Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David B. Brzozowski"'
Autor:
David B. Brzozowski, Ronald L. Hanson, Michael K. Wong, Dana L Cazzulino, Steven L. Goldberg, Thomas P. Tully, Truc Chi Vu, Ramesh N. Patel, William L. Parker, Olav Lyngberg
Publikováno v:
Advanced Synthesis & Catalysis. 349:1369-1378
The non-proteinogenic amino acid 2-(3-hydroxy-1-adamantyl)-(2S)-aminoethanoic acid [2, (S)-3-hydroxyadamantylglycine], is a key intermediate required for the synthesis of Saxagliptin, a dipeptidyl peptidase IV inhibitor under development for treatmen
Autor:
Ronald L. Hanson, Ramesh N. Patel, William L. Parker, David B. Brzozowski, Atul S. Kotnis, Mark Liu, Thomas P. Tully
Publikováno v:
Tetrahedron: Asymmetry. 16:2711-2716
6-Hydroxybuspirone is an active metabolite of the antianxiety drug buspirone. The (R)- and (S)-enantiomers of 6-hydroxybuspirone were prepared using an enzymatic resolution process. l -Amino acid acylase from Aspergillus melleus (Amano Acylase 30000)
Publikováno v:
Advanced Synthesis & Catalysis. 345:830-834
A new enzymatic process for the enantioselective cleavage of N-benzyloxycarbonyl (Cbz) groups from protected amino acids and related compounds has been developed. The Cbz-deprotecting enzyme was isolated from cell extracts of Sphingomonas paucimobili
Autor:
Robert J. Johnston, Ramesh N. Patel, Ronald L. Hanson, Jeffrey M. Howell, Amit Banerjee, Rapheal Ko, Mary-Jo Donovan, Animesh Goswami, Dana L Cazzulino, Steven L. Goldberg, David B. Brzozowski, Venkata B. Nanduri, Thomas P. Tully
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 30:252-259
There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutica
Autor:
Laporte Thomas L, Ramesh N. Patel, Ronald L. Hanson, David B. Brzozowski, Dane M. Springer, James A. Matson
Publikováno v:
Organic Process Research & Development. 6:482-487
Biotransformation of mutilin and pleuromutilin by microbial cultures was investigated to provide a source of 8-hydroxymutilin or 8-hydroxypleuromutilin. LC/MS analysis of culture broths showed that...
Autor:
Jeffrey M. Howell, David B. Brzozowski, Ronald F Eiring, R. N. Patel, Venkata B. Nanduri, Abhisek Banerjee
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 25:171-175
The 2-ketoreductase from Gluconobacter oxydans (SC 13851) catalyzes the reduction of 2-pentanone to (S)-(+)-2-pentanol. The 2-ketoreductase was purified 295-fold to homogeneity from G. oxydans cell extracts. The purified 2-ketoreductase had a molecul
Autor:
Shankar Swaminathan, Ramesh N. Patel, Clyde G. McNamee, John J. Venit, Larry W Parker, Venkata B. Nanduri, Robert M. Johnston, Thomas P. Tully, David B. Brzozowski, Ronald L. Hanson, Laporte Thomas L, Chien-Kuang Chen, Dana L Cazzulino, Steven L. Goldberg, Ko Raphael Y, Amit Banerjee
Publikováno v:
Enzyme and Microbial Technology. 27:376-389
[4S-(4I,7I,10aJ)]1-Octahydro-5-oxo-4-[phenylmethoxy)carbonyl]amino]-7H-pyrido-[2,1-b] [1,3]thiazepine-7-carboxylic acid methyl ester (BMS-199541-01) is a key chiral intermediate for the synthesis of Omapatrilat (BMS-186716), a new vasopeptidease inhi
Autor:
Clyde G. McNamee, Bang-Chi Chen, Ronald L. Hanson, Gus A. Kodersha, Amit Banerjee, Mark D. Schwinden, Ramesh N. Patel, David R. Kronenthal, David B. Brzozowski, Bharat P. Patel, Laszlo J. Szarka
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:2247-2252
L-6-Hydroxynorleucine, a key chiral intermediate used for synthesis of a vasopeptidase inhibitor, was prepared in 89% yield and > 99% optical purity by reductive amination of 2-keto-6-hydroxyhexanoic acid using glutamate dehydrogenase from beef liver
Autor:
Larry W Parker, David B. Brzozowski, Amit Banerjee, Ramesh N. Patel, Ronald L. Hanson, Laszlo J. Szarka
Publikováno v:
Tetrahedron: Asymmetry. 10:31-36
The chiral intermediates (S)-3,4-dihydro-1,2(2H)-pyridinedicarboxylic acid, 1-(phenylmethyl)ester [BMS 202665-01] and (S)-3,4-dihydro-1,2(2H)-pyridinedicarboxylic acid, 1,1-dimethylethyl ester [BMS 264406-01] were prepared by oxidation of Nα-carbobe
Publikováno v:
Tetrahedron: Asymmetry. 8:2547-2552
The chiral intermediate (1S,2R) [3-chloro-2-hydroxy-1-(phenylmethyl)propyl] carbamic acid, 1,1-dimethylethyl ester 2a was prepared for the total synthesis of an HIV protease inhibitor, BMS-186318. The stereoselective reduction of (1S) [3-chloro-2-oxo