Zobrazeno 1 - 10
of 169
pro vyhledávání: '"David B Olsen"'
Autor:
Nicholas Murgolo, Alex G Therien, Bonnie Howell, Daniel Klein, Kenneth Koeplinger, Linda A Lieberman, Gregory C Adam, Jessica Flynn, Philip McKenna, Gokul Swaminathan, Daria J Hazuda, David B Olsen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009225 (2021)
Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally. While the effects of SARS-CoV-2 infection are not completely unde
Externí odkaz:
https://doaj.org/article/6909c68dee10406c8b165a62d0e69a18
Autor:
Trevor J Morin, Teresa J Broering, Brett A Leav, Barbra M Blair, Kirk J Rowley, Elisabeth N Boucher, Yang Wang, Peter S Cheslock, Michael Knauber, David B Olsen, Steve W Ludmerer, Gyongyi Szabo, Robert W Finberg, Robert H Purcell, Robert E Lanford, Donna M Ambrosino, Deborah C Molrine, Gregory J Babcock
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002895 (2012)
Hepatitis C virus (HCV) infection is a leading cause of liver transplantation and there is an urgent need to develop therapies to reduce rates of HCV infection of transplanted livers. Approved therapeutics for HCV are poorly tolerated and are of limi
Externí odkaz:
https://doaj.org/article/8744314b7609471e91dbe560c056d0b8
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease
Autor:
Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTAlthough smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak. While medical countermeasures (MCMs) previously approved by the Food
Externí odkaz:
https://doaj.org/article/53df8f67d29d4344baea9e9e6311d3a1
Autor:
Nadine Alvarez, Gregory C. Adam, John A. Howe, Vijeta Sharma, Matthew D. Zimmerman, Enriko Dolgov, Risha Rasheed, Fatima Nizar, Khushboo Sahay, Andrew M. Nelson, Steven Park, Xiaoyan Zhou, Christine Burlein, John F. Fay, Daniel V. Iwamoto, Carolyn M. Bahnck-Teets, Krista L. Getty, Shih Lin Goh, Imad Salhab, Keith Smith, Christopher W. Boyce, Tamara D. Cabalu, Nicholas Murgolo, Nicholas G. Fox, Todd W. Mayhood, Valerie W. Shurtleff, Mark E. Layton, Craig A. Parish, John A. McCauley, David B. Olsen, David S. Perlin
Publikováno v:
Viruses, Vol 16, Iss 7, p 1158 (2024)
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to be a global threat due to its ability to evolve and generate new subvariants, leading to new waves of infection. Additionally, other coronaviruses like Middle East respira
Externí odkaz:
https://doaj.org/article/5a441246ad714e97bc953aaa660b6bd5
Autor:
Manuel de Lera Ruiz, Paola Favuzza, Zhuyan Guo, Lianyun Zhao, Bin Hu, Zhiyu Lei, Dongmei Zhan, Nicholas Murgolo, Christopher W. Boyce, Marissa Vavrek, Jennifer Thompson, Anna Ngo, Kate E. Jarman, Johnathan Robbins, Justin Boddey, Brad E. Sleebs, Kym N. Lowes, Alan F. Cowman, David B. Olsen, John A. McCauley
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1745-1754
Drug resistance to first-line antimalarials-including artemisinin-is increasing, resulting in a critical need for the discovery of new agents with novel mechanisms of action. In collaboration with the Walter and Eliza Hall Institute and with funding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5c87b18003c3926bf80d926fcdff26
https://doi.org/10.1021/acsmedchemlett.2c00355
https://doi.org/10.1021/acsmedchemlett.2c00355
Autor:
Ben Gold, Jun Zhang, Landys Lopez Quezada, Julia Roberts, Yan Ling, Madeleine Wood, Wasima Shinwari, Laurent Goullieux, Christine Roubert, Laurent Fraisse, Eric Bacqué, Sophie Lagrange, Bruno Filoche-Rommé, Michal Vieth, Philip A. Hipskind, Louis N. Jungheim, Jeffrey Aubé, Sarah M. Scarry, Stacey L. McDonald, Kelin Li, Andrew Perkowski, Quyen Nguyen, Véronique Dartois, Matthew Zimmerman, David B. Olsen, Katherine Young, Shilah Bonnett, Douglas Joerss, Tanya Parish, Helena I. Boshoff, Kriti Arora, Clifton E. Barry, Laura Guijarro, Sara Anca, Joaquín Rullas, Beatriz Rodríguez-Salguero, Maria S. Martínez-Martínez, Esther Porras-De Francisco, Monica Cacho, David Barros-Aguirre, Paul Smith, Steven J. Berthel, Carl Nathan, Robert H. Bates
