Zobrazeno 1 - 10
of 29
pro vyhledávání: '"David Ausländer"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Bacterial populations communicate with AI-2 signaling molecules, helping to coordinate biofilm development and other group behaviors. Here the authors design a genetic circuit for mammalian cells that allows them to sense bacterial populations and in
Externí odkaz:
https://doaj.org/article/f5b4f3ce5f3b40af8b18e1f0b070f445
Autor:
Hélène Chassin, Barbara Geering, Lina Schukur, David Ausländer, Brian Lang, Martin Fussenegger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The standard treatment for an allergic response is anti-histamines, steroids and anti-IgE antibodies. Here the authors present a genetic circuit that senses IL-4 and IL-13 and responses with DARPin production to bind IgE.
Externí odkaz:
https://doaj.org/article/33084c3c97df4da3aeedbbb2271d4033
Publikováno v:
ACS Synthetic Biology, 9 (11)
ACS Synthetic Biology
ACS Synthetic Biology
Synthetic biology relies on rapid and efficient methods to stably integrate DNA payloads encoding for synthetic biological systems into the genome of living cells. The size of designed biological systems increases with their complexity, and novel met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de45830e50ef810c4e5876efc035eee
https://doi.org/10.1021/acssynbio.0c00413
https://doi.org/10.1021/acssynbio.0c00413
Autor:
Katja, Glinšek, Lovro, Kramer, Aleksander, Krajnc, Eva, Kranjc, Nina, Pirher, Jaka, Marušič, Leon, Hellmann, Barbara, Podobnik, Borut, Štrukelj, David, Ausländer, Rok, Gaber
Publikováno v:
Biotechnology Journal. 17:2100499
Difficulties in obtaining and maintaining the desired level of the critical quality attributes (CQAs) of therapeutic proteins as well as the pace of the development are major challenges of current biopharmaceutical development. Therapeutic proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0827947dcd6b168365f1a153407e6a56
https://doi.org/10.1002/biot.202100499
https://doi.org/10.1002/biot.202100499
Publikováno v:
Angewandte Chemie. 129:6494-6519
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb5655438bb24e25704c2f4c4892f4d
https://doi.org/10.1002/ange.201609229
https://doi.org/10.1002/ange.201609229
Autor:
Adrian Britschgi, Martin Fussenegger, Zina Zokouri, Hans-Uwe Simon, David Ausländer, Barbara Geering, Bertran Gerrits, Samuel Hürlemann, Mario P. Tschan
Publikováno v:
Molecular and Cellular Biology. 36:132-143
Death-associated protein kinase 2 (DAPK2) is a Ca(2+)/calmodulin-dependent Ser/Thr kinase that possesses tumor-suppressive functions and regulates programmed cell death, autophagy, oxidative stress, hematopoiesis, and motility. As only few binding pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52c16bbc9562f3fd779c089311377b2
https://doi.org/10.1128/mcb.00515-15
https://doi.org/10.1128/mcb.00515-15
Publikováno v:
Angewandte Chemie. International Edition, 56 (23)
Synthetic biology envisages the engineering of man-made living biomachines from standardized components that can perform pre-defined functions in a (self-)controlled manner. Different research strategies and interdisciplinary efforts are pursued to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9d2d7ed9b710a3de328fefd4fea9b9
https://hdl.handle.net/20.500.11850/190531
https://hdl.handle.net/20.500.11850/190531
Autor:
Leon Hellmann, Leila Rachid, Simon Ausländer, Xavier Pierrat, Martin Fussenegger, David Ausländer
Publikováno v:
Nature methods. 15(1)
Synthetic biologists have advanced the design of trigger-inducible gene switches and their assembly into input-programmable circuits that enable engineered human cells to perform arithmetic calculations reminiscent of electronic circuits. By designin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffb6a4dd4830c6981f3f6897773f35e
https://pubmed.ncbi.nlm.nih.gov/29200199
https://pubmed.ncbi.nlm.nih.gov/29200199
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 9
Quorum sensing is a promising target for next-generation anti-infectives designed to address evolving bacterial drug resistance. The autoinducer-2 (AI-2) is a key quorum-sensing signal molecule which regulates bacterial group behaviors and is recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0429d3ebfc45ce1a92abc563a4d7168d
https://pubmed.ncbi.nlm.nih.gov/29739943
https://pubmed.ncbi.nlm.nih.gov/29739943
Publikováno v:
Apoptosis. 18:1093-1105
Noxa is a member of the pro-apoptotic BH3-only group of Bcl-2 proteins that is known to bind specifically to anti-apoptotic Mcl-1 and A1, antagonizing their function. Mcl-1 has been reported to have a short half-life, and Noxa up-regulation accelerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa621ca8d99a816a905ddbd47bb64cbc
https://doi.org/10.1007/s10495-013-0868-9
https://doi.org/10.1007/s10495-013-0868-9