Zobrazeno 1 - 10
of 100
pro vyhledávání: '"David Anz"'
Autor:
Ying Wang, Carolin Ertl, Christina Schmitt, Linda Hammann, Rafaela Kramer, Ulrich Grabmaier, Florian Schöberl, David Anz, Ignazio Piseddu, Giulia Pesch, Julio Vera, Waltraud Froehlich, Ludwig Weckbach, Dirk Tomsitz, Carmen Loquai, Lisa Zimmer, Johanna Mangana, Reinhard Dummer, Ralf Gutzmer, Kai-Christian Klespe, Henner Stege, Frank Meiss, Kai-Martin Thoms, Patrick Terheyden, Paul J. Bröckelmann, Douglas B. Johnson, Lars E. French, Lucie Heinzerling
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundImmune checkpoint inhibitor (ICI)-induced myocarditis is a rare immune-related adverse event (irAE) with a fatality rate of 40%–46%. However, irMyocarditis can be asymptomatic. Thus, improved monitoring, detection and therapy are needed.
Externí odkaz:
https://doaj.org/article/0d24ababd2e842d890215bef5ee1389e
Autor:
Florian Märkl, Christoph Schultheiß, Murtaza Ali, Shih-Shih Chen, Marina Zintchenko, Lukas Egli, Juliane Mietz, Obinna Chijioke, Lisa Paschold, Sebastijan Spajic, Anne Holtermann, Janina Dörr, Sophia Stock, Andreas Zingg, Heinz Läubli, Ignazio Piseddu, David Anz, Marcus Dühren-von Minden, Tianjiao Zhang, Thomas Nerreter, Michael Hudecek, Susana Minguet, Nicholas Chiorazzi, Sebastian Kobold, Mascha Binder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The concept of precision cell therapy targeting tumor-specific mutations is appealing but requires surface-exposed neoepitopes, which is a rarity in cancer. B cell receptors (BCR) of mature lymphoid malignancies are exceptional in that they
Externí odkaz:
https://doaj.org/article/f556d70ecba646069501e54817da7995
Autor:
Tilman L. B. Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J. Jacobi, Cornelius M. Funk, Florian H. Geyer, Jing Li, Ignazio Piseddu, Bruno L. Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G. P. Grünewald, Maximilian M. L. Knott
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Despite their exquisite specificity, these d
Externí odkaz:
https://doaj.org/article/78ef503cfc5a4dd49687b1bc7f0319d1
Autor:
Martin G. Scherm, Rebecca C. Wyatt, Isabelle Serr, David Anz, Sarah J. Richardson, Carolin Daniel
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101565- (2022)
Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells. There are multiple
Externí odkaz:
https://doaj.org/article/d03c0f094db1468697639ac277d719fa
Autor:
Benjamin Kuehnemuth, Ignazio Piseddu, Gabriela M. Wiedemann, Michael Lauseker, Christina Kuhn, Simone Hofmann, Elisa Schmoeckel, Stefan Endres, Doris Mayr, Udo Jeschke, David Anz
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-6 (2018)
Abstract Background Regulatory T cells (Treg) suppress cytotoxic T cell anti-tumoral immune responses and thereby promote tumor progression. Prevention of intratumoral Treg accumulation by inhibition of their migration to the tumor microenvironment i
Externí odkaz:
https://doaj.org/article/cf2fc812caab4ec68ce98d88a6d623d2
Autor:
Sarah Meister, Laura Hahn, Susanne Beyer, Mareike Mannewitz, Carolin Perleberg, Konstantin Schnell, David Anz, Stefanie Corradini, Elisa Schmoeckel, Doris Mayr, Uwe Hasbargen, Alaleh Zati Zehni, Sven Mahner, Udo Jeschke, Thomas Kolben
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1880 (2022)
There are several open questions to be answered regarding the pathophysiology of the development of preeclampsia (PE). Numerous factors are involved in its genesis, such as defective placentation, vascular impairment, and an altered immune response.
Externí odkaz:
https://doaj.org/article/a463d70efcba4595a306854619dfedd9
Autor:
Antonis Makrigiannakis, Udo Jeschke, Klaus Friese, Darius Dian, Iordanis Navrozoglou, Julia Knabl, David Anz, Sabine Heublein, Birgit Bayer, Thomas Vrekoussis, Sabine Guenther
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 7, Pp 9069-9080 (2012)
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samp
Externí odkaz:
https://doaj.org/article/5509887e45744b66b39f045f4ad1cc17
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111757 (2014)
Tumor infiltrating CD4+CD25+FoxP3+ regulatory immune cells (Treg) have been associated with impaired anti-tumor immune response and unfavorable prognosis for patients affected by ovarian carcinoma, whereas CD8+ T-cells have been found to positively i
Externí odkaz:
https://doaj.org/article/c066e64ffca848e6b9af06776d1969d9
Autor:
Carole Bourquin, Stefan Endres, David Anz, Moritz Rapp, Nadja Sandholzer, Philipp Bittner, Georg Wedekind, Daniel Nörenberg, Helen Bauer, Christine Zoglmeier
Purpose: The Toll-like receptor (TLR) 9 ligand CpG has been used successfully for the immunotherapy of cancer. Chronic CpG application in tumor-free hosts leads, however, to the expansion of myeloid-derived suppressor cells (MDSC), which can cause T-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e835adb5cafb3d9227a229ebc58ec38
https://doi.org/10.1158/1078-0432.c.6519083.v1
https://doi.org/10.1158/1078-0432.c.6519083.v1
Autor:
Carole Bourquin, Stefan Endres, David Anz, Moritz Rapp, Nadja Sandholzer, Philipp Bittner, Georg Wedekind, Daniel Nörenberg, Helen Bauer, Christine Zoglmeier
Related CCR Translation from CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e72dffbcafbe73a2f350fd312714423
https://doi.org/10.1158/1078-0432.22442318.v1
https://doi.org/10.1158/1078-0432.22442318.v1