Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David Adrian Ewald"'
Autor:
Stefan Eirefelt, Martin Stahlhut, Naila Svitacheva, Martin A. Carnerup, Joel Mauricio Correa Da Rosa, David Adrian Ewald, Troels T. Marstrand, Mikkel Krogh-Madsen, Georg Dünstl, Kevin Neil Dack, Anna Ollerstam, Hanne Norsgaard
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Glucocorticoids (GCs) are commonly used topical treatments for skin diseases but are associated with both local and systemic side effects. In this study, we describe a selective non-steroidal glucocorticoid receptor (GR) agonist for topical
Externí odkaz:
https://doaj.org/article/cfd4a2be093d473793d9d6101bfebe75
Autor:
Tu Hu, Tanja Todberg, David Adrian Ewald, Ilka Hoof, Joel Correa da Rosa, Lone Skov, Thomas Litman
Publikováno v:
Hu, T, Todberg, T, Ewald, D A, Hoof, I, Correa da Rosa, J, Skov, L & Litman, T 2023, ' Assessment of Spatial and Temporal Variation in the Skin Transcriptome of Atopic Dermatitis by Use of 1.5 mm Minipunch Biopsies ', Journal of Investigative Dermatology, vol. 143, no. 4, pp. 612-620.e6 . https://doi.org/10.1016/j.jid.2022.10.004
Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by a heterogeneous and fluctuating disease course. To obtain a detailed molecular understanding of both the temporal and spatial variation in AD, we conducted a longitudinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1289674a39aa533b46bb6c4fa94db2
https://doi.org/10.1016/j.jid.2022.10.004
https://doi.org/10.1016/j.jid.2022.10.004
Autor:
Tu Hu, Tanja Todberg, Daniel Andersen, Niels Banhos Danneskiold-Samsøe, Sofie Boesgaard Neestrup Hansen, Karsten Kristiansen, David Adrian Ewald, Susanne Brix, Joel Correa da Rosa, Ilka Hoof, Lone Skov, Thomas Litman
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6140
Hu, T, Todberg, T, Andersen, D, Danneskiold-Samsøe, N B, Hansen, S B N, Kristiansen, K, Ewald, D A, Brix, S, da Rosa, J C, Hoof, I, Skov, L & Litman, T 2022, ' Profiling the Atopic Dermatitis Epidermal Transcriptome by Tape Stripping and BRB-seq ', International Journal of Molecular Sciences, vol. 23, no. 11, 6140 . https://doi.org/10.3390/ijms23116140
Hu, T, Todberg, T, Andersen, D, Danneskiold-Samsøe, N B, Hansen, S B N, Kristiansen, K, Ewald, D A, Brix, S, Rosa, J C D, Hoof, I, Skov, L & Litman, T 2022, ' Profiling the Atopic Dermatitis Epidermal Transcriptome by Tape Stripping and BRB-seq ', International Journal of Molecular Sciences, vol. 23, no. 11, 6140 . https://doi.org/10.3390/ijms23116140
Hu, T, Todberg, T, Andersen, D, Danneskiold-Samsøe, N B, Hansen, S B N, Kristiansen, K, Ewald, D A, Brix, S, da Rosa, J C, Hoof, I, Skov, L & Litman, T 2022, ' Profiling the Atopic Dermatitis Epidermal Transcriptome by Tape Stripping and BRB-seq ', International Journal of Molecular Sciences, vol. 23, no. 11, 6140 . https://doi.org/10.3390/ijms23116140
Hu, T, Todberg, T, Andersen, D, Danneskiold-Samsøe, N B, Hansen, S B N, Kristiansen, K, Ewald, D A, Brix, S, Rosa, J C D, Hoof, I, Skov, L & Litman, T 2022, ' Profiling the Atopic Dermatitis Epidermal Transcriptome by Tape Stripping and BRB-seq ', International Journal of Molecular Sciences, vol. 23, no. 11, 6140 . https://doi.org/10.3390/ijms23116140
Tape stripping is a non-invasive skin sampling technique, which has recently gained use for the study of the transcriptome of atopic dermatitis (AD), a common inflammatory skin disorder characterized by a defective epidermal barrier and perturbated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec346b14f78b1f04fd1d13f4d499b33
https://pubmed.ncbi.nlm.nih.gov/35682818
https://pubmed.ncbi.nlm.nih.gov/35682818
Autor:
Emma Guttman-Yassky, David Adrian Ewald, Benjamin Ungar, James G. Krueger, Hitokazu Esaki, Mariya Rozenblit, Xiangyu Peng, Thomas Litman, Mayte Suárez-Fariñas, Hiroshi Mitsui, Xiuzhong Zheng, Hui Xu, Yeriel Estrada
Background The molecular signature of atopic dermatitis (AD) lesions is associated with TH2 and TH22 activation and epidermal alterations. However, the epidermal and dermal AD transcriptomes and their respective contributions to abnormalities in resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad73fd8f94741ca67005dbf5f35ec0c
http://hdl.handle.net/2324/4495983
http://hdl.handle.net/2324/4495983
Autor:
S D Pilger, Xuan Li, M A X Tollenaere, James G. Krueger, Josephine Hebsgaard, David Adrian Ewald, Sandra Garcet, Hanne Norsgaard, M Bertelsen, Paola Lovato, M L Tiirikainen
Publikováno v:
The British Journal of Dermatology
