Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David Alvarez‐Carbonell"'
Autor:
Harpreet Kaur, Paige Minchella, David Alvarez-Carbonell, Neeraja Purandare, Vijay K. Nagampalli, Daniel Blankenberg, Todd Hulgan, Mariana Gerschenson, Jonathan Karn, Siddhesh Aras, Asha R. Kallianpur
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12242 (2023)
HIV-associated cognitive dysfunction during combination antiretroviral therapy (cART) involves mitochondrial dysfunction, but the impact of contemporary cART on chronic metabolic changes in the brain and in latent HIV infection is unclear. We interro
Externí odkaz:
https://doaj.org/article/2c92077cfce847e5aeeb5e45b0b98d7d
Autor:
Iart Luca Shytaj, Francesco Andrea Procopio, Mohammad Tarek, Irene Carlon‐Andres, Hsin‐Yao Tang, Aaron R Goldman, MohamedHusen Munshi, Virender Kumar Pal, Mattia Forcato, Sheetal Sreeram, Konstantin Leskov, Fengchun Ye, Bojana Lucic, Nicolly Cruz, Lishomwa C Ndhlovu, Silvio Bicciato, Sergi Padilla‐Parra, Ricardo Sobhie Diaz, Amit Singh, Marina Lusic, Jonathan Karn, David Alvarez‐Carbonell, Andrea Savarino
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-20 (2021)
Abstract HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a determinant of susceptibility to HIV‐1 infection, but i
Externí odkaz:
https://doaj.org/article/c1e843aa09bd42f190c50b143e7746de
Autor:
Fengchun Ye, David Alvarez-Carbonell, Kien Nguyen, Konstantin Leskov, Yoelvis Garcia-Mesa, Sheetal Sreeram, Saba Valadkhan, Jonathan Karn
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010110 (2022)
Human immune deficiency virus (HIV) infection in the brain leads to chronic neuroinflammation due to the production of pro-inflammatory cytokines, which in turn promotes HIV transcription in infected microglial cells. However, powerful counteracting
Externí odkaz:
https://doaj.org/article/c21c6998b8db4f439fdeda3ee5597b07
Autor:
David Alvarez-Carbonell, Fengchun Ye, Nirmala Ramanath, Yoelvis Garcia-Mesa, Pamela E Knapp, Kurt F Hauser, Jonathan Karn
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008249 (2019)
Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders (HAND) are found in nearly one-third of patients. Using a cellular co-culture system including neurons and human microglia infected with HIV (hμglia/HIV), we inv
Externí odkaz:
https://doaj.org/article/32e63d33c82b4fd6bffef404aed6f320
Autor:
Vladimir M. Milenkovic, Dounia Slim, Stefanie Bader, Victoria Koch, Elena-Sofia Heinl, David Alvarez-Carbonell, Caroline Nothdurfter, Rainer Rupprecht, Christian H. Wetzel
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3359 (2019)
The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. It has been implicated in the regulation of various cellular processes including oxidative stress, prolifer
Externí odkaz:
https://doaj.org/article/9923855470eb40629f22cbe7ed1db5f3
Autor:
Fengchun Ye, S. Sreeram, Y. Garcia-Mesa, David Alvarez-Carbonell, Konstantin Leskov, Saba Valadkhan, K. Nguyen, Jonathan Karn
Human immune deficiency virus (HIV) infection of microglial cells in the brain leads to chronic neuroinflammation, which is antecedent to the development of HIV-associated neurocognitive disorders (HAND) in the majority of patients. Productively HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa31e724c7c9a0c120d9ac0b03ef0779
https://doi.org/10.1101/2021.11.16.468784
https://doi.org/10.1101/2021.11.16.468784
Autor:
Fengchun Ye, David Alvarez-Carbonell, Kien Nguyen, Konstantin Leskov, Yoelvis Garcia-Mesa, Sheetal Sreeram, Saba Valadkhan, Jonathan Karn
Publikováno v:
PLoS pathogens. 18(7)
Human immune deficiency virus (HIV) infection in the brain leads to chronic neuroinflammation due to the production of pro-inflammatory cytokines, which in turn promotes HIV transcription in infected microglial cells. However, powerful counteracting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9def5f1d2efda9e84d58f1bee3f98dbe
https://pubmed.ncbi.nlm.nih.gov/35797416
https://pubmed.ncbi.nlm.nih.gov/35797416
Autor:
Kamel Khalili, Purnima V. Gupta, Sneham Tiwari, Ajeet Kaushik, Adriana Yndart, Asahi Tomitaka, Venkata Subba Rao Atluri, Rahul Dev Jayant, Madhavan Nair, David Alvarez-Carbonell
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency virus (HIV) genome but the delivery of this therapeutic cargo to the brain remains as a challenge. In this research, for the first time, we demonstrated magnetically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa35e78769c8ba2984935b43b3afe1b
http://link.springer.com/article/10.1038/s41598-019-40222-4
http://link.springer.com/article/10.1038/s41598-019-40222-4
Autor:
Aaron R. Goldman, Fengchun Ye, Andrea Savarino, Konstantin Leskov, Iart Luca Shytaj, Mattia Forcato, David Alvarez-Carbonell, Bojana Lucic, Irene Carlon-Andres, Amit Singh, Marina Lusic, Ricardo Sobhie Diaz, Silvio Bicciato, MohamedHusen Munshi, Nicolly Cruz, Mohammad Tarek, Hsin-Yao Tang, Francesco A. Procopio, Sergi Padilla-Parra
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a determinant of susceptibility to HIV-1 infection, but its role in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242cb63dffab6cb78b5ef9e697b8caee
https://doi.org/10.1101/2020.12.30.424810
https://doi.org/10.1101/2020.12.30.424810
Autor:
Guanguan Li, Leggy A. Arnold, Ian W Luecke, Douglas C. Stafford, Taylor M Wilcox, Michael M Poe, Yeunus Mian, David Alvarez-Carbonell, Brandon N Mikulsky, Alexander S. Kehoe, Dylan A Hoffman, Amanda N. Nieman, James M. Cook, Nicolas M Zahn
Publikováno v:
ACS Chem Neurosci
The goal of this research is the identification of new treatments for neuropathic pain. We characterized the GABAergic system of immortalized mouse and human microglia using electrophysiology and qRT-PCR. Cells from both species exhibited membrane cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c0679da8505aced46d71357fc44c3a
https://pubmed.ncbi.nlm.nih.gov/32511908
https://pubmed.ncbi.nlm.nih.gov/32511908