Zobrazeno 1 - 10
of 106
pro vyhledávání: '"David B. Hill"'
Autor:
Kathleen L. Furtado, Lucas Plott, Matthew Markovetz, Deborah Powers, Hao Wang, David B. Hill, Jason Papin, Nancy L. Allbritton, Rita Tamayo
Publikováno v:
mSphere, Vol 9, Iss 6 (2024)
ABSTRACT In a healthy colon, the stratified mucus layer serves as a crucial innate immune barrier to protect the epithelium from microbes. Mucins are complex glycoproteins that serve as a nutrient source for resident microflora and can be exploited b
Externí odkaz:
https://doaj.org/article/450e725c3eaa4445b01f73bf39855948
Autor:
Matthew A. Greenwald, Suzanne L. Meinig, Lucas M. Plott, Cristian Roca, Matthew G. Higgs, Nicholas P. Vitko, Matthew R. Markovetz, Kaitlyn R. Rouillard, Jerome Carpenter, Mehmet Kesimer, David B. Hill, Jonathan C. Schisler, Matthew C. Wolfgang
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT The airway milieu of individuals with muco-obstructive airway diseases (MADs) is defined by the accumulation of dehydrated mucus due to hyperabsorption of airway surface liquid and defective mucociliary clearance. Pathological mucus becomes
Externí odkaz:
https://doaj.org/article/2350a3a545274361935d27d4e0206ed0
Autor:
Kaitlyn R. Rouillard, Christopher P. Esther, William J. Kissner, Lucas M. Plott, Dean W. Bowman, Matthew R. Markovetz, David B. Hill
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/5c65134c82964ce98370313c40b1e9ce
Autor:
Kaitlyn R. Rouillard, Matthew R. Markovetz, William J. Kissner, William L. Boone, Lucas M. Plott, David B. Hill
Publikováno v:
Biofilm, Vol 5, Iss , Pp 100104- (2023)
The viscoelastic properties of biofilms are correlated with their susceptibility to mechanical and chemical stress, and the airway environment in muco-obstructive pulmonary diseases (MOPD) facilitates robust biofilm formation. Hyperconcentrated, visc
Externí odkaz:
https://doaj.org/article/c753f2302b8144688c2a073fe72f466c
Autor:
David B. Hill
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/479ec692d82e4baab05cd14496c078eb
Autor:
Matthew R. Markovetz, Jacob E. Hibbard, Lucas M. Plott, Lawrence G. Bacudio, William J. Kissner, Andrew Ghio, Priya A. Kumar, Harendra Arora, David B. Hill
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Across the globe, millions of people are affected by muco-obstructive pulmonary diseases like cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In MOPDs, the airway mucus becomes hyperconcentrated, increasing viscoelasticity and imp
Externí odkaz:
https://doaj.org/article/1f0605540aca4c1b8f60f009b529f4bb
Publikováno v:
mSphere, Vol 7, Iss 4 (2022)
ABSTRACT The pathological properties of airway mucus in cystic fibrosis (CF) are dictated by mucus concentration and composition, with mucins and DNA being responsible for mucus viscoelastic properties. As CF pulmonary disease progresses, the concent
Externí odkaz:
https://doaj.org/article/c90a0a37058d42b885c7d2990e83176b
Autor:
Laura A. Hancock, Corinne E. Hennessy, George M. Solomon, Evgenia Dobrinskikh, Alani Estrella, Naoko Hara, David B. Hill, William J. Kissner, Matthew R. Markovetz, Diane E. Grove Villalon, Matthew E. Voss, Guillermo J. Tearney, Kate S. Carroll, Yunlong Shi, Marvin I. Schwarz, William R. Thelin, Steven M. Rowe, Ivana V. Yang, Christopher M. Evans, David A. Schwartz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The promoter variant rs35705950 confers a gain of function to the MUC5B gene and is the dominant risk factor for idiopathic pulmonary fibrosis. Here the authors show that mice overexpressing Muc5b in distal airspaces show impaired mucociliary clearan
Externí odkaz:
https://doaj.org/article/179e7c61d4b74fa68c0ec80470732ff6
Publikováno v:
Physiological reviews. 102(4)
The mucus clearance system is the dominant mechanical host defense system of the human lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid pumping and cough-dependent mechanisms, and mucus transport rates ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f9f76d4e66312e1292243a95ca5b57
https://pubmed.ncbi.nlm.nih.gov/35001665
https://pubmed.ncbi.nlm.nih.gov/35001665
Autor:
Matthew R. Markovetz, Ian C. Garbarine, Cameron B. Morrison, William J. Kissner, Ian Seim, M. Gregory Forest, Micah J. Papanikolas, Ronit Freeman, Agathe Ceppe, Andrew Ghio, Neil E. Alexis, Stephen M. Stick, Camille Ehre, Richard C. Boucher, Charles R. Esther, Marianne S. Muhlebach, David B. Hill
Publikováno v:
Journal of Cystic Fibrosis. 21:959-966
Mucus hyperconcentration in cystic fibrosis (CF) lung disease is marked by increases in both mucin and DNA concentration. Additionally, it has been shown that half of the mucins present in bronchial alveolar lavage fluid (BALF) from preschool-aged CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d562eb564d7ab44b49b3eecdcbe0ec29
https://doi.org/10.1016/j.jcf.2022.04.008
https://doi.org/10.1016/j.jcf.2022.04.008