Covalent Adduct Formation as a Strategy for Efficient CO2 Fixation in Crotonyl-CoA Carboxylases/Reductases

Autor: Rodrigo Recabarren, Matthias Tinzl, David Adrian Saez, Aharon Gomez, Tobias J. Erb, Esteban Vöhringer-Martinez

Publikováno v: ACS Catalysis. 13:6230-6241

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65a14ff1e2df0334f2bdd9dd8d1fc1b1
https://doi.org/10.1021/acscatal.2c05250

Intersubunit Coupling Enables Fast CO

Autor: Hasan, DeMirci, Yashas, Rao, Gabriele M, Stoffel, Bastian, Vögeli, Kristina, Schell, Aharon, Gomez, Alexander, Batyuk, Cornelius, Gati, Raymond G, Sierra, Mark S, Hunter, E Han, Dao, Halil I, Ciftci, Brandon, Hayes, Fredric, Poitevin, Po-Nan, Li, Manat, Kaur, Kensuke, Tono, David Adrian, Saez, Samuel, Deutsch, Yasuo, Yoshikuni, Helmut, Grubmüller, Tobias J, Erb, Esteban, Vöhringer-Martinez, Soichi, Wakatsuki

Publikováno v: ACS central science. 8(8)

Enoyl-CoA carboxylases/reductases (ECRs) are some of the most efficient CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5915fda2947c222ad37cac1b99567c0
https://pubmed.ncbi.nlm.nih.gov/36032767

Evaluation of the reaction mechanism between 1,4-dihydropyridines and α,β-unsaturated nitriles

Autor: David Adrian Saez, Stefan Vogt-Geisse, Esteban Vöhringer-Martinez

Hydride transfer reactions involving 1,4-dihydropyridines play a central role in bioorganic chemistry as they represent an important share of redox metabolism. For this class of reactions, the direct hydrid transfer is the commonly accepted mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9fedbd497d03c379d4346a270c14d6c
https://doi.org/10.26434/chemrxiv-2022-68sr0

Structural adaptation of oxygen tolerance in 4-hydroxybutyrl-CoA dehydratase, a key enzyme of archaeal carbon fixation

Autor: Bradley B. Tolar, Juliana A. Murillo-López, Christopher A. Francis, Thomas Schwander, Soichi Wakatsuki, Akshaye Pal, Tzanko Doukov, Tobias J. Erb, Hasan DeMirci, David Adrian Saez, Yasuo Yoshikuni, Aldis H. Petriceks, Esteban Vöhringer-Martinez, Walter A. Rabanal-León

Publikováno v: bioRxiv-The Preprint Server for Biology

Autotrophic microorganisms that convert inorganic carbon into organic matter were key players in the evolution of life on Earth. As the early atmosphere became oxygenated, microorganisms needed to develop mechanisms for oxygen protection, especially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcee35caf5eceb1a5ef3e82618b33b4

Four amino acids define the CO2 binding pocket of enoyl-CoA carboxylases/reductases

Autor: Gabriele M. M. Stoffel, Jan Zarzycki, David Adrian Saez, Bastian Vögeli, Soichi Wakatsuki, Hasan DeMirci, Esteban Vöhringer-Martinez, Tobias J. Erb, Yashas Rao, Yasuo Yoshikuni

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 28
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences

Significance Carboxylases capture and convert CO2, which makes them key enzymes in photosynthesis and the global carbon cycle. However, the question how enzymes bind atmospheric CO2 is still unsolved. We studied enoyl-CoA carboxylases/reductases (Ecr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425a226a4e5fa5235f1e365c5aa944a0
https://escholarship.org/uc/item/4010m3wj