Zobrazeno 1 - 10 of 120 pro vyhledávání: '"David B Jaffe"'
1
Akademický článek
Dorsal root ganglia control nociceptive input to the central nervous system.
Autor: Han Hao, Rosmaliza Ramli, Caixue Wang, Chao Liu, Shihab Shah, Pierce Mullen, Varinder Lall, Frederick Jones, Jicheng Shao, Hailin Zhang, David B Jaffe, Nikita Gamper, Xiaona Du
Publikováno v: PLoS Biology, Vol 21, Iss 1, p e3001958 (2023)
Accumulating observations suggest that peripheral somatosensory ganglia may regulate nociceptive transmission, yet direct evidence is sparse. Here, in experiments on rats and mice, we show that the peripheral afferent nociceptive information undergoe
Externí odkaz: https://doaj.org/article/c537901d0434420a87a4bcff108dbe55
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2
Akademický článek
Downregulation of KCNMB4 expression and changes in BK channel subtype in hippocampal granule neurons following seizure activity.
Autor: Luke E Whitmire, Ling Ling, Vladslav Bugay, Chase M Carver, Santosh Timilsina, Hui-Hsiu Chuang, David B Jaffe, Mark S Shapiro, Jose E Cavazos, Robert Brenner
Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188064 (2017)
A major challenge is to understand maladaptive changes in ion channels that sets neurons on a course towards epilepsy development. Voltage- and calcium-activated K+ (BK) channels contribute to early spike timing in neurons, and studies indicate that
Externí odkaz: https://doaj.org/article/d4f281d15dae414db4babdee93ae8b4e
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3
Akademický článek
Current understanding of iberiotoxin-resistant BK channels in the nervous system
Autor: Bin eWang, David B Jaffe, Robert eBrenner
Publikováno v: Frontiers in Physiology, Vol 5 (2014)
While most large-conductance, calcium- and voltage-activated potassium channels (BK or Maxi-K type) are blocked by the scorpion venom iberiotoxin, the so-called type II subtype has the property of toxin resistance. This property is uniquely mediated
Externí odkaz: https://doaj.org/article/e68aceeedfe34e8dba623670b790249c
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4
Akademický článek
Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes
Autor: Jonathan Hurtado, Thomas F. Rogers, David B. Jaffe, Bruce A. Adams, Sandhya Bangaru, Elijah Garcia, Tazio Capozzola, Terrence Messmer, Pragati Sharma, Ge Song, Nathan Beutler, Wanting He, Katharina Dueker, Rami Musharrafieh, Sarah Burbach, Alina Truong, Michael J.T. Stubbington, Dennis R. Burton, Raiees Andrabi, Andrew B. Ward, Wyatt J. McDonnell, Bryan Briney
Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114307- (2024)
Summary: The development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. We screened the circulating B cell repertoires of COVID-19 survivors and vaccinees to isolate over 9,000
Externí odkaz: https://doaj.org/article/f79894ea6aa64842a740394d85fccf3e
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5
Functional antibodies exhibit light chain coherence
Autor: David B. Jaffe, Payam Shahi, Bruce A. Adams, Ashley M. Chrisman, Peter M. Finnegan, Nandhini Raman, Ariel E. Royall, FuNien Tsai, Thomas Vollbrecht, Daniel S. Reyes, N. Lance Hepler, Wyatt J. McDonnell
Publikováno v: Nature. 611:352-357
The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens1. In most mammals, antibodies are composed of heavy and light chains that are generated sequentially by recombination o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35d6489358e6f3877a19040f9a3c09dc
https://doi.org/10.1038/s41586-022-05371-z
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7
Dorsal root ganglia control nociceptive input to the central nervous system
Autor: Han Hao, Rosmaliza Ramli, Caixue Wang, Chao Liu, Shihab Shah, Pierce Mullen, Varinder Lall, Frederick Jones, Jicheng Shao, Hailin Zhang, David B. Jaffe, Nikita Gamper, Xiaona Du
Publikováno v: PLoS biology. 21(1)
