Výsledky vyhledávání - "David B. Frank"

Akademický článek

Circadian regulation of lung repair and regeneration

Publikováno v: JCI Insight, Vol 8, Iss 16 (2023)

Optimal lung repair and regeneration are essential for recovery from viral infections, including influenza A virus (IAV). We have previously demonstrated that acute inflammation and mortality induced by IAV is under circadian control. However, it is

Externí odkaz: https://doaj.org/article/ac4e98bc89a84f5b8ce9124207a92a10

Zobrazit plný text záznamu

Akademický článek

In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease

Autor: Sourav K. Bose, Brandon M. White, Meghana V. Kashyap, Apeksha Dave, Felix R. De Bie, Haiying Li, Kshitiz Singh, Pallavi Menon, Tiankun Wang, Shiva Teerdhala, Vishal Swaminathan, Heather A. Hartman, Sowmya Jayachandran, Prashant Chandrasekaran, Kiran Musunuru, Rajan Jain, David B. Frank, Philip Zoltick, William H. Peranteau

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Lysosomal storage diseases like mucopolysaccharidosis type I (MPS I) cause pathology before birth and result in early morbidity and mortality. Here, the authors show that in utero base editing mediates multi-organ phenotypic and survival benefits in

Externí odkaz: https://doaj.org/article/a932a6ec2ba7497281b8dba976e50d99

Zobrazit plný text záznamu

Akademický článek

mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

The cellular origins of lymphangioleiomyomatosis (LAM), a rare fatal lung disease, are poorly understood. Here the authors identify a mesenchymal cell hub coordinating the LAM phenotype and develop a LAM mouse model where they investigate the co-oper

Externí odkaz: https://doaj.org/article/920f2bde4ce048d5a6bf73943fc2fe6e

Zobrazit plný text záznamu

Akademický článek

The in vivo genetic program of murine primordial lung epithelial progenitors

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

The identity of the earliest murine in vivo lung epithelial progenitors (marked by NKX2-1 expression) is unclear. Here, the authors use single-cell RNA sequencing to define the genetic program of these lung primordial progenitors, which will improve

Externí odkaz: https://doaj.org/article/3fb65185b9414530bfbace794788404c

Zobrazit plný text záznamu

Akademický článek

Variation in the use of pulmonary vasodilators in children and adolescents with pulmonary hypertension: a study using data from the MarketScan® insurance claims database

Autor: Michael L. O'Byrne, Jennifer A. Faerber, Hannah Katcoff, David B. Frank, Alex Davidson, Therese M. Giglia, Catherine M. Avitabile

Publikováno v: Pulmonary Circulation, Vol 10 (2020)

Despite progress in pharmacotherapy in pediatric pulmonary hypertension, real-world patterns of directed pulmonary hypertension therapy have not been studied in the current era. A retrospective observational study of children (≤18 years) with pulmo

Externí odkaz: https://doaj.org/article/7d5c8ab2084244d5af473936e3b0da82

Zobrazit plný text záznamu

Akademický článek

GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

Autor: Rafael Jesus Fernandez, Zachary JG Gardner, Katherine J Slovik, Derek C Liberti, Katrina N Estep, Wenli Yang, Qijun Chen, Garrett T Santini, Javier V Perez, Sarah Root, Ranvir Bhatia, John W Tobias, Apoorva Babu, Michael P Morley, David B Frank, Edward E Morrisey, Christopher J Lengner, F Brad Johnson

Publikováno v: eLife, Vol 11 (2022)

Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to

Externí odkaz: https://doaj.org/article/5a2e0adc44d4496d8818d07ddfebb226

Zobrazit plný text záznamu

Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features

Autor: Nya D. Nelson, Feng Xu, Prashant Chandrasekaran, Leslie A. Litzky, William H. Peranteau, David B. Frank, Marilyn Li, Jennifer Pogoriler

Publikováno v: Modern Pathology. 35:1870-1881

The potential pathogenetic mechanisms underlying the varied morphology of congenital pulmonary airway malformations (CPAMs) have not been molecularly determined, but a subset have been shown to contain clusters of mucinous cells (MCC). These clusters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2288dcaa9e648b6c8fc4b74647476228
https://doi.org/10.1038/s41379-022-01129-0

Zobrazit plný text záznamu

Endodermal BRD4 mediates epithelial-mesenchymal crosstalk during lung development

Autor: Derek C. Liberti, Hongbo Wen, Kwaku K. Quansah, Prashant Chandrasekaran, Josh Pankin, Nigel S. Michki, Annabelle Jin, MinQi Lu, Maureen Peers De Nieuwburgh, Lisa R. Young, Rajan Jain, David B. Frank

SUMMARYLung morphogenesis relies on diverse cell intrinsic and extrinsic mechanisms to ensure proper cellular differentiation and compartmentalization. Using genetic mouse models, tissue explants, and transcriptomic analysis, we demonstrate that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47fe0ce1e3a664b2f25074483dd0d2a4
https://doi.org/10.1101/2023.05.21.541621

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání