Zobrazeno 1 - 10
of 143
pro vyhledávání: '"David B Haslam"'
Autor:
Nicole M Chumbler, Melissa A Farrow, Lynne A Lapierre, Jeffrey L Franklin, David B Haslam, James R Goldenring, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1003072 (2012)
Clostridium difficile is the most common cause of antibiotic-associated nosocomial infection in the United States. C. difficile secretes two homologous toxins, TcdA and TcdB, which are responsible for the symptoms of C. difficile associated disease.
Externí odkaz:
https://doaj.org/article/55dc2988305d4c528c22204846810d6e
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Background Identification of pathogenic bacteria from clinical specimens and evaluating their antimicrobial resistance (AMR) are laborious tasks that involve in vitro cultivation, isolation, and susceptibility testing. Recently, a number of
Externí odkaz:
https://doaj.org/article/70f1b56372fd4daa89d32ea0e19f00cf
Autor:
Lauren Bodilly, Lauren Williamson, Patrick Lahni, Matthew N. Alder, David B. Haslam, Jennifer M. Kaplan
Publikováno v:
Innate Immunity, Vol 29 (2023)
Sepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with survival. Six-week
Externí odkaz:
https://doaj.org/article/2f601ae8b55f479b8c22a48d1ff3137a
Autor:
Tzu-Yu Shao, Tony T. Jiang, Joseph Stevens, Abigail E. Russi, Ty D. Troutman, Anas Bernieh, Giang Pham, John J. Erickson, Emily M. Eshleman, Theresa Alenghat, Stephen C. Jameson, Kristin A. Hogquist, Casey T. Weaver, David B. Haslam, Hitesh Deshmukh, Sing Sing Way
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113323- (2023)
Summary: Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion of CD4 T cells unified by the Kruppel-like factor 2 (KLF2) transcriptional regulat
Externí odkaz:
https://doaj.org/article/44014ddf1b0d48c8b50adc38b432ca17
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background Aberrations in the preterm microbiome following antibiotic therapy have been reported in previous studies. The objective of this study was to probe potential underlying mechanisms between this observation and susceptibility to adv
Externí odkaz:
https://doaj.org/article/7f48219bbd124f648f203244b26d896c
Autor:
Emily M. Eshleman, Tzu-Yu Shao, Vivienne Woo, Taylor Rice, Laura Engleman, Bailey J. Didriksen, Jordan Whitt, David B. Haslam, Sing Sing Way, Theresa Alenghat
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Aberrant immune responses to resident microbes promote inflammatory bowel disease and other chronic inflammatory conditions. However, how microbiota-specific immunity is controlled in mucosal tissues remains poorly understood. Here, we found that mic
Externí odkaz:
https://doaj.org/article/9020d0eccbb047c8940d96aee38825dc
Autor:
Tzu-Yu Shao, Pallavi Kakade, Jessica N. Witchley, Corey Frazer, Kathryn L. Murray, Iuliana V. Ene, David B. Haslam, Thomas Hagan, Suzanne M. Noble, Richard J. Bennett, Sing Sing Way
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110837- (2022)
Summary: Systemic immunity is stringently regulated by commensal intestinal microbes, including the pathobiont Candida albicans. This fungus utilizes various transcriptional and morphological programs for host adaptation, but how this heterogeneity a
Externí odkaz:
https://doaj.org/article/9febbd1082cc40c5a74bef0cdea24015
Autor:
Arun Jose, Senu Apewokin, Walaa E. Hussein, Nicholas J. Ollberding, Jean M. Elwing, David B. Haslam
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract Pulmonary arterial hypertension (PAH) is a progressive, ultimately fatal cardiopulmonary disease associated with a number of physiologic changes, which is believed to result in imbalances in the intestinal microbiota. To date, comprehensive
Externí odkaz:
https://doaj.org/article/6981c707314340e0bcd770a5641aacc5
Autor:
Michelle Lowe, Marleen M. Kock, Jennifer Coetzee, Ebrahim Hoosien, Gisele Peirano, Kathy-Ann Strydom, Marthie M. Ehlers, Nontombi M. Mbelle, Elena Shashkina, David B. Haslam, Puneet Dhawan, Robert J. Donnelly, Liang Chen, Barry N. Kreiswirth, Johann D.D. Pitout
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 4, Pp 739-747 (2019)
Klebsiella pneumoniae sequence type (ST) 307 is an emerging global antimicrobial drug–resistant clone. We used whole-genome sequencing and PCR to characterize K. pneumoniae ST307 with oxacillinase (OXA) 181 carbapenemase across several private hosp
Externí odkaz:
https://doaj.org/article/ac1effafb11f4c618bc0d74e077e954c
Autor:
Adrienne N. Wilburn, Jaclyn W. McAlees, David B. Haslam, Simon Graspeuntner, Inken Schmudde, Yves Laumonnier, Jan Rupp, Claire A. Chougnet, Hitesh Deshmukh, William J. Zacharias, Peter König, Ian P. Lewkowich
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:498-510
Microbial maturation disrupted by early life dysbiosis has been linked with increased asthma risk and severity, however the immunological mechanisms underpinning this connection are poorly understood. We sought to understand how delaying microbial ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cd98dd90e531c0b6d6421bd825eb91
https://doi.org/10.1165/rcmb.2022-0367oc
https://doi.org/10.1165/rcmb.2022-0367oc