Zobrazeno 1 - 10
of 94
pro vyhledávání: '"David Askin"'
Publikováno v:
Mesentery and Peritoneum. 5:AB200-AB200
Autor:
Barbara Müller, C. Gregory Sowell, Stefan G. Koenig, Francis Gosselin, Keena Green, David Askin
Publikováno v:
Tetrahedron. 79:131840
A practical route to PI3K α-selective inhibitor GDC-0326 is reported. The synthesis leverages an existing scheme to a key tetracyclic benzoxazepine intermediate and optimizes it for robustness and scalability, including removing numerous undesired c
Autor:
Sebastian Rieth, David Askin, Barbara Müller, C. Gregory Sowell, Nadja Neubauer, Michael Jansen, Francis Gosselin, Nicholas Wong, Stefan G. Koenig, Stephan Bachmann, Xin Linghu, Nathaniel L. Segraves, Ifat Abramovich, Serena Fantasia
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(12)
A practical synthesis of the complex payload for an anti-Staphylococcus aureus THIOMABTM antibody-antibiotic conjugate (TAC) is described. The route takes advantage of a delicate oxidative condensation, achieved using a semi-continuous flow procedure
Autor:
Qingping Tian, Ulrike Bromberger, Pirmin Hidber, Ursula Hoffmann, Herbert Yajima, Theresa Humphries, Zhigang Cheng, Maud Guillemot-Plass, Srinivasan Babu, Jane Li, Francis Gosselin, David Askin
Publikováno v:
Organic Process Research & Development. 19:416-426
We report a practical and protecting-group-free synthesis amenable to produce multikilogram amounts of PI3K/mTOR inhibitor GDC-0980. The route employed metalation/formylation and reductive aminatio...
Autor:
Frédéric St-Jean, Scott Savage, Keith Lee Spencer, Alan Deese, Brian Wong, Lane Jonathan W, David Askin, Herbert Yajima, Travis Remarchuk, Srinivasan Babu, Michael W. Dong, Jeffrey Stults, Diane E. Carrera
Publikováno v:
Organic Process Research & Development. 18:1652-1666
Herein, the first-generation process to manufacture Akt inhibitor Ipatasertib through a late-stage convergent coupling of two challenging chiral components on multikilogram scale is described. The ...
Publikováno v:
Rheumatology. 56
Autor:
Michelle Fitzgerald, David Askin, John F. Quinlan, Caitriona Cunningham, Tara Coughlan, Catherine Blake
Publikováno v:
International journal of orthopaedic and trauma nursing. 29
Objective Better patient outcomes and more efficient healthcare could be achieved by predicting post hip fracture function at an early stage. This study aimed to identify independent predictors of mobility outcome one week post hip fracture surgery.
Autor:
Theresa Humphries, Takashi Miki, Qingping Tian, Scott Savage, Zhigang Cheng, Yasuharu Shimasaki, Norihiko Hirata, Mark Reynolds, Mitsuhiro Iwasaki, Srinivasan Babu, David Askin, Francis Gosselin, Herbert Yajima, Keena Green, Isao Kurimoto
Publikováno v:
Organic Process Research & Development. 17:97-107
We report a practical synthesis of PI3K inhibitor GDC-0941. The synthesis was achieved using a convergent approach starting from a thienopyrimidine intermediate through a sequence of formylation and reductive amination followed by Suzuki-Miyaura cros
Publikováno v:
Community Oncology. 9:377-381
Autor:
Jack Ansell, David Askin
Publikováno v:
Current Drug Discovery Technologies. 9:150-155
Unfractionated heparin (UFH) and the vitamin K antagonists (VKA), have been standard anticoagulants for the last 70 years. They have a widespread effect on many coagulation factors, the serine proteases for UFH and the vitamin K dependent factors for