Zobrazeno 1 - 10 of 132 pro vyhledávání: '"David Arnott"'
1
Akademický článek
Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation
Autor: Ryan Raisner, Samir Kharbanda, Lingyan Jin, Edwin Jeng, Emily Chan, Mark Merchant, Peter M. Haverty, Russell Bainer, Tommy Cheung, David Arnott, E. Megan Flynn, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne
Publikováno v: Cell Reports, Vol 24, Iss 7, Pp 1722-1729 (2018)
Summary: Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However, the functional impact of this modification at enhancers is poorly understood. Here, we use a chemical genetics approach to acutely block the funct
Externí odkaz: https://doaj.org/article/30f0b373eb01444dbff75e2a8755acdb
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2
Akademický článek
Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation
Autor: Denise E. de Almeida Nagata, Eugene Y. Chiang, Suchit Jhunjhunwala, Patrick Caplazi, Vidhyalakshmi Arumugam, Zora Modrusan, Emily Chan, Mark Merchant, Lingyan Jin, David Arnott, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne, Jane L. Grogan
Publikováno v: Cell Reports, Vol 27, Iss 1, Pp 269-281.e4 (2019)
Summary: Myeloid-derived suppressor cells (MDSCs) are found in most cancer malignancies and support tumorigenesis by suppressing immunity and promoting tumor growth. Here we identify the bromodomain (BRD) of CBP/EP300 as a critical regulator of H3K27
Externí odkaz: https://doaj.org/article/59bed4a4121e435abacf7f0ac7ad65fe
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3
Akademický článek
A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase
Autor: J. Hiroshi Morisaki, Peter A. Smith, Shailesh V. Date, Kimberly K. Kajihara, Chau Linda Truong, Zora Modrusan, Donghong Yan, Jing Kang, Min Xu, Ishita M. Shah, Robert Mintzer, Eric M. Kofoed, Tommy K. Cheung, David Arnott, Michael F. T. Koehler, Christopher E. Heise, Eric J. Brown, Man-Wah Tan, Wouter L. W. Hazenbos
Publikováno v: mBio, Vol 7, Iss 5 (2016)
ABSTRACT The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB
Externí odkaz: https://doaj.org/article/3b9f916136964f4eb118797ed067be1e
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4
Akademický článek
An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.
Autor: Brian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, Paul Labhart, Gulfem D Guler, David Arnott, Tobias M Maile, Jennifer Busby, Chisato Henry, Theresa K Kelly, Charles A Tindell, Suchit Jhunjhunwala, Feng Zhao, Charlie Hatton, Barbara M Bryant, Marie Classon, Patrick Trojer
Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166438 (2016)
Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require mo
Externí odkaz: https://doaj.org/article/626380f9c1534821baa58955f830b641
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5
Akademický článek
Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.
Autor: Travis W Bainbridge, Venita I DeAlmeida, Anita Izrael-Tomasevic, Cécile Chalouni, Borlan Pan, Joshua Goldsmith, Alia P Schoen, Gabriel A Quiñones, Ryan Kelly, Jennie R Lill, Wendy Sandoval, Mike Costa, Paul Polakis, David Arnott, Bonnee Rubinfeld, James A Ernst
Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102695 (2014)
Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the receptor tyrosine kinase (RTK) family and have been associated with several human diseases. The vertebrate RORs contain an ATP binding domain that deviates from
Externí odkaz: https://doaj.org/article/080290e22e094a90849ffe90a71ec97c
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6
Targeted degradation via direct 26S proteasome recruitment
Autor: Charlene Bashore, Sumit Prakash, Matthew C. Johnson, Ryan J. Conrad, Ivy A. Kekessie, Suzie J. Scales, Noriko Ishisoko, Tracy Kleinheinz, Peter S. Liu, Nataliya Popovych, Aaron T. Wecksler, Lijuan Zhou, Christine Tam, Inna Zilberleyb, Rajini Srinivasan, Robert A. Blake, Aimin Song, Steven T. Staben, Yingnan Zhang, David Arnott, Wayne J. Fairbrother, Scott A. Foster, Ingrid E. Wertz, Claudio Ciferri, Erin C. Dueber
Publikováno v: Nature Chemical Biology. 19:55-63
Engineered destruction of target proteins by recruitment to the cell’s degradation machinery has emerged as a promising strategy in drug discovery. The majority of molecules that facilitate targeted degradation do so via a select number of ubiquiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cffe718a8e978d9932a3400ef0703fa
https://doi.org/10.1038/s41589-022-01218-w
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10
Behavioral economics in information systems research: Critical analysis and research strategies
Autor: Shijia Gao, David Arnott
Publikováno v: Journal of Information Technology. 37:80-117
Theories of decision-making have long been important foundations for information systems research and much of the information system is concerned with information processing for decision-making. The discipline of behavioral economics provides the dom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c20487e05e9cd995b1d12cb9174bed95
https://doi.org/10.1177/02683962211016000
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