Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David Böhme"'
This book contains the revised selected papers of 4 workshops held in conjunction with the International Conference on High Performance Computing, Networking, Storage and Analysis (SC) in November 2017 in Denver, CO, USA, and in November 2018 in Dall
Publikováno v:
ACM Transactions on Parallel Computing. 3:1-24
Driven by growing application requirements and accelerated by current trends in microprocessor design, the number of processor cores on modern supercomputers is increasing from generation to generation. However, load or communication imbalance preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cef3ff18c460d924e3dc765b3b6cf3ce
https://doi.org/10.1145/2934661
https://doi.org/10.1145/2934661
Publikováno v:
Journal of Medicinal Chemistry. 59:3409-3417
Bioconjugates containing the neuropeptide Y (NPY) analogue [F(7),P(34)]-NPY as targeting moiety are able to deliver toxic agents specifically to breast cancer cells that overexpress the human Y1-receptor (hY1R). To increase their activity, multiple t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb63952f971a084c21ea73f8983eaa4
https://doi.org/10.1021/acs.jmedchem.6b00043
https://doi.org/10.1021/acs.jmedchem.6b00043
Autor:
David Böhme, Annette G. Beck-Sickinger
Publikováno v:
Journal of Peptide Science. 21:186-200
Most toxic agents currently used for chemotherapy show a narrow therapeutic window, because of their inability to distinguish between healthy and cancer cells. Targeted drug delivery offers the possibility to overcome this issue by selectively addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10b6b458c796dfade4cfa6b888ce9e05
https://doi.org/10.1002/psc.2753
https://doi.org/10.1002/psc.2753
Autor:
Misbah Mubarak, Noah Wolfe, Todd Gamblin, Louis H. Howell, Nikhil Jain, Edgar A. León, David Böhme, Matthew L. Leininger, Ian Karlin, Abhinav Bhatele
Publikováno v:
SC
The fat-tree topology is one of the most commonly used network topologies in HPC systems. Vendors support several options that can be configured when deploying fat-tree networks on production systems, such as link bandwidth, number of rails, number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::997739a8b5df1c505ff6347062b94295
https://doi.org/10.1145/3126908.3126967
https://doi.org/10.1145/3126908.3126967
Publikováno v:
Parallel Processing Letters. 20:397-414
Cray XT and IBM Blue Gene systems present current alternative approaches to constructing leadership computer systems relying on applications being able to exploit very large configurations of processor cores, and associated analysis tools must also s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43dd0347c3204e2a406d67d80df4253b
https://doi.org/10.1142/s0129626410000314
https://doi.org/10.1142/s0129626410000314
Autor:
Bernd Hamann, Todd Gamblin, Katherine E. Isaacs, Martin Schulz, Peer-Timo Bremer, Abhinav Bhatele, Jonathan Lifflander, David Böhme
Publikováno v:
SC
Asynchrony and non-determinism in Charm++ programs present a significant challenge in analyzing their event traces. We present a new framework to organize event traces of parallel programs written in Charm++. Our reorganization allows one to more eas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9440b072563a91bef3130b9896e4e074
https://doi.org/10.1145/2807591.2807634
https://doi.org/10.1145/2807591.2807634
Autor:
Lutz Weber, Stefan Kalkhof, David Kosel, Katja B. Kostelnik, Annette G. Beck-Sickinger, David Böhme, Martin von Bergen, Robert C. Rennert, Verena M. Ahrens
Publikováno v:
Ahrens, V M, Kostelnik, K B, Rennert, R, Böhme, D, Kalkhof, S, Kosel, D, Weber, L, Von Bergen, M & Beck-Sickinger, A G 2015, ' A cleavable cytolysin-neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action ', Journal of Controlled Release, vol. 209, 7658, pp. 170-178 . https://doi.org/10.1016/j.jconrel.2015.04.037
Myxobacterial tubulysins are promising chemotherapeutics inhibiting microtubule polymerization, however, high unspecific toxicity so far prevents their application in therapy. For selective cancer cell targeting, here the coupling of a synthetic cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cb04fe9172d2c951c9e1356a746a0e
https://vbn.aau.dk/da/publications/962ddf9f-8396-4809-a5bc-4243fe13b936
https://vbn.aau.dk/da/publications/962ddf9f-8396-4809-a5bc-4243fe13b936
Autor:
Alfredo Gimenez, Abhinav Bhatele, Todd Gamblin, Katherine E. Isaacs, Martin Schulz, David Böhme, Peer-Timo Bremer
Publikováno v:
Tools for High Performance Computing 2014 ISBN: 9783319160115
Performance data can be complex and potentially high dimensional. Further, it can be collected in multiple, independent domains. For example, one can measure code segments, hardware components, data structures, or an application’s communication str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c306ffbc259012193577c6dae5be47e
https://doi.org/10.1007/978-3-319-16012-2_10
https://doi.org/10.1007/978-3-319-16012-2_10
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 21(3)
Most toxic agents currently used for chemotherapy show a narrow therapeutic window, because of their inability to distinguish between healthy and cancer cells. Targeted drug delivery offers the possibility to overcome this issue by selectively addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3de09e8f994da09f26ca52ce5d4175a
https://pubmed.ncbi.nlm.nih.gov/25703117
https://pubmed.ncbi.nlm.nih.gov/25703117