Zobrazeno 1 - 10
of 28
pro vyhledávání: '"David B. Chou"'
Autor:
David B. Chou, Brooke A. Furlong, Ryan R. Posey, Christos Kyprianou, Lucy R. O’Sullivan, Rhiannon David, Suzanne J. Randle, Urszula M. Polanska, Jon Travers, Jelena Urosevic, John N. Hutchinson, Jianwei Che, Anna M. Howley, Robert P. Hasserjian, Rachelle Prantil-Baun, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Patients treated with Aurora kinase inhibitors experience dose-limiting neutropenia while other cytopenias are rare. Here, Chou et al. show that this cell-type specific side effect is partly explained by loss of drug efflux pump expression during neu
Externí odkaz:
https://doaj.org/article/30b138eaa22049aea33459bc0a7f87f2
Autor:
Alexandra Sontheimer-Phelps, David B. Chou, Alessio Tovaglieri, Thomas C. Ferrante, Taylor Duckworth, Cicely Fadel, Viktoras Frismantas, Arlene D. Sutherland, Sasan Jalili-Firoozinezhad, Magdalena Kasendra, Eric Stas, James C. Weaver, Camilla A. Richmond, Oren Levy, Rachelle Prantil-Baun, David T. Breault, Donald E. Ingber
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 507-526 (2020)
Background & Aims: The mucus layer in the human colon protects against commensal bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal disorders, such as ulcerative colitis. However, our understanding of colon
Externí odkaz:
https://doaj.org/article/554b633ff25042a892b30b69e190d4cd
Autor:
Pichet Praveschotinunt, Anna M. Duraj-Thatte, Ilia Gelfat, Franziska Bahl, David B. Chou, Neel S. Joshi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Anti-inflammatory treatments for gastrointestinal diseases can often have detrimental side effects. Here the authors engineer E. coli Nissle 1917 to create a fibrous matrix that has a protective effect in DSS-induced colitis mice.
Externí odkaz:
https://doaj.org/article/da22cd1382ed4f4c88ee9a65f788efef
Autor:
Alessio Tovaglieri, Alexandra Sontheimer-Phelps, Annelies Geirnaert, Rachelle Prantil-Baun, Diogo M. Camacho, David B. Chou, Sasan Jalili-Firoozinezhad, Tomás de Wouters, Magdalena Kasendra, Michael Super, Mark J. Cartwright, Camilla A. Richmond, David T. Breault, Christophe Lacroix, Donald E. Ingber
Publikováno v:
Microbiome, Vol 7, Iss 1, Pp 1-21 (2019)
Abstract Background Species-specific differences in tolerance to infection are exemplified by the high susceptibility of humans to enterohemorrhagic Escherichia coli (EHEC) infection, whereas mice are relatively resistant to this pathogen. This intri
Externí odkaz:
https://doaj.org/article/76b721f3cb93444bb33fc22d0b887943
Autor:
Curtis C. Harris, Alan G. Casson, Masao Miyashita, Xin Wei Wang, Nobutoshi Hagiwara, Anuradha Budhu, Yiqiang Zhao, Kensuke Kumamoto, Ewy A. Mathé, Jason E. Hawkes, Ronghua Zhao, Elise D. Bowman, David B. Chou, Aaron J. Schetter, Giang Huong Nguyen
Purpose: Esophageal cancer is one of the most aggressive and deadly forms of cancer; highlighting the need to identify biomarkers for early detection and prognostic classification. Our recent studies have identified inflammatory gene and microRNA sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f91d16420c04e48e188c30ef3311ac
https://doi.org/10.1158/1078-0432.c.6519185.v1
https://doi.org/10.1158/1078-0432.c.6519185.v1
Autor:
Anna Herland, Ben Swenor, Daniel Levner, Olivier Y.F. Henry, Sasan Jalili-Firoozinezhad, Angeliki Chalkiadaki, Henry Sanchez, Andrzej Przekwas, Sauveur S. F. Jeanty, Rachelle Prantil-Baun, Josiah Sliz, Youngjae Choe, Kyung-Jin Jang, Moran Yadid, Susan Marquez, Chris Hinojosa, Thomas C. Ferrante, Blakely B. O'Connor, Tiama Hamkins-Indik, Rachel Fleming, Stephanie Dauth, Janna Nawroth, Morgan Burt, Ben M. Maoz, David B. Chou, Aaron Delahanty, John P. Ferrier, Anthony Bahinski, Jose Fernandez-Alcon, Bret Nestor, Guy Robert Thompson, Lian Leng, Robert Mannix, Michael J. Cronce, Yuka Milton, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Tae-Eun Park, Miles Ingram, Edward A. FitzGerald, Debarun Das, Ville J. Kujala, Josue A. Goss, George J. Touloumes, Toni Divic, Carlos F. Ng, Oren Levy, Zachary Tranchemontagne, Elizabeth Calamari, Geraldine A. Hamilton, Alexander Cho, Thomas Grevesse, Norman Wen, Tessa Huffstater, Donald E. Ingber, Kevin Kit Parker, Richard M. Novak
Publikováno v:
Nature Biomedical Engineering. 4:407-420
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s
Autor:
David B. Chou, Rachelle Prantil-Baun, Ben Swenor, Sasan Jalili-Firoozinezhad, Andrzej Przekwas, Susan Marquez, Tessa Huffstater, Donald E. Ingber, Ben M. Maoz, Anna Herland, Michael J. Cronce, Yuka Milton, Angeliki Chalkiadaki, Miles Ingram, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Oren Levy, Sauveur S. F. Jeanty, Richard M. Novak, Aaron Delahanty, Kevin Kit Parker, Debarun Das
Publikováno v:
Nature Biomedical Engineering. 4:421-436
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. Here, we show that physiolog
Autor:
Thomas C. Ferrante, Viktoras Frismantas, Donald E. Ingber, David T. Breault, Sasan Jalili-Firoozinezhad, David B. Chou, Cicely Fadel, Magdalena Kasendra, James C. Weaver, Eric Stas, Rachelle Prantil-Baun, Oren Levy, Camilla A. Richmond, Alexandra Sontheimer-Phelps, Arlene D. Sutherland, Taylor Duckworth, Alessio Tovaglieri
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 507-526 (2020)
Background & Aims: The mucus layer in the human colon protects against commensal bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal disorders, such as ulcerative colitis. However, our understanding of colon
Autor:
Petar Pop-Damkov, Rhiannon David, Arianna Rech, Lucy R. O’Sullivan, Susan Marquez, Brooke A. Furlong, Douglas Ferguson, Kasiani C. Myers, Amanda Jiang, Liliana Moreira Teixeira, Oren Levy, Youngjae Choe, Özge Vargel Bölükbaşı, David B. Chou, Richard M. Novak, Olga K. Weinberg, Carl D. Novina, Robert P. Hasserjian, Lorna Ewart, Yuka Milton, Cailin E. Joyce, Viktoras Frismantas, Elizabeth Calamari, Sasan Jalili-Firoozinezhad, Rachelle Prantil-Baun, Donald E. Ingber, Alexander MacDonald, Akiko Shimamura, Carlos F. Ng
Publikováno v:
Nature biomedical engineering
The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a vascularized human BM-on-a-chip (BM chip) supports the differentiat
Autor:
David B. Chou, Anna M. Duraj-Thatte, Neel Joshi, Franziska Bahl, Ilia Gelfat, Pichet Praveschotinunt
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Mucosal healing plays a critical role in combatting the effects of inflammatory bowel disease, fistulae and ulcers. While most treatments for such diseases focus on systemically delivered anti-inflammatory drugs, often leading to detrimental side eff