Publikováno v:
ACS Infectious Diseases. 8:557-573
Rising antimicrobial resistance challenges our ability to combat bacterial infections. The problem is acute for tuberculosis (TB), the leading cause of death from infection before COVID-19. Here, we developed a framework for multiple pharmaceutical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fbb240736098b21d77522307cf2134
https://doi.org/10.1021/acsinfecdis.1c00570
https://doi.org/10.1021/acsinfecdis.1c00570
Autor:
Abdeldjalil Madani, Dereje A. Negatu, Abdellatif El Marrouni, Randy R. Miller, Christopher Boyce, Nicholas Murgolo, Christopher J. Bungard, Matthew D. Zimmerman, Véronique Dartois, Martin Gengenbacher, David B. Olsen, Thomas Dick
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Tricyclic pyrrolopyrimidines (TPPs) are a new class of antibacterials inhibiting the ATPase of DNA gyrase. TPP8, a representative of this class, is active against Mycobacterium abscessus in vitro. Spontaneous TPP8 resistance mutations mapped to the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37177682f6362f871ef2526a318de268
https://doi.org/10.1128/aac.00669-22
https://doi.org/10.1128/aac.00669-22
Autor:
Melissa D. Chengalroyen, Mandy K. Mason, Alessandro Borsellini, Raffaella Tassoni, Garth L. Abrahams, Sasha Lynch, Yong-Mo Ahn, Jon Ambler, Katherine Young, Brendan M. Crowley, David B. Olsen, Digby F. Warner, Clifton E. Barry III, Helena I. M. Boshoff, Meindert H. Lamers, Valerie Mizrahi
Publikováno v:
ACS Infectious Diseases, 8(3), 612-625. AMER CHEMICAL SOC
Natural products provide a rich source of potential antimicrobials for treating infectious diseases for which drug resistance has emerged. Foremost among these diseases is tuberculosis. Assessment of the antimycobacterial activity of nargenicin, a na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fb2ed0c508f40ee8c1ebeb5a93f63a
https://hdl.handle.net/1887/3514350
https://hdl.handle.net/1887/3514350
Autor:
Sheo B. Singh, Christopher M. Tan, David Kaelin, Peter T. Meinke, Lynn Miesel, David B. Olsen, Hideyuki Fukuda, Ryuta Kishii, Masaya Takei, Kohei Ohata, Tomoko Takeuchi, Taku Shibue, Hisashi Takano, Akinori Nishimura, Yasumichi Fukuda
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
Novel bacterial topoisomerase inhibitors (NBTIs) are the newest members of gyrase inhibitor broad-spectrum antibacterial agents, represented by the most advanced member, gepotidacin, a 4-amino-piperidine linked NBTI, which is undergoing phase III cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88fe127252145bd1368ad8cd0c89f1d
https://pubmed.ncbi.nlm.nih.gov/35609741
https://pubmed.ncbi.nlm.nih.gov/35609741
Autor:
Melissa D, Chengalroyen, Mandy K, Mason, Alessandro, Borsellini, Raffaella, Tassoni, Garth L, Abrahams, Sasha, Lynch, Yong-Mo, Ahn, Jon, Ambler, Katherine, Young, Brendan M, Crowley, David B, Olsen, Digby F, Warner, Clifton E, Barry Iii, Helena I M, Boshoff, Meindert H, Lamers, Valerie, Mizrahi
Publikováno v:
ACS infectious diseases. 8(3)
Natural products provide a rich source of potential antimicrobials for treating infectious diseases for which drug resistance has emerged. Foremost among these diseases is tuberculosis. Assessment of the antimycobacterial activity of nargenicin, a na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b64455ca74c05abd995614158f98e672
https://pubmed.ncbi.nlm.nih.gov/35143160
https://pubmed.ncbi.nlm.nih.gov/35143160