Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David Archer Ellis"'
Autor:
Samu Melkko, N. Jarousse, David Archer Ellis, Finton Sirockin, A. Bernardi, Aengus Mac Sweeney, Paul Erbel, Paul Ramage, Philipp Grosche, Eva Altmann, Keith D. Combrink, Nicola Hughes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:438-443
Adenoviral infections are associated with a wide range of acute diseases, among which ocular viral conjunctivitis (EKC) and disseminated disease in immunocompromised patients. To date, no approved specific anti-adenoviral drug is available, but there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3777095530490cc9447027eeafc558
https://doi.org/10.1016/j.bmcl.2014.12.057
https://doi.org/10.1016/j.bmcl.2014.12.057
Autor:
Eva Altmann, A. Bernardi, Paul Erbel, Aengus Mac Sweeney, N. Jarousse, Paul Ramage, Philipp Grosche, Keith D. Combrink, Nicola Hughes, David Archer Ellis, Samu Melkko, Finton Sirockin
Publikováno v:
ACS Medicinal Chemistry Letters. 5:937-941
The cysteine protease adenain is the essential protease of adenovirus and, as such, represents a promising target for the treatment of ocular and other adenoviral infections. Through a concise two-pronged hit discovery approach we identified tetrapep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c6b52f270b5d23e3714c30285f506a
https://doi.org/10.1021/ml500224t
https://doi.org/10.1021/ml500224t
Autor:
Karen S. MacMillan, Dale L. Boger, Kristopher E. Boyle, William M. Robertson, James P. Lajiness, David Archer Ellis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1854-1857
The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7929592a28249d5ebe3c0cd0e10600d7
https://doi.org/10.1016/j.bmcl.2010.01.145
https://doi.org/10.1016/j.bmcl.2010.01.145
Autor:
Laurie A. LeBrun, Mei Tsan, Yuefen Zhou, Frank Ruebsam, Darian M. Bartkowski, Alan X. Xiang, Ruhi Kamran, Lian-Sheng Li, Richard E. Showalter, Jingjing Zhao, Rupal Patel, Matthew Lardy, Maria V. Sergeeva, Stephen E. Webber, Amit M. Shah, David Archer Ellis, Zhongxiang Sun, Mcguire Helen, Julie Blazel, Leo Kirkovsky, Daniel A. Norris, Tran Chinh Viet, Charles R. Kissinger, Thomas G. Nolan, Peter S. Dragovich, Qing Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4628-4632
4-(1,1-Dioxo-1,4-dihydro-1lambda(6)-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-one analogs were discovered as a novel class of inhibitors of HCV NS5B polymerase. Structure-based design led to the identification of compound 3a that displayed pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11da5f58198cc1bc858c040e469b8f03
https://doi.org/10.1016/j.bmcl.2008.07.014
https://doi.org/10.1016/j.bmcl.2008.07.014
Autor:
David Archer Ellis, Karen Wolff, Yun He, Donald S. Karanewsky, Baogen Wu, Hong Yin, Jeremy S. Caldwell, Beth Anaclerio, Kelli L. Kuhen, Badry Bursulaya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4246-4251
A novel series of quinolones was discovered as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) using a structure-based approach. The lead quinolones exhibited single digit nanomolar potency in the HIV-1 replication assays. The prelimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ec91fdcd866b99ef9d483ae7309a20
https://doi.org/10.1016/j.bmcl.2006.05.073
https://doi.org/10.1016/j.bmcl.2006.05.073
Publikováno v:
Journal of the American Chemical Society. 123:9299-9306
The synthesis and examination of a novel class of reversed CPyI analogues of CC-1065 and the duocarmycins are described. Capable of a unique metal cation activation of DNA alkylation, these agents allowed the effects of the DNA binding domain (10(4)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bede0a711c5696d0c815f483c3a4228e
https://doi.org/10.1021/ja010769r
https://doi.org/10.1021/ja010769r
Autor:
Noble Michael A, Frank Ruebsam, Lian-Sheng Li, Julie Blazel, Yuefen Zhou, Rupal Patel, Stephen E. Webber, Qing Han, Tran Chinh Viet, Peter S. Dragovich, Maria V. Sergeeva, Charles R. Kissinger, Laurie A. LeBrun, Amit M. Shah, David Archer Ellis, Ruhi Kamran, Douglas E. Murphy, Richard E. Showalter, Mei Tsan, Leo Kirkovsky
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(20)
The synthesis of 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones bearing 6-amino substituents as potent inhibitors of the HCV RNA-dependent RNA polymerase (NS5B) is described. Several of these a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c763409b689428bd7bc63ab47fb168
https://pubmed.ncbi.nlm.nih.gov/18796353
https://pubmed.ncbi.nlm.nih.gov/18796353
Autor:
Tran Chinh Viet, Kimkim Dao, Frank Ruebsam, Lian-Sheng Li, David Archer Ellis, Julie K. Blazel, Peter S. Dragovich, Douglas E. Murphy, Yuefen Zhou
Publikováno v:
ChemInform. 39
The synthesis of a novel class of 6-amino-5-hydroxy-pyridazin-3(2 H)-ones (3-oxo-2,3-dihydropyridazines) is described. These compounds also contain an ethoxycarbonyl moiety at the 4-position of the pyridazinone ring. They are prepared in good to mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb7dc53d6258cbdd370b8154e5fd4d19
https://doi.org/10.1002/chin.200826160
https://doi.org/10.1002/chin.200826160
Autor:
Leo Kirkovsky, Julie Blazel, Tran Chinh Viet, Darian M. Bartkowski, Mei Tsan, Martin T. Tran, Stephen E. Webber, Douglas E. Murphy, Richard E. Showalter, David Archer Ellis, Qiang Zhao, Benjamin K. Ayida, Frank Ruebsam, Alberto Gobbi, Amit M. Shah, Alan X. Xiang, Rupal Patel, Charles R. Kissinger, Yuefen Zhou, Thomas G. Nolan, Daniel A. Norris, Qing Han, Sun Hee Kim, Maria V. Sergeeva, Laurie A. LeBrun, Mcguire Helen
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
A novel series of HCV NS5B polymerase inhibitors comprising 1,1-dioxoisothiazoles and benzo[b]thiophene-1,1-dioxides were designed, synthesized, and evaluated. SAR studies guided by structure-based design led to the identification of a number of pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5730429014fd2b04b0b30434d8cf5a
https://pubmed.ncbi.nlm.nih.gov/18554907
https://pubmed.ncbi.nlm.nih.gov/18554907
Autor:
David Archer Ellis, Valentina Molteni
Publikováno v:
ChemInform. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58f47510f4cbc0dee7acabd3afe1330a
https://doi.org/10.1002/chin.200540291
https://doi.org/10.1002/chin.200540291