabled the identification of a new cla
Externí odkaz:
https://doaj.org/article/d7c35bcc59bc4a9fb845343c96f9aa30
Autor:
Romain Rouet, Ohan Mazigi, Gregory J. Walker, David B. Langley, Meghna Sobti, Peter Schofield, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Jake Y. Henry, Arunasingam Abayasingam, Deborah Burnett, Anthony Kelleher, Robert Brink, Rowena A. Bull, Stuart Turville, Alastair G. Stewart, Christopher C. Goodnow, William D. Rawlinson, Daniel Christ
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear. This is exemplified by a set of iconic and well-characterized monoclonal ant
Externí odkaz:
https://doaj.org/article/cad1878f11e24fe7a3dee032090722d6
Autor:
Claudia Loetsch, Joanna Warren, Adrienne Laskowski, Rodrigo Vazquez-Lombardi, Christoph Jandl, David B. Langley, Daniel Christ, David R. Thorburn, David K. Ryugo, Jonathan Sprent, Marcel Batten, Cecile King
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1624-1638 (2017)
Summary: The archetypal T cell-dependent antigen is sheep red blood cells (SRBCs), which have defined much of what we know about humoral immunity. Early studies using solubilized or sonicated SRBCs argued that the intact structure of SRBCs was import
Externí odkaz:
https://doaj.org/article/9b78d4ab3122444eaffd0facbe60a14a
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
In vitro selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high affinity binders can be selected from diverse repertoires. Here, we review strategies f
Externí odkaz:
https://doaj.org/article/dcd8899530fb42a08cae1356dadae681
Autor:
David B. Langley, Peter Schofield, Damien Nevoltris, Jennifer Jackson, Katherine J. L. Jackson, Tim J. Peters, Melanie Burk, Jacqueline M. Matthews, Antony Basten, Christopher C. Goodnow, Sheryl van Nunen, Joanne H. Reed, Daniel Christ
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Humans lack the capacity to produce the Galα1–3Galβ1–4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut bacteria, malaria parasites, cetuximab, a
Autor:
Peter R. Schofield, Man-Tat Lau, Jean Yang, David B. Langley, Thang M. Khuong, Danielle Nessem, Marina Pajic, Daniel Christ, Angela Chou, Jourdin R. Rouaen, Jamie B. Littleboy, Damien Nevoltris, Shila Ghazanfar, G. Gregory Neely, Ashleigh Parkin
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Genome Biology
Genome Biology
Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. Results In addition to
Autor:
Hans-Martin Jäck, Bernadette M. Saunders, Harikrishnan Balachandran, Peter R. Schofield, William D. Rawlinson, Hui Li, Matthew A. Spence, Rowena A. Bull, Nicole G. Hansbro, Katherine J. L. Jackson, Jake Y. Henry, Robert Brink, Philip M. Hansbro, Anupria Aggrawal, Simon Schäfer, Deborah L. Burnett, Christopher C. Goodnow, Rudolfo Karl, David B. Langley, Daniel Christ, Alastair G. Stewart, Warwick J. Britton, Colin J. Jackson, Gregory J. Walker, Jennifer Jackson, Edith Roth, Thomas Winkler, Mandeep Singh, Helen Lenthall, Sean Emery, Claire Milthorpe, Alberto Ospina Stella, Franka Witthauer, Anthony D. Kelleher, Marianne Martinello, Matt D. Johansen, Romain Rouet, Stuart Turville, Sebastian R. Schulz
Publikováno v:
Immunity
Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second generation vaccines will need to elicit neutralizing antibodies against sites that are evolutionarily conserved across the sarbecovirus subgenus. Here, we imm
Publikováno v:
Neuropeptides. 92
Neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) form the evolutionarily conserved pancreatic polypeptide family. While the fold is widely utilized in nature, crystal structures remain elusive, particularly for the human forms,
Autor:
Robert Brink, David Zahra, Jeanette E. Villanueva, Benjamin T. Porebski, Garry P. Nolan, Murray P. Cox, Carla M. Roots, Claudia Loetsch, Cecile King, Paul Z. Benitez-Aguirre, Jia Tang, Belinda Whittle, Juliana Teo, Joanna Warren, Wendy Sandoval, Marcel E. Dinger, Elisabeth K. Malle, Christopher C. Goodnow, Geeta Chaudhri, Velimir Gayevskiy, Ingrid E. Wertz, Jin Yan Yap, John B. Ziegler, Yogesh Jeelall, Keisuke Horikawa, Colin J. Jackson, Stacey N. Walters, Daniele Cultrone, Daniel Christ, Frank Schmitz, Nathan W. Zammit, Shane T. Grey, Melanie Wong, David B. Langley, Craig N. Jenne, Owen M. Siggs, Tim Wiltshire, Anselm Enders, Lewis L. Lanier, Mark J. Cowley, Matthew H. Spitzer, Wilson Phung, Stuart G. Tangye, Peter D. Mabbitt, Derek W. Abbott, Susan R. Watson, Benjamin E. Clifton, Stephen R. Daley, Alan Aderem, Paul Gray, Ashley M. Buckle, Gunasegaran Karupiah, Michiko Yamada, Edward M. Bertram, Amanda J. Russell, Maria E. Craig
Publikováno v:
Nature Immunology. 20:1299-1310
Resisting and tolerating microbes are alternative strategies to survive infection, but little is known about the evolutionary mechanisms controlling this balance. Here genomic analyses of anatomically modern humans, extinct Denisovan hominins and mic