Zobrazeno 1 - 10 of 28 pro vyhledávání: '"David B. Danner"'
1
The proliferation theory of rejuvenation
Autor: David B. Danner
Publikováno v: Mechanisms of Ageing and Development. 65:85-107
A theory concerning the molecular basis of rejuvenation is presented that postulates a central role for cell proliferation. This theory assumes that aging is due to the accumulation of multiple forms of molecular damage and that rejuvenation is due t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c426a87f6cd8fc402147699f5096d84
https://doi.org/10.1016/0047-6374(92)90127-y
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3
Identification of estrogen receptor mRNA and the estrogen modulation of parathyroid hormone-stimulated cyclic AMP accumulation in opossum kidney cells
Autor: Elizabeth M. Burke, Jay R. Shapiro, David B. Danner, James A. Coderre, John L. Stock, Stewart D. Chipman
Publikováno v: Journal of Cellular Physiology. 150:517-525
The opossum kidney (OK) cell was used as a model to test the hypothesis that estrogen directly affects proximal renal tubular epithelial cells. To demonstrate the expression of estrogen receptor in OK cells, we developed an approach using reverse tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea12b5dedeb62101c9c7eb2338d268f
https://doi.org/10.1002/jcp.1041500312
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4
Changes in fibronectin mRNA splicing with in vitro passage
Autor: David B. Danner, Elizabeth M. Burke
Publikováno v: Biochemical and Biophysical Research Communications. 178:620-624
Senescent human fibroblasts produce larger fibronectin molecules with altered binding properties. To determine if this change could involve alternative splicing of fibronectin precursor mRNA, we developed an approach using reverse transcription and t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd235b8a70ba3a79c6cea2f5af26f99
https://doi.org/10.1016/0006-291x(91)90153-x
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5
Aberrant gene expression and aging: Examination of tissue-specific mRNAS in young and old rats
Autor: Edward L. Schneider, David B. Danner, Alice I. Sato
Publikováno v: Mechanisms of Ageing and Development. 54:1-12
It has been suggested that aberrant gene expression may play a role in aging. To test this possibility, we examined the steady-state mRNA levels for five tissue-specific genes of known function in young (6 month) and old (24 month) rats. Six differen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e48ff7ef78dfac5391d1b98eff08de7
https://doi.org/10.1016/0047-6374(90)90011-4
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6
DNA damage and rpair with age in individual human lymphocytes
Autor: Raymond R. Tice, Larry J. Brant, David B. Danner, Narendra P. Singh, Edward L. Schneider
Publikováno v: Mutation Research/DNAging. 237:123-130
Previous biochemical studies on DNA repair competence and aging have been limited to techniques, such as alkaline elution or nucleoid sedimentation, involving mass cell populations. These techniques provide no information about the distribution of DN
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0fb68474866e8e6c91678a6b47ae34
https://doi.org/10.1016/0921-8734(90)90018-m
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7
Assignment of the human prohibition gene (PHB) to chromosome 17 and identification of a DNA polymorphism
Autor: Mark J. Nuell, Garrison A. Owens, Varda Friedman, John J. White, Roger L. Eddy, Cynthia C. Morton, Carla M. Wood, David H. Ledbetter, David B. Danner, Thomas B. Shows, J.Keith McClung, David A. Stewart
Publikováno v: Genomics. 11:228-230
Prohibition is a recently identified antiproliferative protein whose exact role in the cell is under investigation. To determine the human chromosomal location of the prohibition gene (PHB) and whether this site corresponds to that of any suspected t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85971c32f71df664673b11805fbd2d2e
https://doi.org/10.1016/0888-7543(91)90126-y
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8
Regions of evolutionary conservation between the rat and human prohibitin-encoding genes
Autor: David B. Danner, David A. Stewart, Garrison Owens, Toni Henderson, A.Jane I. Roskams, Michael S. Altus, Mcclung J Keith, Varda Friedman, R T Dell'Orco, Eldon R. Jupe, Carla M. Wood
Publikováno v: Gene. 158(2)
We have analyzed and compared the 5′ promoter region, the intron structure and the exon-intron flanking sequences in the rat and human prohibitin-encoding genes (PHB) . Comparative analysis of a 350-nt region immediately 5′ to and including the f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7cae7579e8b33939b7e805d4b91f6a
https://pubmed.ncbi.nlm.nih.gov/7607556
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10
Cell cycle activity and expression of prohibitin mRNA
Autor: David A. Stewart, Garrison Owens, M. S. Altus, Carla M. Wood, Varda Friedman, David B. Danner, Xiao-Tie Liu, L. Walker, A. J. Roskams, J. K. Mcclung
Publikováno v: Journal of cellular physiology. 157(2)
Prohibitin, a novel intracellular antiproliferative protein, blocks entry into the S phase of the cell division cycle when its mRNA is microinjected into normal fibroblasts or HeLa cells. To learn more about the interaction between prohibitin and the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7779a003864a9021d40670b0639691f9
https://pubmed.ncbi.nlm.nih.gov/8227162
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