Zobrazeno 1 - 10
of 27
pro vyhledávání: '"David Alkalay"'
Autor:
Eran Gilat, Ben Avi Weissman, David Alkalay, Hagar Sonego, Lily Raveh, Rachel Brandeis, Ishai Rabinovitz, Giora Cohen
Publikováno v:
Annals of the New York Academy of Sciences. 1025:584-589
Several drugs of abuse are known to produce an array of deleterious effects, including alterations in neuronal circuitry and, ultimately, neuronal degeneration. For instance, methamphetamine was shown to induce substantial nigrostriatal dopaminergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ef10aea1028ebadbb5306bc00fc68a
https://doi.org/10.1196/annals.1316.072
https://doi.org/10.1196/annals.1316.072
Publikováno v:
Biological Mass Spectrometry. 20:26-30
An analytical method has been developed for the simultaneous determination of a novel orally active angiotensin-converting enzyme inhibitor (CGS 16617) and a stable isotope-labeled analog. Both compounds are isolated from human plasma using an ion-ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f0971027f1ecf86b75a4ae23d4900e
https://doi.org/10.1002/bms.1200200107
https://doi.org/10.1002/bms.1200200107
Autor:
Eran Gilat, Ben Avi Weissman, Lily Raveh, Hagar Sonego, Giora Cohen, Rachel Brandeis, David Alkalay, Ishai Rabinovitz
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 75(1)
Soman, a powerful inhibitor of acetylcholinesterase, causes an array of toxic effects in the central nervous system including convulsions, learning and memory impairments, and, ultimately, death. We report on the protection afforded by postexposure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3085242fc15aa0d55988ebdd8ed4c694
https://pubmed.ncbi.nlm.nih.gov/12832655
https://pubmed.ncbi.nlm.nih.gov/12832655
Autor:
Ben Avi Weissman, Hagar Sonego, Giora Cohen, Ishai Rabinovitz, Lily Raveh, David Alkalay, Rachel Brandeis
Publikováno v:
Neurotoxicology. 23(1)
Exposure to soman, a toxic organophosphate nerve agent, causes severe adverse effects and long term changes in the peripheral and central nervous systems. The goal of this study was to evaluate the ability of prophylactic treatments to block the dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca25ef43461122e70507150a56fe6d34
https://pubmed.ncbi.nlm.nih.gov/12164550
https://pubmed.ncbi.nlm.nih.gov/12164550
Autor:
Z. Tashma, Giora Cohen, S. Givoni, E. Grauer, Lily Raveh, David Alkalay, M. Alcalay, Joseph Kapon, H. Liani
Publikováno v:
Journal of applied toxicology : JAT. 21
Benzodiazepines, mainly diazepam, are commonly used as anticonvulsants in the treatment of organophosphate casualties. Although very effective, diazepam usually is not used in prophylactic treatments because of its adverse effects on task performance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bd3e404968269658cac8246624c4ab
https://pubmed.ncbi.nlm.nih.gov/11920931
https://pubmed.ncbi.nlm.nih.gov/11920931
Publikováno v:
Humanexperimental toxicology. 14(3)
Sarin, a highly toxic cholinesterase (ChE) inhibitor, administered at near 1 LD50 dose causes severe signs of toxic cholinergic hyperactivity in both the peripheral and central nervous systems (CNS). The present study evaluated acute and long-term ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debd4a1668600675da24aad38763b82c
https://pubmed.ncbi.nlm.nih.gov/7779455
https://pubmed.ncbi.nlm.nih.gov/7779455
Publikováno v:
Biological Mass Spectrometry. 6:200-204
A procedure is described which permits the simultaneous determination of imipramine and desipramine or clomipramine and N-desmethylclomipramine in serum or plasma for concentrations in the range of 1-200 ng ml-1. Detection limits of 0.2 ng ml-1 for i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8b05b8d53a45488b224541cb192aed
https://doi.org/10.1002/bms.1200060506
https://doi.org/10.1002/bms.1200060506
Autor:
David Alkalay, Joseph Volk, Lakshmi Khemani, Anne LeSher, Stephen Carlsen, M. Fred Bartlett, William E. Wagner
Publikováno v:
Clinical Pharmacology and Therapeutics. 27:697-703
Six male subjects received simultaneously single 50-mg oral doses of a maprotiline hydrochloride tablet and a trideuterated maprotiline hydrochloride aqueous solution. No side effects or other problems were encountered. The blood levels of unlabeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84440fe1524ae3f79a58e1aaf6d5af53
https://doi.org/10.1038/clpt.1980.99
https://doi.org/10.1038/clpt.1980.99
Publikováno v:
Analytical Letters. 15:1493-1503
A procedure is described which permits the determination of maprotiline in biological fluids for concentrations in the range of 10 to 1000 ng/ml. It relies on the use of N-desmethylclomipramine as internal standard, on derivatization of the secondary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e2ac1c1a510f6c12ff8e01bbe0b8b3
https://doi.org/10.1080/00032718208065140
https://doi.org/10.1080/00032718208065140
Publikováno v:
Biological Mass Spectrometry. 6:435-438
A procedure is described which permits the determination of maprotiline in biological fluids at concentrations ranging from 0.5 to 150 ng ml-1. It relies on the use of N-desmethylclomipramine or isotope labeled maprotiline as the internal standard, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae24a3e5bc92aa2469f04ee0f6a3696
https://doi.org/10.1002/bms.1200061006
https://doi.org/10.1002/bms.1200061006