Summary Background The interleukin (IL)‐23/IL‐17 immune axis is of central importance in psoriasis. However, the impact of IL‐17 family cytokines other than IL‐17A in psoriasis has not been fully established. Objectives To elucidate the contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba202ebce2fcf1c83b713fe01d67e7e
https://pubmed.ncbi.nlm.nih.gov/34259344
https://pubmed.ncbi.nlm.nih.gov/34259344
Publikováno v:
Dermatology and Therapy
Introduction T-helper 17 (Th17) cytokines play a key role in the pathophysiology of psoriasis by driving inflammatory responses that lead to epidermal alterations. Markers of epidermal differentiation, including the proteins loricrin (LOR), filaggrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915de6d8e09a64272deb741c7fc7081b
https://pubmed.ncbi.nlm.nih.gov/33458806
https://pubmed.ncbi.nlm.nih.gov/33458806
Autor:
Chris B. Russell, Mayte Suárez-Fariñas, Lewis Tomalin, Sandra Garcet, Hanne Norsgaard, David Adrian Ewald, James G. Krueger, Ajay Nirula, Paul Klekotka
Publikováno v:
The Journal of allergy and clinical immunology. 145(3)
Background IL-17 antagonists induce impressive clinical benefits in psoriasis, but it is unknown to what extent cellular and molecular psoriasis characteristics are suppressed by a clinically relevant dose/schedule of any IL-17-receptor antagonist. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60815e3fc00f42b8521343f11dabb9d
https://pubmed.ncbi.nlm.nih.gov/31883845
https://pubmed.ncbi.nlm.nih.gov/31883845
Autor:
Maria Louise Leth, Signe Schultz Pedersen, Maher Abou Hachem, Morten Ejby, Finn Lillelund Aachmann, David Adrian Ewald, Christopher T. Workman, Martin Iain Bahl, Bjørge Westereng, Claus Sternberg, Tine Rask Licht
Publikováno v:
Nature Microbiology
Leth, M L, Ejby, M, Workman, C, Ewald, D A, Pedersen, S S, Sternberg, C, Bahl, M I, Licht, T R, Aachmann, F L, Westereng, B & Abou Hachem, M 2018, ' Differential bacterial capture and transport preferences facilitate co-growth on dietary xylan in the human gut ', Nature Microbiology . https://doi.org/10.1038/s41564-018-0132-8
Leth, M L, Ejby, M, Workman, C, Ewald, D A, Pedersen, S S, Sternberg, C, Bahl, M I, Licht, T R, Aachmann, F L, Westereng, B & Abou Hachem, M 2018, ' Differential bacterial capture and transport preferences facilitate co-growth on dietary xylan in the human gut ', Nature Microbiology . https://doi.org/10.1038/s41564-018-0132-8
Metabolism of dietary glycans is pivotal in shaping the human gut microbiota. However, the mechanisms that promote competition for glycans among gut commensals remain unclear. Roseburia intestinalis, an abundant butyrate-producing Firmicute, is a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a935e135c4cdbfd48eea18b6bb569c85
https://hdl.handle.net/11250/2586924
https://hdl.handle.net/11250/2586924
Autor:
David Adrian Ewald, Xiangyu Peng, Yeriel Estrada, Joel Correa da Rosa, Juana Gonzalez, Emma Guttman-Yassky, James G. Krueger, Stacey R. Dillon, Xiuzhong Zheng, Benjamin Ungar, Mariya Rozenblit, Hui Xu, Mayte Suárez-Fariñas
Publikováno v:
Journal of Allergy and Clinical Immunology. 135:1218-1227
Background Genomic profiling of lesional and nonlesional skin of patients with atopic dermatitis (AD) using microarrays has led to increased understanding of AD and identification of novel therapeutic targets. However, the limitations of microarrays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcf1c9982c88a1b2a0c01b422c3e5f2
https://doi.org/10.1016/j.jaci.2015.03.003
https://doi.org/10.1016/j.jaci.2015.03.003
Autor:
Emma Guttman-Yassky, Shinji Noda, David Adrian Ewald, Margeaux Oliva, James G. Krueger, Thomas Litman, Xuan Li, Hui Xu, Kenji Kabashima, Peter Scheipers, Saeko Nakajima, Mayte Suárez-Fariñas, Tord Labuda, Christopher T. Workman, Naila Svitacheva
Publikováno v:
Ewald, D A, Noda, S, Oliva, M, Litman, T, Nakajima, S, Li, X, Xu, H, Scheipers, P, Svitacheva, N, Labuda, T, Krueger, J G, Suárez-Fariñas, M, Kabashima, K & Guttman-Yassky, E 2017, ' Major differences between human atopic dermatitis and murine models as determined by global transcriptomic profiling ', Journal of Allergy and Clinical Immunology, vol. 139, no. 2, pp. 562-571 . https://doi.org/10.1016/j.jaci.2016.08.029
Atopic dermatitis (AD) is caused by a complex interplay between immune and barrier abnormalities. Murine models of AD are essential for preclinical assessments of new treatments. While many models have been used to simulate AD, their transcriptomic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6336e4d9afb1709f49da146e224c119e
https://pubmed.ncbi.nlm.nih.gov/27702671
https://pubmed.ncbi.nlm.nih.gov/27702671