Zobrazeno 1 - 10
of 94
pro vyhledávání: '"David B Darr"'
Autor:
Sneha eSundaram, Trinh L Le, Luma eEssaid, Alex J Freemerman, Megan J Huang, Joseph A Galanko, Kirk K McNaughton, Katharine M Bendt, David B Darr, Melissa A Troester, Liza eMakowski
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
Epidemiologic studies demonstrate that obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). Using the C3(1)-TAg murine model of BBC, we previously demonstrated that mice displayed an early onset of
Externí odkaz:
https://doaj.org/article/9462c1b4bf7544548fbc19c165474948
Autor:
Sneha Sundaram, Alex J Freemerman, Joseph A Galanko, Kirk K McNaughton, Katharine M Bendt, David B Darr, Melissa A Troester, Liza Makowski
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111394 (2014)
It is widely thought that pregnancy reduces breast cancer risk, but this lacks consideration of breast cancer subtypes. While a full term pregnancy reduces risk for estrogen receptor positive (ER+) and luminal breast cancers, parity is associated wit
Externí odkaz:
https://doaj.org/article/cafbdcb4569544c7ab5c8713d48e81ce
Autor:
Norman E. Sharpless, Sharon L. Campbell, Bruce C. Baguley, Michael J. Miley, Daniel C. Zedek, David B. Darr, George P. Souroullas, William R. Jeck, Brit L. Martin, Kailing Fu, Kelly S. Clark, James E. Gillahan, Meriam A. Waqas, Minh V. Huynh, Wenjin Liu, Christin E. Burd
Figure S1. Generation of the LSL-N-RasQ61R allele. Figure S2. Conditional expression of N-Ras mutants does not alter melanocyte morphology. Figure S3. In both the heterozygous and homozygous state, NRasG12D fails to induce melanoma formation. Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5c3e3adfbf56270fa607f7d8df27f8
https://doi.org/10.1158/2159-8290.22530242.v1
https://doi.org/10.1158/2159-8290.22530242.v1
Autor:
Norman E. Sharpless, Sharon L. Campbell, Bruce C. Baguley, Michael J. Miley, Daniel C. Zedek, David B. Darr, George P. Souroullas, William R. Jeck, Brit L. Martin, Kailing Fu, Kelly S. Clark, James E. Gillahan, Meriam A. Waqas, Minh V. Huynh, Wenjin Liu, Christin E. Burd
NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an NrasQ61R knock-in allele to similarly designed KrasG12D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b07545ea77a4bfaa05fa90bb50b2e69
https://doi.org/10.1158/2159-8290.c.6546137.v1
https://doi.org/10.1158/2159-8290.c.6546137.v1
Autor:
James E. Bear, Gary L. Johnson, Norman E. Sharpless, Michael L. Gatza, Noah Sciaky, Kubra Karagoz, David B. Darr, Alicia C. Tagliatela, Jose Roques, Tao Bo, Steven P. Angus, Hailey E. Brighton
Expanded detail on MIB MS experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2c066efb2308edfb15303cc7f4e858
https://doi.org/10.1158/0008-5472.22418124
https://doi.org/10.1158/0008-5472.22418124
Autor:
James E. Bear, Gary L. Johnson, Norman E. Sharpless, Michael L. Gatza, Noah Sciaky, Kubra Karagoz, David B. Darr, Alicia C. Tagliatela, Jose Roques, Tao Bo, Steven P. Angus, Hailey E. Brighton
Structural reorganization and amelanotic intratumoral nests are evident in persistent melanoma on MEKi.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a4e87ab2bd3ad8eff0f6219dfe75f1
https://doi.org/10.1158/0008-5472.22418130.v1
https://doi.org/10.1158/0008-5472.22418130.v1
Autor:
Norman E. Sharpless, Charles M. Perou, Gary L. Johnson, William C. Zamboni, Jian Jin, Austin J. Combest, Soren M. Johnson, James S. Duncan, Martin C. Whittle, Adam D. Pfefferle, Patrick M. Dillon, David B. Darr, Jerry E. Usary, Patrick J. Roberts
PDF file, 53K, MP1U Dosing Regimens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06aab9f024e8516676b9d1a778432315
https://doi.org/10.1158/1078-0432.22455326.v1
https://doi.org/10.1158/1078-0432.22455326.v1
Autor:
James E. Bear, Gary L. Johnson, Norman E. Sharpless, Michael L. Gatza, Noah Sciaky, Kubra Karagoz, David B. Darr, Alicia C. Tagliatela, Jose Roques, Tao Bo, Steven P. Angus, Hailey E. Brighton
Kinome and transcriptome responses to combined BRAF and MEK inhibition in murine tumors, patient samples, and human cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7752ce357e3add8e25523de79714aa
https://doi.org/10.1158/0008-5472.22418118
https://doi.org/10.1158/0008-5472.22418118
Autor:
William C. Zamboni, Charles M. Perou, Andrew C. Dudley, Arlin B. Rogers, Teresa K. Tarrant, C. Ryan Miller, Nana Nikolaishvili-Feinberg, Stephanie Cohen, Bentley R. Midkiff, Jamie L. Jordan, Alain Valdivia, Mark Ross, Charlene M. Santos, David B. Darr, Gina Song
Supplementary Fig. S3. Profiling of collagen in basal-like C3-TAg model and claudin-low T11 model at baseline and at 96 h after administration of PLD or NL-doxo at 6 mg/kg I.V. x 1 via tail vein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc71154b91cc2042f3442bd51e4b8470
https://doi.org/10.1158/1078-0432.22456287.v1
https://doi.org/10.1158/1078-0432.22456287.v1
Autor:
William C. Zamboni, Charles M. Perou, Andrew C. Dudley, Arlin B. Rogers, Teresa K. Tarrant, C. Ryan Miller, Nana Nikolaishvili-Feinberg, Stephanie Cohen, Bentley R. Midkiff, Jamie L. Jordan, Alain Valdivia, Mark Ross, Charlene M. Santos, David B. Darr, Gina Song
Supplementary Data. Table S1. Product information from FormuMax Scientific, Inc. Table S2. Doxorubicin AUC0-96h in plasma, tissues, and tumor in the C3-TAg model and the T11 model after PLD or NL-doxo administration at 6 mg/kg I.V. x 1 via tail vein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5eef07a6263cca0d09627ab18668a7
https://doi.org/10.1158/1078-0432.22456296.v1
https://doi.org/10.1158/1078-0432.22456296.v1