Zobrazeno 1 - 10
of 317
pro vyhledávání: '"David B Sattelle"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011595 (2024)
Insecticide resistance is a serious threat to our ability to control mosquito vectors which transmit pathogens including malaria parasites and arboviruses. Understanding the underlying mechanisms is an essential first step in tackling the challenges
Externí odkaz:
https://doaj.org/article/52c5d4a0e1fc4c2ba57bddb4613cef1c
Autor:
Avril Coghlan, Frederick A Partridge, María Adelaida Duque-Correa, Gabriel Rinaldi, Simon Clare, Lisa Seymour, Cordelia Brandt, Tapoka T Mkandawire, Catherine McCarthy, Nancy Holroyd, Marina Nick, Anwen E Brown, Sirapat Tonitiwong, David B Sattelle, Matthew Berriman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011205 (2023)
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for oth
Externí odkaz:
https://doaj.org/article/a9399883925e4c239ce6cfe85ef5286d
Autor:
Yuma Komori, Koichi Takayama, Naoki Okamoto, Masaki Kamiya, Wataru Koizumi, Makoto Ihara, Daitaro Misawa, Kotaro Kamiya, Yuto Yoshinari, Kazuki Seike, Shu Kondo, Hiromu Tanimoto, Ryusuke Niwa, David B Sattelle, Kazuhiko Matsuda
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010522 (2023)
Neonicotinoid insecticides target insect nicotinic acetylcholine receptors (nAChRs) and their adverse effects on non-target insects are of serious concern. We recently found that cofactor TMX3 enables robust functional expression of insect nAChRs in
Externí odkaz:
https://doaj.org/article/ed05b338d6af43318002425c280f53b0
Autor:
Steven D Buckingham, Frederick A Partridge, Beth C Poulton, Benjamin S Miller, Rachel A McKendry, Gareth J Lycett, David B Sattelle
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0008639 (2021)
Pyrethroid-impregnated nets have contributed significantly to halving the burden of malaria but resistance threatens their future efficacy and the pipeline of new insecticides is short. Here we report that an invertebrate automated phenotyping platfo
Externí odkaz:
https://doaj.org/article/646eab1af88341da972b15d8a84768ef
Autor:
Frederick A Partridge, Ruth Forman, Nicky J Willis, Carole J R Bataille, Emma A Murphy, Anwen E Brown, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J C Sowood, Graham M Wynne, Kathryn J Else, Angela J Russell, David B Sattelle
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006487 (2018)
The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance. Current drugs such as mebendazole have a notable lack of efficacy
Externí odkaz:
https://doaj.org/article/dbfa1530a47d45d9ab4a45f4e2a752df
Autor:
Frederick A Partridge, Emma A Murphy, Nicky J Willis, Carole J R Bataille, Ruth Forman, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J C Sowood, Graham M Wynne, Kathryn J Else, Angela J Russell, David B Sattelle
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005359 (2017)
Trichuris trichiura is a human parasitic whipworm infecting around 500 million people globally, damaging the physical growth and educational performance of those infected. Current drug treatment options are limited and lack efficacy against the worm,
Externí odkaz:
https://doaj.org/article/90bbd18dd7814532925a0e5702303111
Autor:
Jose De La Fuente, Robert M Waterhouse, Daniel E. Sonenshine, R. Michael Roe, Jose Ribeiro, David B Sattelle, Catherine A Hill
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)
As tick-borne diseases are on the rise, an international effort resulted in the sequence and assembly of the first genome of a tick vector. This result promotes research on comparative, functional and evolutionary genomics and the study of tick-host-
Externí odkaz:
https://doaj.org/article/9db0b8e5c8ca4db8bce9651c54fb1b32
Autor:
Eleonora Khabirova, Aileen Moloney, Stefan J Marciniak, Julie Williams, David A Lomas, Stephen G Oliver, Giorgio Favrin, David B Sattelle, Damian C Crowther
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102985 (2014)
The human Aβ peptide causes progressive paralysis when expressed in the muscles of the nematode worm, C. elegans. We have exploited this model of Aβ toxicity by carrying out an RNAi screen to identify genes whose reduced expression modifies the sev
Externí odkaz:
https://doaj.org/article/59f5395e1eb941d4808ef402ed75ac77
Autor:
Susan K Glendinning, Steven D Buckingham, David B Sattelle, Susan Wonnacott, Adrian J Wolstenholme
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22390 (2011)
Anthelmintic resistance is a major problem in livestock farming, especially of small ruminants, but our understanding of it has been limited by the difficulty in carrying out functional genetic studies on parasitic nematodes. An important nematode in
Externí odkaz:
https://doaj.org/article/a662dd775a1b4dd0ad04aaf05fc29d7a
Autor:
Sally M Williamson, Alan P Robertson, Laurence Brown, Tracey Williams, Debra J Woods, Richard J Martin, David B Sattelle, Adrian J Wolstenholme
Publikováno v:
PLoS Pathogens, Vol 5, Iss 7, p e1000517 (2009)
Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasit
Externí odkaz:
https://doaj.org/article/221d850dab8b405b84f62b1d11491fcd