Zobrazeno 1 - 10
of 27
pro vyhledávání: '"David B. Cody"'
Autor:
David B. Cody, Xinmin S. Li, Xiaodong Gu, Jose C. Garcia-Garcia, Miranda K. Culley, Bruce S. Levison, David Bartlett, Joseph A. DiDonato, Stanley L. Hazen, Hong J. Dai, Yuping Wu, Jennifer Kirsop, Betzabe Rachel Lam-Galvez, Xiaoming Fu, Zeneng Wang, Matthew F. Copeland, W.H. Wilson Tang, Lin Li, Robert A. Koeth
Publikováno v:
Journal of Clinical Investigation. 129:373-387
BACKGROUND.l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway involving an atherogenic intermed
Autor:
Jennifer A. Buffa, Kymberleigh A. Romano, Matthew F. Copeland, David B. Cody, Weifei Zhu, Rachel Galvez, Xiaoming Fu, Kathryn Ward, Marc Ferrell, Hong J. Dai, Sarah Skye, Ping Hu, Lin Li, Mirjana Parlov, Amy McMillan, Xingtao Wei, Ina Nemet, Robert A. Koeth, Xinmin S. Li, Zeneng Wang, Naseer Sangwan, Adeline M. Hajjar, Mohammed Dwidar, Taylor L. Weeks, Nathalie Bergeron, Ronald M. Krauss, W. H. Wilson Tang, Federico E. Rey, Joseph A. DiDonato, Valentin Gogonea, G. Frank Gerberick, Jose Carlos Garcia-Garcia, Stanley L. Hazen
Publikováno v:
Nature microbiology, vol 7, iss 1
The heightened cardiovascular disease (CVD) risk observed among omnivores is thought to be linked, in part, to gut microbiota-dependent generation of trimethylamine-N-oxide (TMAO) from L-carnitine, a nutrient abundant in red meat. Gut microbial trans
Autor:
Xiaodong Gu, Stanley L. Hazen, Matthew W Russell, Jennifer A. Buffa, Jose C. Garcia-Garcia, Aldons J. Lusis, Nilaksh Gupta, Jodie Michelle Reed, Sarah M. Skye, Zeneng Wang, Alex G Hurd, Bruce S. Levison, David B. Cody, William T. Barrington, Joseph A. DiDonato, Lin Li, Adam B. Roberts, J. Mark Brown, Ashraf Duzan, Xiaoming Fu, Jennifer M. Lang, Alex J Myers, Weifei Zhu, Suguna Rachakonda, Valentin Gogonea
Publikováno v:
Nature Medicine. 24:1407-1417
Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite that enhances both platelet responsiveness and in vivo thrombosis potential in animal models, and TMAO plasma levels predict incident atherothrombotic event risks in human clinical
Autor:
Babak Dehghani, Chunhe Wang, I. Jack Magrisso, Laura A. Elenich, Arthur A. Vandenbark, Stephanie J. Murphy, Sandhya Subramanian, Edna Bonhomme, Halina Offner, Jan S. Rosenbaum, Martin J. Kelly, Elizabeth A. Rick, David B. Cody
Publikováno v:
Molecular Endocrinology. 22:636-648
The mechanisms by which prolonged estrogen exposures, such as estrogen therapy and pregnancy, reduce thymus weight, cellularity, and CD4 and CD8 phenotype expression, have not been well defined. In this study, the roles played by the membrane estroge
Publikováno v:
Muscle & Nerve. 32:775-781
Several GTP-binding protein (G-protein)-coupled receptors that signal through Galphas (GTP-binding protein alpha stimulatory) and the cyclic adenosine monophosphate (cAMP) pathway increase skeletal muscle mass. In order to further evaluate the role o
Publikováno v:
Endocrinology. 144:4939-4946
Two corticotropin-releasing factor 2 receptor (CRF2R)-selective peptides have been recently described, urocortin II (also known as stresscopin-related peptide) and urocortin III (stresscopin). We have used urocortin II to evaluate the effects of acti
Autor:
Jana S. Lange, Richard T. Hinkle, Elizabeth Donnelly, Eric Tobar, Russell James Sheldon, Sarah C. Coste, Steven Samuelsson, Robert J. Isfort, Mark A. Tarnopolsky, Mary Beth Bauer, David B. Cody, Mary P. Stenzel-Poore
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 285:E889-E898
Two receptors activated by the corticotropin-releasing factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle. To understand the role of the
Autor:
Robert J. Isfort, Glenda J. Lovell, Bernard E. Weissman, Daniel Gioeli, Claus Jens Doersen, David B. Cody
Publikováno v:
Molecular Carcinogenesis. 25:30-41
Using a series of tumorigenic and non-tumorigenic somatic cell hybrids that resulted from the fusion of the human osteosarcoma cell line OHS50-P16T (P16T) with the HeLa cell line D98OR, we investigated the role that genetic mutations, including alter
Autor:
W.G. Richards, Richard P. Woychik, Sharon B. Stuard, C. Miller, David B. Cody, Robert J. Isfort, Gregg M. Ridder, J.E. Wilkinson, C.J. Randall, Doersen Cj, Bradley K. Yoder
Publikováno v:
ResearcherID
Mouse liver stem cell (oval cell) lines were investigated in order to determine the role which two families of growth and differentiation factors (GDFs), epidermal growth factor (EGF) family and transforming growth factor beta (TGF-beta) family, play
Autor:
Richard P. Woychik, W G Richards, Klounig Je, Kier Ld, Isenberg Js, Doersen Cj, John E. Wilkinson, David B. Cody, Bradley K. Yoder, Randy L. Jirtle, Robert J. Isfort
Publikováno v:
Oncogene. 15:1797-1803
The Tg737 gene was investigated for gross alterations in a series of rodent/human liver tumors and human tumorigenic cell lines. The Tg737 gene was found to be altered in approximately 40% of the rodent chemically-induced liver tumors, 40% of the hum