Zobrazeno 1 - 10
of 17
pro vyhledávání: '"David B. Gilberto"'
Autor:
Larry Handt, Richard Raubertas, David B. Gilberto, Liza Gantert, Jeremy Beech, Stacey Conarello, Tasha Gray, Steven Fox, Walter Knapp, Wendy J. Watson, Cai Li, Ashleigh Bone, Scott Tiesma, Patricia A. Rebbeck
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Until recently, preclinical and clinical work on diabetes has focused on the understanding of blood glucose elevation and its detrimental metabolic sequelae. The advent of continuous glucose monitoring (CGM) technology now allows real time monitoring
Autor:
Joseph J. DeGeorge, Hillary K. Regan, David B. Gilberto, Theodore J. Detwiler, Frederick Sannajust, Li Chen, Christopher P. Regan, Gary L. Stump
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 81:107-114
Introduction There has been an increasing need to conduct investigative safety pharmacology studies to complement regulatory-required studies, particularly as it applies to a comprehensive assessment of cardiovascular (CV) risk. Methods We describe r
Autor:
Donald B. Kimmel, David B. Gilberto, Nicholas T Gatto, Rana Samadfam, Brenda L Pennypacker, Le Thi Duong, Susan Y. Smith
Publikováno v:
Journal of Orthopaedic Research. 34:72-80
The effects of the cathepsin K inhibitor odanacatib (ODN) on fracture healing were monitored for ∼6 and 15 weeks post-fracture in two separate studies using the unilateral transverse mid-ulnar osteotomy model in skeletally mature female rabbits. Ra
Autor:
Guoxin Wu, Kristin R. Wildsmith, Andrew Stamford, Kevin E. Yarasheski, Matthew E. Kennedy, David B. Gilberto, Yuriy Pyatkivskyy, Randall J. Bateman, Daniel J. Holder, Mary J. Savage, Robert Chott, Debra A. McLoughlin, Justyna Dobrowolska, Bruce W. Patterson, Mandy Dancho, Tom Kasten, Vitaliy Ovod, Parker Mathers, Maria S. Michener, Christina Lennox, Brad E. Smith
Publikováno v:
Journal of Neuroscience. 34:8336-8346
BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering
Autor:
Eric A. Price, Gene G. Kinney, Randall J. Bateman, Maria S. Michener, Marie A. Holahan, Parker Mathers, Adam J. Simon, Kristin R. Wildsmith, Guoxin Wu, David B. Gilberto, Kevin E. Yarasheski, Mark S. Shearman, Jennifer X. Wang, Jacquelynn J. Cook
Publikováno v:
The Journal of Neuroscience. 30:6743-6750
The accumulation of amyloid β (Aβ) in Alzheimer's disease is caused by an imbalance of production and clearance, which leads to increased soluble Aβ species and extracellular plaque formation in the brain. Multiple Aβ-lowering therapies are curre
Autor:
Halea A. Corcoran, Nancy M. Dougherty, Elizabeth P. Baskin, David B. Gilberto, Xianzhi Mao, James C. Hershey, Jacquelynn J. Cook, Andrew J. Bett, Kenneth A. Thomas
Publikováno v:
Heart and Vessels. 18:142-149
This study was designed to test the ability of adenovirus-delivered vascular endothelial growth factor (Ad-VEGF) to stimulate angiogenesis and arteriogenesis in the rabbit hindlimb following the induction of ischemia and to evaluate the functional ch
Autor:
Joan D. Glass, Elizabeth P. Baskin, Halea A. Hartman, Jacquelynn J. Cook, James C. Hershey, Irene T. Rogers, David B. Gilberto
Publikováno v:
Cardiovascular Research. 49:618-625
Objective: Animal models of hindlimb ischemia are critical to our understanding of peripheral vascular disease and allow us to evaluate therapeutic strategies aimed to improve peripheral collateral circulation. To further elucidate the processes invo
Autor:
Harold G. Selnick, Nigel J. Liverton, David A. Claremon, Melanie S. Houle, David B. Gilberto, Andrew J. Tebben, Audrey A. Wallace, Smith Garry R, George E. Billman, Hossain Jahansouz, Gary L. Stump, Joseph J. Lynch
Publikováno v:
Circulation. 100:1917-1922
Background —To date, the lack of potent and selective inhibitors has hampered the physiological assessment of modulation of the cardiac slowly activating delayed rectifier current, I Ks . The present study, using the I Ks blocker L-768,673, represe
Autor:
Matthew E. Kennedy, Brad Smith, Guoxin Wu, Kevin E. Yarasheski, Christina Lennox, Randall J. Bateman, Justyna Dobrowolska, Dan Holder, Andrew Stamford, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Mandy Dancho, Tom Kasten, Maria S. Michener, Vitaliy Ovod, Parker Mathers, Debra A. McLoughlin, Bruce W. Patterson, David B. Gilberto, Robert Chott, Mary J. Savage
Publikováno v:
Alzheimer's & Dementia. 9
Autor:
Matthew E. Kennedy, David B. Gilberto, Zhong-Yue Sun, Guoxin Wu, Rachel Korn, Mandy Dancho, Jared N. Cumming, Christina Lennox, James C. Hershey, Izabela Suchecki, Debra A. McLoughlin, Andrew Stamford, Eric M. Parker, Mary J. Savage, Maria S. Michener, Zhaoning Zhu
Publikováno v:
Alzheimer's & Dementia. 8