Zobrazeno 1 - 10
of 40
pro vyhledávání: '"David Aguinaga"'
Autor:
Rafael Rivas-Santisteban, Iu Raïch, David Aguinaga, Carlos A. Saura, Rafael Franco, Gemma Navarro
Publikováno v:
Cells, Vol 12, Iss 2, p 283 (2023)
Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer’s disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD. We hypothesized that PrPC modulates NMDA signal
Externí odkaz:
https://doaj.org/article/e07c90400a1a4638b70861446deb8c03
Autor:
Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick, Rafael Franco
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract Background G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (A1-A2AHet), and th
Externí odkaz:
https://doaj.org/article/d4dd4c7d0655450796391030f760eb1d
Autor:
Rafael Franco, David Aguinaga, Irene Reyes, Enric I. Canela, Jaume Lillo, Airi Tarutani, Masato Hasegawa, Anna del Ser-Badia, José A. del Rio, Michael R. Kreutz, Carlos A. Saura, Gemma Navarro
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
N-methyl-D-aspartate receptors (NMDARs) respond to glutamate to allow the influx of calcium ions and the signaling to the mitogen-activated protein kinase (MAPK) cascade. Both MAPK- and Ca2+-mediated events are important for both neurotransmission an
Externí odkaz:
https://doaj.org/article/3ca679e6926743efaef20a56da8d2239
Autor:
Edgar Angelats, Marta Requesens, David Aguinaga, Michael R. Kreutz, Rafael Franco, Gemma Navarro
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Endocannabinoids are important players in neural development and function. They act via receptors, whose activation inhibits cAMP production. The aim of the paper was to look for calcium- and cAMP-signaling cross-talk mediated by cannabinoid CB1 rece
Externí odkaz:
https://doaj.org/article/89ef023f68ed415f91dbc36ebc93bb16
Autor:
David Aguinaga, Mireia Medrano, Ignacio Vega-Quiroga, Katia Gysling, Enric I. Canela, Gemma Navarro, Rafael Franco
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Sigma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, a key neurotransmitter in CNS motor con
Externí odkaz:
https://doaj.org/article/25499f4370fe4d03a1a8aa829777a829
Autor:
Gemma Navarro, Estefania Moreno, Jordi Bonaventura, Marc Brugarolas, Daniel Farré, David Aguinaga, Josefa Mallol, Antoni Cortés, Vicent Casadó, Carmen Lluís, Sergi Ferre, Rafael Franco, Enric Canela, Peter J McCormick
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61245 (2013)
Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopa
Externí odkaz:
https://doaj.org/article/9ed43522cb714fb4bf2d9388cee44c68
Autor:
Baker, Nicola, Glover, Lucy, Munday, Jane C., Andrés, David Aguinaga, Barrett, Michael P., de Koning, Harry P., Horn, David
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2012 Jul 01. 109(27), 10996-11001.
Externí odkaz:
https://www.jstor.org/stable/41601718
Autor:
Gemma Navarro, Irene Reyes-Resina, Mireia Casanovas, David Aguinaga, Rafael Franco, Rafael Rivas-Santisteban
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Addiction and eating disorders involve brain reward circuits. Binge eating predisposes to addictive behavior, while the cessation of exposure to drugs of abuse leads to reward activities, including intake of tasty foods. Cocaine use is associated wit
Autor:
Carlos A. Saura, Verónica Sánchez de Medina, Dasiel O. Borroto-Escuela, Rafael Franco, Kjell Fuxe, Iu Raïch, Carlos Ferreiro-Vera, Gemma Navarro, Enric I. Canela, Anna Del Ser-Badia, Jasmina Jiménez, David Aguinaga, Irene Reyes-Resina, Alejandro Lillo
Publikováno v:
Glia. 67:2410-2423
Neuroprotective M2-skewed microglia appear as promising to alter the course of neurodegenerative diseases and G protein-coupled receptors (GPCRs) are potential targets to achieve such microglial polarization. A common feature of adenosine A2A (A2A R)
Autor:
Mireia Medrano, Rafael Franco, Alejandro Lillo, Josefa Mallol, Gemma Navarro, David Aguinaga, Jasmina Jiménez, Katia Gysling, Ignacio Vega-Quiroga, Mireia Casanovas, Enric I. Canela
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Stress is one of the factors underlying drug seeking behavior that often goes in parallel with loss of appetite. We here demonstrate that orexin 1 receptors (OX1R) may form complexes with the corticotropin releasing factor CRF2 receptor. Two specific