Accumulating observations suggest that peripheral somatosensory ganglia may regulate nociceptive transmission, yet direct evidence is sparse. Here, in experiments on rats and mice, we show that the peripheral afferent nociceptive information undergoe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece162d47c8dbeb4e6d7f1d3acd4acad
https://pubmed.ncbi.nlm.nih.gov/36603052
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8
enclone: precision clonotyping and analysis of immune receptors
Autor: David B. Jaffe, Payam Shahi, Bruce A. Adams, Ashley M. Chrisman, Peter M. Finnegan, Nandhini Raman, Ariel E. Royall, FuNien Tsai, Thomas Vollbrecht, Daniel S. Reyes, Wyatt J. McDonnell
Half a billion years of evolutionary battle forged the vertebrate adaptive immune system, an astonishingly versatile factory for molecules that can adapt to arbitrary attacks. The history of an individual encounter is chronicled within a clonotype: t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e36f265ad02187663fcdce7bb2f98aff
https://doi.org/10.1101/2022.04.21.489084
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9
Dorsal root ganglia control nociceptive input to the central nervous system
Autor: Ramli R, Caiyan Wang, Shao J, Pierce Mullen, Nikita Gamper, Han H, Hailin Zhang, Shihab Shah, Liu C, Frederick Jones, Lall, Xiaona Du, David B. Jaffe
Accumulating observations suggest that peripheral somatosensory ganglia may regulate pain transmission, yet direct evidence is sparse. Here we show that the peripheral afferent nociceptive information undergoes dynamic filtering within dorsal root ga
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee2b4fc56d3946dadb5f0b7ed0f628f5
https://doi.org/10.1101/2021.07.14.452325
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10
Genomic architecture and introgression shape a butterfly radiation
Autor: Marcus R. Kronforst, Daniel E. Neafsey, Gilson R. P. Moreira, Brian A. Counterman, W. Owen McMillan, David B. Jaffe, John W. Davey, Michael Miyagi, Bernardo J. Clavijo, Gonzalo García-Accinelli, Nathaniel B. Edelman, Andrew J. Blumberg, Riccardo Papa, Robert D. Reed, Mark Blaxter, Steven M. Van Belleghem, Camilo Salazar, James Mallet, Richard Challis, Federica Di Palma, Paul B. Frandsen, Nick Patterson, Kanchon K. Dasmahapatra, Sujai Kumar, Mathieu Chouteau, Chris D. Jiggins, Mathieu Joron, Rebecca B. Dikow, John Wakeley
Publikováno v: Science (0036-8075) (Amer Assoc Advancement Science), 2019-11, Vol. 366, N. 6465, P. 594-599
Science
Science, 2019, 366 (6465), pp.594-599. ⟨10.1126/science.aaw2090⟩
Science, American Association for the Advancement of Science, 2019, 366 (6465), pp.594-599. ⟨10.1126/science.aaw2090⟩
Science, American Association for the Advancement of Science, 2019, ⟨10.1126/science.aaw2090⟩
Science, American Association for the Advancement of Science, 2019, ⟨10.1126/science.aaw2090 ⟩
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Edelman, N B, Frandsen, P B, Miyagi, M, Clavijo, B, Davey, J, Dikow, R B, García-Accinelli, G, Van Belleghem, S M, Patterson, N, Neafsey, D E, Challis, R, Kumar, S, Moreira, G R P, Salazar, C, Chouteau, M, Counterman, B A, Papa, R, Blaxter, M, Reed, R D, Dasmahapatra, K K, Kronforst, M, Joron, M, Jiggins, C D, McMillan, W O, Di Palma, F, Blumberg, A J, Wakeley, J, Jaffe, D & Mallet, J 2019, ' Genomic architecture and introgression shape a butterfly radiation ', Science (New York, N.Y.), vol. 366, no. 6465, pp. 594-599 . https://doi.org/10.1126/science.aaw2090
We here pioneer a low-cost assembly strategy for 20 Heliconiini genomes to characterize the evolutionary history of the rapidly radiating genusHeliconius. A bifurcating tree provides a poor fit to the data, and we therefore explore a reticulate phylo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ea9b6fed722a35afb941a4ec7eb6a3
https://archimer.ifremer.fr/doc/00659/77116/
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