Zobrazeno 1 - 10
of 92
pro vyhledávání: '"David B MacLeod"'
Autor:
Christopher K Willie, Michael Stembridge, Ryan L Hoiland, Michael M Tymko, Joshua C Tremblay, Alexander Patrician, Craig Steinback, Jonathan Moore, James Anholm, Prajan Subedi, Shailesh Niroula, Chris J McNeil, Ali McManus, David B MacLeod, Philip N Ainslie
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204660 (2018)
The University of British Columbia Nepal Expedition took place over several months in the fall of 2016 and was comprised of an international team of 37 researchers. This paper describes the objectives, study characteristics, organization and manageme
Externí odkaz:
https://doaj.org/article/4cca0ba07d064427bc8c651c3a6e9de1
Autor:
Greg S. Martin, David A. Kaufman, Paul E. Marik, Nathan I. Shapiro, Denny Z. H. Levett, John Whittle, David B. MacLeod, Desiree Chappell, Jonathan Lacey, Tom Woodcock, Kay Mitchell, Manu L. N. G. Malbrain, Tom M. Woodcock, Daniel Martin, Chris H. E. Imray, Michael W. Manning, Henry Howe, Michael P. W. Grocott, Monty G. Mythen, Tong J. Gan, Timothy E. Miller
Publikováno v:
Perioperative Medicine, Vol 9, Iss 1, Pp 1-12 (2020)
Abstract Background Optimal fluid therapy in the perioperative and critical care settings depends on understanding the underlying cardiovascular physiology and individualizing assessment of the dynamic patient state. Methods The Perioperative Quality
Externí odkaz:
https://doaj.org/article/05b8a6c2162e4e63acba9662dadc823b
Autor:
Jay MJR Carr, Philip N Ainslie, David B MacLeod, Joshua C Tremblay, Daniela Nowak-Flück, Connor A Howe, Mike Stembridge, Alexander Patrician, Geoff B Coombs, Benjamin S Stacey, Damian M Bailey, Daniel J Green, Ryan L Hoiland
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 43:99-114
This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) in 11 healthy males (age; 28 ± 7 years: body mass inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e240a0f8e294cee21d2691e7c6f9b6b
https://doi.org/10.1177/0271678x221119442
https://doi.org/10.1177/0271678x221119442
Autor:
Hannah G Caldwell, Ryan L Hoiland, Kurt J Smith, Patrice Brassard, Anthony R Bain, Michael M Tymko, Connor A Howe, Jay MJR Carr, Benjamin S Stacey, Damian M Bailey, Audrey Drapeau, Mypinder S Sekhon, David B MacLeod, Philip N Ainslie
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:559-571
This study investigated trans-cerebral internal jugular venous-arterial bicarbonate ([HCO3−]) and carbon dioxide tension (PCO2) exchange utilizing two separate interventions to induce acidosis: 1) acute respiratory acidosis via elevations in arteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1654d072eafac15c20b12ce19a658131
https://doi.org/10.1177/0271678x211065924
https://doi.org/10.1177/0271678x211065924
Autor:
Rachel Stone, David B. MacLeod, Philip N. Ainslie, John D. Akins, Michael M. Tymko, Anthony R Bain, Joshua C. Tremblay, Christopher A. DeSouza
Publikováno v:
The Journal of Physiology. 600:1373-1383
Key points Vascular dysfunction has been demonstrated in lowlanders at high-altitude (>4,000 m), however the extent of impairment and the delineation of contributing mechanisms have remained unclear. Using the gold-standard isolated perfused forearm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc8874b1a865a63e448c261b07f7c39
https://doi.org/10.1113/jp282281
https://doi.org/10.1113/jp282281
Autor:
Stephen A. McClave, Paul E. Wischmeyer, David B. MacLeod, Jeroen Molinger, Laura E. Niederer, Krista Haines, John Whittle, Hilary D. Miller
Publikováno v:
Clinical Nutrition Espen
Background & aims Indirect calorimetry (IC) is the gold-standard for determining measured resting energy expenditure (mREE) in critical illness. When IC is not available, predicted resting energy expenditure (pREE) equations are commonly utilized, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec39391bc346a41b288b7f6f777cb86
https://doi.org/10.1016/j.clnesp.2021.07.021
https://doi.org/10.1016/j.clnesp.2021.07.021
Autor:
Jay Mjr, Carr, Philip N, Ainslie, David B, MacLeod, Joshua C, Tremblay, Daniela, Nowak-Flück, Connor A, Howe, Mike, Stembridge, Alexander, Patrician, Geoff B, Coombs, Benjamin S, Stacey, Damian M, Bailey, Daniel J, Green, Ryan L, Hoiland
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 43(1)
This study investigated the influence of acute reductions in arterial O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e80277b5f7462c3088f6f14cb604df6
https://pubmed.ncbi.nlm.nih.gov/36131560
https://pubmed.ncbi.nlm.nih.gov/36131560
Autor:
Philip N. Ainslie, Mike Stembridge, Samuel J. E. Lucas, Christopher K. Willie, David B. MacLeod, Ryan L. Hoiland, Kurt J. Smith, Hannah G. Caldwell, Keith R. Burgess, Nia C. S. Lewis
Publikováno v:
The Journal of Physiology. 599:3513-3530
KEY POINTS We investigated the influence of arterial PCO2 (PaCO2 ) with and without experimentally altered pH on cerebral blood flow (CBF) regulation at sea level and with acclimatization to 5050 m. At sea level and high altitude, we assessed stepwis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e6b6a9f2ec60159529bd58029f19a5a
https://doi.org/10.1113/jp281446
https://doi.org/10.1113/jp281446
Autor:
Ryan L Hoiland, David B MacLeod, Benjamin S Stacey, Hannah G Caldwell, Connor A Howe, Daniela Nowak-Flück, Jay MJR Carr, Michael M Tymko, Geoff B Coombs, Alexander Patrician, Joshua C Tremblay, Michelle Van Mierlo, Chris Gasho, Mike Stembridge, Mypinder S Sekhon, Damian M Bailey, Philip N Ainslie
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. :0271678X2311695
Cerebral hypoxic vasodilation is poorly understood in humans, which undermines the development of therapeutics to optimize cerebral oxygen delivery. Across four investigations (total n = 195) we investigated the role of nitric oxide (NO) and hemoglob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0735928c930d4c294f81af4b91d639b5
https://doi.org/10.1177/0271678x231169579
https://doi.org/10.1177/0271678x231169579
Autor:
David B. MacLeod, Giovanfrancesco Varoli, Alexandra M. Williams, Christopher Gasho, Philip N. Ainslie, Mike Stembridge, Daniela Nowak-Flück, Alexander Patrician, Lindsay K. Eller, Michael M. Tymko, Gordon Binsted, Prajan Subedi, Ryan L. Hoiland, Emily McBride, Raylene A. Reimer, Christopher K. Willie, Sawyer Plato, James D. Anholm, Aimee L. Drane
Publikováno v:
The Journal of Physiology. 599:1685-1708
Key points Iron acts as a cofactor in the stabilization of the hypoxic-inducible factor family, and likely plays an influential role in the modulation of hypoxic pulmonary vasoconstriction. It is uncertain whether iron regulation is altered in lowlan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b948a46534be9803eae01f9d2d43ffc3
https://doi.org/10.1113/jp281114
https://doi.org/10.1113/jp281114