Zobrazeno 1 - 10
of 66
pro vyhledávání: '"David B, West"'
Autor:
Michael R. Bowl, Michelle M. Simon, Neil J. Ingham, Simon Greenaway, Luis Santos, Heather Cater, Sarah Taylor, Jeremy Mason, Natalja Kurbatova, Selina Pearson, Lynette R. Bower, Dave A. Clary, Hamid Meziane, Patrick Reilly, Osamu Minowa, Lois Kelsey, The International Mouse Phenotyping Consortium, Glauco P. Tocchini-Valentini, Xiang Gao, Allan Bradley, William C. Skarnes, Mark Moore, Arthur L. Beaudet, Monica J. Justice, John Seavitt, Mary E. Dickinson, Wolfgang Wurst, Martin Hrabe de Angelis, Yann Herault, Shigeharu Wakana, Lauryl M. J. Nutter, Ann M. Flenniken, Colin McKerlie, Stephen A. Murray, Karen L. Svenson, Robert E. Braun, David B. West, K. C. Kent Lloyd, David J. Adams, Jacqui White, Natasha Karp, Paul Flicek, Damian Smedley, Terrence F. Meehan, Helen E. Parkinson, Lydia M. Teboul, Sara Wells, Karen P. Steel, Ann-Marie Mallon, Steve D. M. Brown
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for
Externí odkaz:
https://doaj.org/article/c71478f2406844f6901b4df53eb1c02c
Autor:
David B West, Eric K Engelhard, Michael Adkisson, A J Nava, Julia V Kirov, Andreanna Cipollone, Brandon Willis, Jared Rapp, Pieter J de Jong, Kent C Lloyd
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005691 (2016)
The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects. Using RNA-seq, we evaluated targeted and ne
Externí odkaz:
https://doaj.org/article/6496b2606a6943efa0f0187ddd6c8ff0
Autor:
Alexander D. Borowsky, Padmavathi Bandhuvula, Ashok Kumar, Yuko Yoshinaga, Mikhail Nefedov, Loren G. Fong, Meng Zhang, Brian Baridon, Lisa Dillard, Pieter de Jong, Stephen G. Young, David B. West, Julie D. Saba
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 9, Pp 1920-1931 (2012)
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer. S
Externí odkaz:
https://doaj.org/article/e772a50f7a6e4145b1aa23fcda7480ac
Autor:
Natasha A Karp, Terry F Meehan, Hugh Morgan, Jeremy C Mason, Andrew Blake, Natalja Kurbatova, Damian Smedley, Julius Jacobsen, Richard F Mott, Vivek Iyer, Peter Matthews, David G Melvin, Sara Wells, Ann M Flenniken, Hiroshi Masuya, Shigeharu Wakana, Jacqueline K White, K C Kent Lloyd, Corey L Reynolds, Richard Paylor, David B West, Karen L Svenson, Elissa J Chesler, Martin Hrabě de Angelis, Glauco P Tocchini-Valentini, Tania Sorg, Yann Herault, Helen Parkinson, Ann-Marie Mallon, Steve D M Brown
Publikováno v:
PLoS Biology, Vol 13, Iss 5, p e1002151 (2015)
The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation o
Externí odkaz:
https://doaj.org/article/131b7bd1aeb343f7af3216b1eeb922cf
Autor:
Julia V Kirov, Michael Adkisson, A J Nava, Andreana Cipollone, Brandon Willis, Eric K Engelhard, K C Kent Lloyd, Pieter de Jong, David B West
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134155 (2015)
Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a group of six mutants carrying the tm1a Knockout Mouse Project allele containing both a LacZ
Externí odkaz:
https://doaj.org/article/bb67362f1ea14d198d4793e888e3eb46
Autor:
Steven J. Smith, Hongbing Zhang, Anne O. Clermont, Alvin C. Powers, Dixon B. Kaufman, Anthony F. Purchio, David B. West
Publikováno v:
Molecular Imaging, Vol 5 (2006)
We generated a transgenic mouse model ( RIP-luc ) for the in vivo monitoring of pancreatic islet mass and function in response to metabolic disease. Using the rat insulin promoter fused to firefly luciferase, and noninvasive technology to detect luci
Externí odkaz:
https://doaj.org/article/32f35fa541764f56b887df62fe16bffe
Publikováno v:
Molecular Imaging, Vol 4 (2005)
Many enzymes are therapeutic targets for drug discovery, whereas other enzymes are important for understanding drug metabolism and pharmacokinetics during compound testing in animals. Testing of drug efficacy and metabolism in an animal model require
