Zobrazeno 1 - 10
of 275
pro vyhledávání: '"David Amar"'
Autor:
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain po
Externí odkaz:
https://doaj.org/article/d8b8fe0a0e6941c7a811944dff8fc5cc
Autor:
Victoria N. Parikh, Alexander G. Ioannidis, David Jimenez-Morales, John E. Gorzynski, Hannah N. De Jong, Xiran Liu, Jonasel Roque, Victoria P. Cepeda-Espinoza, Kazutoyo Osoegawa, Chris Hughes, Shirley C. Sutton, Nathan Youlton, Ruchi Joshi, David Amar, Yosuke Tanigawa, Douglas Russo, Justin Wong, Jessie T. Lauzon, Jacob Edelson, Daniel Mas Montserrat, Yongchan Kwon, Simone Rubinacci, Olivier Delaneau, Lorenzo Cappello, Jaehee Kim, Massa J. Shoura, Archana N. Raja, Nathaniel Watson, Nathan Hammond, Elizabeth Spiteri, Kalyan C. Mallempati, Gonzalo Montero-Martín, Jeffrey Christle, Jennifer Kim, Anna Kirillova, Kinya Seo, Yong Huang, Chunli Zhao, Sonia Moreno-Grau, Steven G. Hershman, Karen P. Dalton, Jimmy Zhen, Jack Kamm, Karan D. Bhatt, Alina Isakova, Maurizio Morri, Thanmayi Ranganath, Catherine A. Blish, Angela J. Rogers, Kari Nadeau, Samuel Yang, Andra Blomkalns, Ruth O’Hara, Norma F. Neff, Christopher DeBoever, Sándor Szalma, Matthew T. Wheeler, Christian M. Gates, Kyle Farh, Gary P. Schroth, Phil Febbo, Francis deSouza, Omar E. Cornejo, Marcelo Fernandez-Vina, Amy Kistler, Julia A. Palacios, Benjamin A. Pinsky, Carlos D. Bustamante, Manuel A. Rivas, Euan A. Ashley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
There is a genetic component to the risk of severe COVID-19, but the genetic effects are difficult to separate from social constructs that covary with genetic ancestry. To address this, the authors identify determinants of COVID-19 severity using adm
Externí odkaz:
https://doaj.org/article/10002eca5587461185e42393a7dc16a5
Autor:
David Amar, Malene E. Lindholm, Jessica Norrbom, Matthew T. Wheeler, Manuel A. Rivas, Euan A. Ashley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Regular exercise promotes overall health and prevents non-communicable diseases, but the adaptation mechanisms are unclear. Here, the authors perform a meta-analysis to reveal time-specific patterns of the acute and long-term exercise response in hum
Externí odkaz:
https://doaj.org/article/23884a9bb5dd4087b4ca76abb19bc960
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analy
Externí odkaz:
https://doaj.org/article/2de5d6dbd2ae49f294dc1e672035ea20
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Recent sequencing technologies enable joint quantification of promoters and their enhancer regions, allowing inference of enhancer–promoter links. We show that current enhancer–promoter inference methods produce a high rate of false posi
Externí odkaz:
https://doaj.org/article/35bdbcbd72d44ba386b2937bfb76819c
Autor:
Emmi Tikkanen, Stefan Gustafsson, David Amar, Anna Shcherbina, Daryl Waggott, Euan A. Ashley, Erik Ingelsson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology with and causal effects of muscular strength on several health indicators. In our di
Externí odkaz:
https://doaj.org/article/3bf66095c61b4c51a9330c0ef93d28da
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0219728 (2019)
BackgroundThe 2017 guidelines of the American College of Cardiology and the American Heart Association propose substantial changes to hypertension management. The guidelines lower the blood pressure threshold defining hypertension and promote more ag
Externí odkaz:
https://doaj.org/article/92bbf2d3c111400aa6ba7e4f28d6092a
Autor:
Arthur Zwaenepoel, Tim Diels, David Amar, Thomas Van Parys, Ron Shamir, Yves Van de Peer, Oren Tzfadia
Publikováno v:
Frontiers in Plant Science, Vol 9 (2018)
Recent times have seen an enormous growth of “omics” data, of which high-throughput gene expression data are arguably the most important from a functional perspective. Despite huge improvements in computational techniques for the functional class
Externí odkaz:
https://doaj.org/article/33879cd33734457cb5647928ce4b6f6e
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 10, p e1005807 (2017)
The adaptation of the CRISPR-Cas9 system as a genome editing technique has generated much excitement in recent years owing to its ability to manipulate targeted genes and genomic regions that are complementary to a programmed single guide RNA (sgRNA)
Externí odkaz:
https://doaj.org/article/6589b9896e8c45599db19bc5212f70a6
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 8, p e1005700 (2017)
In almost every field in genomics, large-scale biomedical datasets are used to report associations. Extracting associations that recur across multiple studies while controlling the false discovery rate is a fundamental challenge. Here, we propose a n
Externí odkaz:
https://doaj.org/article/72a5513008b6447fa64f77dc02812519