Zobrazeno 1 - 10
of 36
pro vyhledávání: '"David B. Fenske"'
Autor:
David B, Fenske, Pieter R, Cullis
Publikováno v:
Expert Opinion on Drug Delivery. 5:25-44
Liposomal nanoparticles (LNs) encapsulating therapeutic agents, or liposomal nanomedicines, represent an advanced class of drug delivery systems, with several formulations presently on the market and many more in clinical trials. Over the past 20 yea
Autor:
Angela M. Lam, David B. Fenske, Ammen P. Sandhu, Lorne R. Palmer, Pieter R. Cullis, Michael V. Johnston
Publikováno v:
Analytical Biochemistry. 341:156-164
Previous work from this laboratory has shown that plasmid DNA can be encapsulated in small (70-nm-diameter) stabilized plasmid–lipid particles (SPLP) that consist of a single plasmid encapsulated within a bilayer lipid vesicle. SPLP preferentially
Publikováno v:
Journal of Liposome Research. 14:155-173
Cationic poly(ethylene glycol)-lipid conjugates (CPLs), a class of lipid designed to enhance the interaction of liposomes with cells, possess the following architectural features: 1) a hydrophobic lipid anchor of distearoylphosphatidylethanolamine (D
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1512(2):259-272
This paper describes a new method for enhancing the interaction of liposomes with cells. A novel class of cationic poly(ethyleneglycol) (PEG)-lipid (CPL) conjugates have been characterized for their ability to insert into pre-formed vesicles and enha
Autor:
David B. Fenske, Marcel B. Bally, Pieter R. Cullis, Michael J. Hope, Thomas D. Madden, Lawrence D. Mayer
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes. 1331:187-211
Pieter R. Cullis , Michael J. Hope , Marcel B. Bally , Thomas D. Madden , Lawrence D. Mayer , David B. Fenske a a Department of Biochemistry and Molecular Biology, UniOersity of British Columbia, VancouOer, B.C., Canada V6T 1Z3 b Inex Pharmaceuticals
Publikováno v:
Biophysical Journal. 67:1562-1573
Deuterium NMR was used to characterize model membrane systems approximating the composition of the intercellular lipid lamellae of mammalian stratum corneum (SC). The SC models, equimolar mixtures of ceramide:cholesterol:palmitic acid (CER:CHOL:PA) a
Autor:
David B. Fenske
Publikováno v:
Chemistry and Physics of Lipids. 64:143-162
Correspondence to: David B. Fenske, Department of Biochemistry, Faculty of Medicine, University of British Columbia, 2146 Health Sciences Mall, Vancouver, B.C., Canada V6T 1Z3. Abbreviations: CHOL, cholesterol; CL, cardiolipin; D, lateral diffusion c
Autor:
Pieter R. Cullis, David B. Fenske
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1108:201-209
One- and two-dimensional 31P-exchange NMR has been used to investigate chemical exchange between coexisting lamellar (L alpha) and non-lamellar (hexagonal HII and cubic I2) lipid phases. Samples of DOPE, DOPE/DOPC (9:1 and 7:3), DOPE/cholesterol sulf
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1103:268-274
The role of glycosphingolipid fatty acid alpha-hydroxylation as a modulator of glycolipid organization and dynamics was considered by 2H-NMR in bilayer membranes. For these experiments, galactosylceramides were prepared in which the natural fatty aci