Zobrazeno 1 - 10
of 50
pro vyhledávání: '"David Allan Butterfield"'
Autor:
David Allan Butterfield, Maria Favia, Iolanda Spera, Annalisa Campanella, Martina Lanza, Alessandra Castegna
Publikováno v:
Molecules, Vol 27, Iss 3, p 951 (2022)
Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and parti
Externí odkaz:
https://doaj.org/article/18ecd021ea5d495583e2b04dc21e1ee4
Autor:
Laura Buizza, Giovanna Cenini, Cristina Lanni, Giulia Ferrari-Toninelli, Chiara Prandelli, Stefano Govoni, Erica Buoso, Marco Racchi, Maria Barcikowska, Maria Styczynska, Aleksandra Szybinska, David Allan Butterfield, Maurizio Memo, Daniela Uberti
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29789 (2012)
In order to study oxidative stress in peripheral cells of Alzheimer's disease (AD) patients, immortalized lymphocytes derived from two peculiar cohorts of patients, referring to early onset AD (EOSAD) and subjects harboured AD related mutation (ADmut
Externí odkaz:
https://doaj.org/article/860c213592a84a718237a1964f1938fe
Autor:
Roberto Gedaly, David Allan Butterfield, Pratheeshkumar Poyil, Mihail I. Mitov, Francesc Marti, Valery Vilchez, Luis F. Acosta, Lilia Turcios
Publikováno v:
Digestive and Liver Disease. 49:697-704
Treatment of advanced hepatocellular carcinoma (HCC) remains a challenge due to the high tumor heterogeneity. In the present study, we aim to evaluate the impact of the β-catenin inhibitor, FH535, alone or in combination with the Ras/Raf/MAPK inhibi
Autor:
Roberto Gedaly, Cristin Coquillard, David Allan Butterfield, Virgilius Cornea, Valery Vilchez, Lilia Turcios, Mihail I. Mitov, Francesc Marti, J. Brandon
Publikováno v:
Transplant International. 30
The PI3K/mTOR signaling cascade is fundamental in T-cell activation and fate decisions. We showed the distinct regulation of PI3K/mTOR in regulatory and effector T-cells and proposed the potential therapeutic benefit of targeting this pathway to cont
Autor:
J. Cai, Sumitra Miriyala, Rukhsana Sultana, Ines Batinic-Haberle, Mary Vore, Lu Miao, Subbarao Bondada, Yanming Zhao, Jon B. Klein, D.K. St. Clair, David Allan Butterfield, Mihail I. Mitov, David M. Schnell, Sanjit K. Dhar
Publikováno v:
Free Radical Biology and Medicine. 72:55-65
Doxorubicin (DOX), one of the most effective anticancer drugs, is known to generate progressive cardiac damage, which is due, in part, to DOX-induced reactive oxygen species (ROS). The elevated ROS often induce oxidative protein modifications that re
Autor:
Lynn Ulatowski, Robert S. Parker, Govind Warrier, David Allan Butterfield, Danny Manor, Rukhsana Sultana
Publikováno v:
Neuroscience. 260:120-129
α-Tocopherol (vitamin E) is an essential dietary antioxidant with important neuroprotective functions. α-Tocopherol deficiency manifests primarily in neurological pathologies, notably cerebellar dysfunctions such as spinocerebellar ataxia. To study
Publikováno v:
Expert Opinion on Investigational Drugs. 20:1243-1261
Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by severe cognitive impairment, inability to perform activities of daily living and mood changes. Acetylcholinesterase inhibitors or NMDA glutamate receptor antagonists
Autor:
Vittorio Calabrese, Carolin Cornelius, F. Di Domenico, Marzia Perluigi, David Allan Butterfield
Publikováno v:
Neurochemical Research. 35:2184-2192
Aging is characterized by a gradual and continuous loss of physiological functions and responses particularly marked in the central nervous system. Reactive oxygen species (ROS) can react with all major biological macromolecules such as carbohydrates
Autor:
I. Doubinskaia, Ines Batinic-Haberle, Wanida Ittarat, D.K. St. Clair, David Allan Butterfield, Yumin Chen, Hafiz Mohmmad Abdul, Jitbanjong Tangpong, Pradoldej Sompol
Publikováno v:
Neuroscience. 153:120-130
Alzheimer's disease (AD) is associated with beta-amyloid accumulation, oxidative stress and mitochondrial dysfunction. However, the effects of genetic mutation of AD on oxidative status and mitochondrial manganese superoxide dismutase (MnSOD) product
Autor:
Rukhsana Sultana, David Allan Butterfield, A. M. Giuffrida Stella, Menotti Calvani, Vittorio Calabrese, Giovanni Scapagnini, C Colombrita
Publikováno v:
Antioxidants & redox signalling 8(3-4 (2006): 404–416.
info:cnr-pdr/source/autori:Calabrese V, Colombrita C, Sultana R, Scapagnini G, Calvani M, Butterfield DA, Stella AM./titolo:Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function./doi:/rivista:Antioxidants & redox signalling/anno:2006/pagina_da:404/pagina_a:416/intervallo_pagine:404–416/volume:8(3-4
info:cnr-pdr/source/autori:Calabrese V, Colombrita C, Sultana R, Scapagnini G, Calvani M, Butterfield DA, Stella AM./titolo:Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function./doi:/rivista:Antioxidants & redox signalling/anno:2006/pagina_da:404/pagina_a:416/intervallo_pagine:404–416/volume:8(3-4
There is significant evidence to show that aging is characterized by a stochastic accumulation of molecular damage and by a progressive failure of maintenance and repair processes. Protective mechanisms exist in the brain which are controlled by vita