Externí odkaz:
https://doaj.org/article/e830a2a59e31476986d5b0a26d495717
Autor:
Mary E, Dickinson, Ann M, Flenniken, Xiao, Ji, Lydia, Teboul, Michael D, Wong, Jacqueline K, White, Terrence F, Meehan, Wolfgang J, Weninger, Henrik, Westerberg, Hibret, Adissu, Candice N, Baker, Lynette, Bower, James M, Brown, L Brianna, Caddle, Francesco, Chiani, Dave, Clary, James, Cleak, Mark J, Daly, James M, Denegre, Brendan, Doe, Mary E, Dolan, Sarah M, Edie Helmut Fuchs, Valerie, Gailus-Durner, Antonella, Galli, Alessia, Gambadoro, Juan, Gallegos, Shiying, Guo, Neil R, Horner, Chih-Wei, Hsu, Sara J, Johnson, Sowmya, Kalaga, Lance C, Keith, Louise, Lanoue, Thomas N, Lawson, Monkol, Lek, Manuel, Mark, Susan, Marschall, Jeremy, Mason, Melissa L, McElwee, Susan Newbigging Lauryl M J, Nutter, Kevin A, Peterson, Ramiro, Ramirez-Solis, Douglas J, Rowland, Edward, Ryder, Kaitlin E, Samocha, John R, Seavitt, Mohammed, Selloum, Zsombor, Szoke-Kovacs, Masaru, Tamura, Amanda G, Trainor, Ilinca, Tudose, Shigeharu, Wakana, Jonathan, Warren, Olivia, Wendling, David B, West, Leeyean, Wong, Atsushi, Yoshiki, Wolfgang, Wurst, Daniel G, MacArthur, Glauco P, Tocchini-Valentini, Xiang, Gao, Paul, Flicek, Allan, Bradley, William C, Skarnes, Monica J, Justice, Helen E, Parkinson, Mark, Moore, Sara, Wells, Robert E, Braun, Karen L, Svenson, Martin Hrabe, de Angelis, Yann, Herault, Tim, Mohun, Ann-Marie, Mallon, R Mark, Henkelman, Steve D M, Brown, David J, Adams, K C Kent, Lloyd, Colin, McKerlie, Arthur L, Beaudet, Maja Bućan Stephen A, Murray
Publikováno v:
Nature
Approximately one third of all mammalian genes are essential for life. Phenotypes resulting from mouse knockouts of these genes have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotypi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74b5a3945655035b12ce6c274bdc013b
https://pubmed.ncbi.nlm.nih.gov/27626380
https://pubmed.ncbi.nlm.nih.gov/27626380
Autor:
Damian Smedley, Colin McKerlie, Xiang Gao, Henrik Westerberg, Simon Greenaway, Monica J. Justice, Hiroshi Masuya, Elissa J. Chesler, Robert E. Braun, Mary E. Dickinson, Shay Yaacoby, Stephen A. Murray, Karen L. Svenson, Jeremy Mason, Martin Hrabé de Angelis, Luis Santos, Tania Sorg, Christopher J. Lelliott, Sara Wells, Ann M. Flenniken, Ruth Heller, Ann-Marie Mallon, Lynette Bower, Karen P. Steel, Helen Parkinson, Judith E. Mank, Arthur L. Beaudet, Kevin C K Lloyd, Richard Mott, Yann Herault, Yoav Benjamini, Jacqueline K. White, Steve D.M. Brown, Shiying Guo, John R. Seavitt, Helmut Fuchs, Natalja Kurbatova, Anneliese O. Speak, Natasha A. Karp, Ramiro Ramirez-Solis, Terrence F. Meehan, David B. West, Shigeharu Wakana
Publikováno v:
Nature Communications
Nature Communications, 2017, 8, ⟨10.1038/ncomms15475⟩
Nature communications, vol 8, iss 1
Nat. Commun. 8:15475 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications, 2017, 8, ⟨10.1038/ncomms15475⟩
Nature communications, vol 8, iss 1
Nat. Commun. 8:15475 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22ff32917f16b5f536bab3a8bab6e17
https://hal.science/hal-03679179/file/islandora_77521.pdf
https://hal.science/hal-03679179/file/islandora_77521.pdf
Autor:
Chris J. Jung, Junli Zhang, Barry Rosen, Pieter J. de Jong, Kevin C K Lloyd, Elizabeth Trenchard, David B. West
Publikováno v:
Transgenic research, vol 26, iss 2
Transgenic Research
Transgenic Research
The CRISPR/Cas9 system has rapidly advanced targeted genome editing technologies. However, its efficiency in targeting with constructs in mouse zygotes via homology directed repair (HDR) remains low. Here, we systematically explored optimal parameter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07486db0bbf0e636709cbe51e5f98124
https://escholarship.org/uc/item/71c8d0x7
https://escholarship.org/uc/item/71c8d0x7