Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David Arribas-Layton"'
Autor:
Hai Nguyen, David Arribas-Layton, I-Ting Chow, Cate Speake, William W. Kwok, Martin J. Hessner, Carla J. Greenbaum, Eddie A. James
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionPrevious studies verify the formation of enzymatically post-translationally modified (PTM) self-peptides and their preferred recognition by T cells in subjects with type 1 diabetes (T1D). However, questions remain about the relative preva
Externí odkaz:
https://doaj.org/article/176aa63aeeca4531b95bd9d0a26130c9
Autor:
Jing Song, Anja Schwenzer, Alicia Wong, Sara Turcinov, Cliff Rims, Lorena Rodriguez Martinez, David Arribas-Layton, Christina Gerstner, Virginia S. Muir, Kim S. Midwood, Vivianne Malmström, Eddie A. James, Jane H. Buckner
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Tenascin-C (TNC), an extracellular matrix protein that has proinflammatory properties, is a recently described antibody target in rheumatoid arthritis (RA). In this study, we utilized a systematic discovery process and identified 5 potentially novel
Externí odkaz:
https://doaj.org/article/817bed96baa04ee0b9d77c2c5b9df132
Autor:
Erika Margaret Scholz, Miguel Marcilla, Xavier Daura, David Arribas-Layton, Eddie A. James, Iñaki Alvarez
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. It contains the two DRB* genes DRB1*1501 (DR2b) and DRB5*0101 (DR2a). The reported anchor motif of the corresponding HLA-DR molecules was determined in 1994 based o
Externí odkaz:
https://doaj.org/article/57848a499f4a4942966a9254dc1a4bf5
Autor:
I-Ting Chow, Kathryn Haskins, William W. Kwok, Eddie A. James, Thomas Delong, Cate Speake, David Arribas-Layton, Mylinh Dang, Perrin Guyer, Rocky L. Baker, Carla J. Greenbaum
Publikováno v:
Diabetes
T cells isolated from the pancreatic infiltrates of nonobese diabetic mice have been shown to recognize epitopes formed by the covalent cross-linking of proinsulin and secretory granule peptides. Formation of such hybrid insulin peptides (HIPs) was c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addd3a5fc69ce6e004c221e1278653c8
https://doi.org/10.2337/db19-0620
https://doi.org/10.2337/db19-0620
Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes
Autor:
Perrin Guyer, David Arribas-Layton, Anthony Manganaro, Cate Speake, Sandra Lord, Decio L. Eizirik, Sally C. Kent, Roberto Mallone, Eddie A. James
Publikováno v:
Diabetes.
Diabetes
Diabetes, 2022, Online ahead of print. ⟨10.2337/db22-0191⟩
Diabetes
Diabetes, 2022, Online ahead of print. ⟨10.2337/db22-0191⟩
A recent discovery effort resulted in identification of novel splice variant and secretory granule antigens within the HLA class I peptidome of human islets and documentation of their recognition by CD8+ T cells from peripheral blood and human islets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c7763675e445790b198d73024dc490
https://pubmed.ncbi.nlm.nih.gov/36201618
https://pubmed.ncbi.nlm.nih.gov/36201618
Autor:
Virginia S. Muir, Cliff Rims, Christina Gerstner, Jane H. Buckner, Vivianne Malmström, Lorena Rodriguez Martinez, Jing Song, Eddie A. James, Anja Schwenzer, Alicia Wong, David Arribas-Layton, Sara Turcinov, Kim S. Midwood
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
Tenascin-C (TNC), an extracellular matrix protein that has proinflammatory properties, is a recently described antibody target in rheumatoid arthritis (RA). In this study, we utilized a systematic discovery process and identified 5 potentially novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23135f053a497b41d0cd0963f17da85
https://doaj.org/article/817bed96baa04ee0b9d77c2c5b9df132
https://doaj.org/article/817bed96baa04ee0b9d77c2c5b9df132
Autor:
Eddie A. James, Kathryn Haskins, Rocky L. Baker, William W. Kwok, Carla J. Greenbaum, Cate Speake, I-Ting Chow, Mylinh Dang, Thomas Delong, Perrin Guyer, David Arribas-Layton, Ada Admin
T cells isolated from the pancreatic infiltrates of non-obese diabetic mice have been shown to recognize epitopes formed by the covalent cross-linking of proinsulin and secretory granule peptides. Formation of such hybrid insulin peptides (HIPs) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780c8b72f17103feb4ba5f1b7e4d233e
https://doi.org/10.2337/db20-4567/suppl.12103698.v1
https://doi.org/10.2337/db20-4567/suppl.12103698.v1
Autor:
Marco Liguori, Shuai Huang, Eddie A. James, David Arribas-Layton, Richard J. Auchus, Aaron W. Michels, Qin Ouyang, Roberto Gianani, Anna Casu, Liping Yu, Maria Acevedo-Calado, Massimo Pietropaolo, Marco Songini, Michael P. Morran, Susan L. Pietropaolo
Publikováno v:
Diabetes Care
OBJECTIVE The characterization of diverse subtypes of diabetes is a dynamic field of clinical research and an active area of discussion. The objective of this study was to identify new antigenic determinants in the neuroendocrine autoantigen IA-2 (IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e692a5638a69390d99f2e4ab7dbaf
https://doi.org/10.2337/dc16-1527
https://doi.org/10.2337/dc16-1527
Autor:
Mijke Buitinga, David Arribas-Layton, Eddie A. James, Jon D. Piganelli, Lut Overbergh, Aïsha Callebaut, Marco Bugliani, Chantal Mathieu, Dana P Cook, Rita Derua, Inne Crèvecoeur, Fernanda Marques Câmara Sodré, Etienne Waelkens, Mark J. Mamula, Gabriele Blahnik-Fagan, Mei-Ling Yang, Roberto Mallone, Meghan L. Marré, Piero Marchetti
Publikováno v:
Diabetes
The β-cell has become recognized as a central player in the pathogenesis of type 1 diabetes with the generation of neoantigens as potential triggers for breaking immune tolerance. We report that posttranslationally modified glucose-regulated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0606116ea5d97ac03dee7d21fd743909
https://lirias.kuleuven.be/handle/123456789/629210
https://lirias.kuleuven.be/handle/123456789/629210
Autor:
Hai T Nguyen, David Arribas-Layton, I-Ting Chow, Carla Greenbaum, Meghan L. Marre, Jon D Piganelli, William Kwok, Eddie A James
Publikováno v:
The Journal of Immunology. 196:54.21-54.21
Selective recognition of self-proteins that have undergone enzymatic post-translational modification (PTM) by CD4+ T cells is increasingly implicated as a means of potentiating the loss of tolerance in autoimmune diseases such as type 1 diabetes (T1D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97afe7e27f59f1c5714b1fb99bafe6b
https://doi.org/10.4049/jimmunol.196.supp.54.21
https://doi.org/10.4049/jimmunol.196.supp.54.21