Výsledky vyhledávání - "David B. Batt"

Heregulin Induces Phosphorylation of BRCA1 through Phosphatidylinositol 3-Kinase/AKT in Breast Cancer Cells

Autor: Soner Altiok, Nedret Altiok, Hava Avraham, Thomas M. Roberts, Anna Papautsky, Julian Downward, David B. Batt

Publikováno v: Journal of Biological Chemistry. 274:32274-32278

The breast cancer susceptibility gene BRCA1 encodes a nuclear phosphoprotein that acts as a tumor suppressor. Phosphorylation of BRCA1 has been implicated in altering its function, however, the pathway(s) that leads to the phosphorylation of BRCA1 ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dafbaff1cdf5a1b07b12e67b4a17dfd
https://doi.org/10.1074/jbc.274.45.32274

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Characterization of the Polyomavirus Late Polyadenylation Signal

Autor: Gordon G. Carmichael, David B. Batt

Publikováno v: Molecular and Cellular Biology. 15:4783-4790

The polyomavirus late polyadenylation signal is used inefficiently during the late phase of a productive viral infection. Inefficient polyadenylation serves an important purpose for viral propagation, as it allows a splicing event that stabilizes lat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d72f0cb41ec35c03d25b0345cb4464f
https://doi.org/10.1128/mcb.15.9.4783

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Targeted nuclear antisense RNA mimics natural antisense-induced degradation of polyoma virus early RNA

Autor: David B. Batt, Zhong Liu, Gordon G. Carmichael

Publikováno v: Proceedings of the National Academy of Sciences. 91:4258-4262

We describe a general antisense strategy to inhibit target gene expression. The substitution of a cis-acting ribozyme for a polyadenylylation signal in an antisense expression vector results in the nuclear retention of RNAs and the efficient degradat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913770a71cf345148e81cd0dae3ec36b
https://doi.org/10.1073/pnas.91.10.4258

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Polyadenylation and transcription termination in gene constructs containing multiple tandem polyadenylation signals

Autor: Gordon G. Carmichael, Ying Luo, David B. Batt

Publikováno v: Nucleic Acids Research. 22:2811-2816

The processes of pre-mRNA 3'-end cleavage and polyadenylation have been closely linked to transcription termination by RNA polymerase II. We have studied the relationship between polyadenylation and transcription termination in gene constructs contai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1f308a6dc5b0350c6a56b0000a4c83
https://doi.org/10.1093/nar/22.14.2811

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Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway

Autor: David B. Batt, Kurt R. Auger, Heidi L. Elliott, Grace Y. Hwang, Thomas M. Roberts, Charles D. Stiles, Palma Iannarelli, John A. Alberta, Rebecca Duke

Publikováno v: The Journal of biological chemistry. 274(43)

Platelet-derived growth factor (PDGF) stimulates transcription of an immediate-early gene set in Balb/c 3T3 cells. One cohort of these genes, typified by c-fos, is induced within minutes following activation of PDGF receptors. A second cohort respond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0166f4f2c76116617828f1a25e8524f8
https://pubmed.ncbi.nlm.nih.gov/10521506

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Homogeneous purification of human recombinant GST-Akt/PKB from Sf9 cells

Autor: Barbara Schacher, P. E. Rose, David B. Batt, Doriano Fabbro, Thomas M. Roberts, Stefano Ferrari

Publikováno v: Protein expression and purification. 17(1)

The plethora of extracellular stimuli modulating the status of a cell results in the engagement of relatively few pathways responsible for transducing signals to the interior of the cell. One such pathway is the activation of phosphatidylinositol 3-k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e7e2ab72bfbe922ed31d0cbab2761f
https://pubmed.ncbi.nlm.nih.gov/10497072

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

Autor: David B. Batt, Sauni P. Perera, Noriaki Nakamura, Thomas M. Roberts, Shivapriya Ramaswamy, William R. Sellers, Francisca Vazquez

PTEN/MMAC1is a tumor suppressor gene located on chromosome 10q23. InheritedPTEN/MMAC1mutations are associated with a cancer predisposition syndrome known as Cowden’s disease. Somatic mutation of PTEN has been found in a number of malignancies, incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3af30ce77ec98aa84fc871321ed3ec
https://europepmc.org/articles/PMC26745/

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Cell density modulates protein-tyrosine phosphorylation

Autor: David B. Batt, Thomas M. Roberts

Publikováno v: The Journal of biological chemistry. 273(6)

The growth of normal cells is arrested at saturating cell density in a process termed contact inhibition. An understanding of how cells communicate their contact with one another is critical for determining how cancers develop and spread. Because the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9cf7f9e6fb87375a60a32e0e8bed4c
https://pubmed.ncbi.nlm.nih.gov/9452462

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