Zobrazeno 1 - 10
of 75
pro vyhledávání: '"David A. Zaharoff"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Breast cancer poses one of the largest threats to women’s health. Treatment continues to improve for all the subtypes of breast cancer, but some subtypes, such as triple negative breast cancer, still present a significant treatment challenge. Addit
Externí odkaz:
https://doaj.org/article/33b4661abaa846989ebd08a2afcea688
Autor:
Tai Huynh, Cassandra Reed, Zain Blackwell, Payton Phelps, Luis C. Pinzon Herrera, Jorge Almodovar, David A. Zaharoff, Jeffrey Wolchok
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract This study was designed to test the hypothesis that in addition to repairing the architectural and cellular cues via regenerative medicine, the delivery of immune cues (immunotherapy) may be needed to enhance regeneration following volumetri
Externí odkaz:
https://doaj.org/article/d8cc25e18d41491b8a5fea0dba8375ce
Autor:
Maura R. Vrabel, Jacob A. Schulman, Francis B. Gillam, Siena M. Mantooth, Khue G. Nguyen, David A. Zaharoff
Publikováno v:
Cancers, Vol 15, Iss 8, p 2210 (2023)
Focal ablation technologies are routinely used in the clinical management of inoperable solid tumors but they often result in incomplete ablations leading to high recurrence rates. Adjuvant therapies, capable of safely eliminating residual tumor cell
Externí odkaz:
https://doaj.org/article/2e6528a0cb46425881d8f0a9adcf70f2
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite the remarkable efficacy of currently approved COVID-19 vaccines, there are several opportunities for continued vaccine development against SARS-CoV-2 and future lethal respiratory viruses. In particular, restricted vaccine access and hesitanc
Externí odkaz:
https://doaj.org/article/1c9518ab0709457d94cc77dc77d7346b
Autor:
Sruthi Ravindranathan, Khue G. Nguyen, Samantha L. Kurtz, Haven N. Frazier, Sean G. Smith, Bhanu prasanth Koppolu, Narasimhan Rajaram, David A. Zaharoff
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-17 (2018)
Abstract Background Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current adjuvant therapies a
Externí odkaz:
https://doaj.org/article/3c4716e6a28d4df888466a1360de98b4
Autor:
Khue G. Nguyen, Maura R. Vrabel, Siena M. Mantooth, Jared J. Hopkins, Ethan S. Wagner, Taylor A. Gabaldon, David A. Zaharoff
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans. Ea
Externí odkaz:
https://doaj.org/article/2a102ed6a77f4157aa4fd7e3ad96d718
Autor:
Julie Eberle Davis, Ravi Kumar Gundampati, Srinivas Jayanthi, Joshua Anderson, Abigail Pickhardt, Bhanu prasanth Koppolu, David A. Zaharoff, Thallapuranam Krishnaswamy Suresh Kumar
Publikováno v:
Biochemistry and Biophysics Reports, Vol 13, Iss , Pp 45-57 (2018)
Acidic human fibroblast growth factor (hFGF1) plays a key role in cell growth and proliferation. Activation of the cell surface FGF receptor is believed to involve the glycosaminoglycan, heparin. However, the exact role of heparin is a subject of con
Externí odkaz:
https://doaj.org/article/8e6c0f7814af4fd0a6fcb6fb12ad3479
Autor:
Srinivas Jayanthi, Bhanu prasanth Koppolu, Khue G. Nguyen, Sean G. Smith, Barbara K. Felber, Thallapuranam Krishnaswamy Suresh Kumar, David A. Zaharoff
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Glycosaminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous cytokines. The aims of this multidisciplinary research were to characterize heparin binding to interleukin-12 (IL-12) and determine th
Externí odkaz:
https://doaj.org/article/e144fa0271714f01b788c20adf60ba9f
Publikováno v:
Marine Drugs, Vol 14, Iss 5, p 91 (2016)
Chitosan is a widely investigated biopolymer in drug and gene delivery, tissue engineering and vaccine development. However, the immune response to chitosan is not clearly understood due to contradicting results in literature regarding its immunoreac
Externí odkaz:
https://doaj.org/article/152c7e0cd75648aab9d4265b0324a71d
Autor:
John W. Greiner, Jeffrey Schlom, Daniel Canter, David A. Zaharoff, Connie J. Rogers, Kenneth W. Hance
Purpose: IFN-α is a pleiotropic cytokine possessing immunomodulatory properties that may improve the efficacy of therapeutic cancer vaccines. The aim of this study was to evaluate the effectiveness and compatibility of combining recombinant IFN-α w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0b3d2eb0f231afc7af1976168a6a97
https://doi.org/10.1158/1078-0432.c.6517465.v1
https://doi.org/10.1158/1078-0432.c.6517465.v1