Zobrazeno 1 - 10
of 60
pro vyhledávání: '"David A. Yurek"'
Autor:
Barbara L. Waszczak, Amirah Aly, David M. Yurek, Mark J. Cooper, Brendan Harmon, Ozge Sesenoglu-Laird, Linas Padegimas
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 16:20-33
The intranasal route of administration allows large therapeutics to circumvent the blood–brain barrier and be delivered directly to the CNS. Here we examined the distribution and pattern of cellular transfection, and the time course of transgene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e99dd926b7b0514d5a4193dec3fcd4
https://doi.org/10.1016/j.nano.2018.11.006
https://doi.org/10.1016/j.nano.2018.11.006
Autor:
David M. Yurek, Anita M. Fletcher, Matthew McShane, Tomasz H. Kowalczyk, Linas Padegimas, Marcy R. Weatherspoon, Michael D. Kaytor, Mark J. Cooper, Assem G. Ziady
Publikováno v:
Molecular Imaging, Vol 10 (2011)
In this study, we used bioluminescence imaging (BLI) to track long-term transgene activity following the transfection of brain cells using a nonviral gene therapy technique. Formulations of deoxyribonucleic acid (DNA) combined with 30-mer lysine poly
Externí odkaz:
https://doaj.org/article/74fd1eaad961438ba622f377fd517651
Autor:
David M. Yurek Ph.D., Anita M. Flectcher, Tomasz H. Kowalczyk, Linas Padegimas, Mark J. Cooper
Publikováno v:
Cell Transplantation, Vol 18 (2009)
Previously it was established that infusion of glial cell line-derived neurotrophic factor (GDNF) protein into grafts of embryonic dopamine cells has a neurotrophic effect on the grafted cells. In this study we used a nonviral technique to transfer t
Externí odkaz:
https://doaj.org/article/4e8e06173631474999fb88f01cec4ca2
Autor:
David M. Yurek, Anita Fletcher-Turner
Publikováno v:
Cell Transplantation, Vol 13 (2004)
In this study we compared the function and morphology of two types of neural grafts: allografts of fetal ventral mesencephalic (VM) tissue and xenografts of embryonic stem cell (ESC)-derived dopamine neurons. Mouse embryonic stem cells were cultured
Externí odkaz:
https://doaj.org/article/97f8e9f58733463facd590149a16d2ce
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 13:2209-2217
This study reports proof of concept for administering compacted DNA nanoparticles (DNPs) intracerebrally as a means to protect against neurotoxin-induced neurodegeneration of dopamine (DA) neurons. In this study we used DNPs that encoded for human gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb323967e4d4e826faf5a0a1ec0d15e
https://doi.org/10.1016/j.nano.2017.06.010
https://doi.org/10.1016/j.nano.2017.06.010
Publikováno v:
Cell Transplantation, Vol 10 (2001)
Fibroblasts derived from the Rat2 parental cell line were genetically modified to express the cell-associated form of Sonic hedgehog (Shh) and then co-grafted along with E14 fetal ventral mesencephalon (VM) tissue into the denervated striatum of F344
Externí odkaz:
https://doaj.org/article/aa10ab8ef1ed4444ae5449bf016c1bd3
Autor:
Anita Fletcher, Kristine S. Ziemba, Chen Zhang, David M. Yurek, Biswarup Ghosh, George M. Smith
Publikováno v:
Molecular Therapy. Methods & Clinical Development
The overall goal of our research is to establish a preformed molecular guidance pathway to direct the growth of dopaminergic axons from embryonic ventral mesencephalon (VM), tissue placed within the substantia nigra (SN), into the striatum to reconst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb552e9bf95f87a669a8d67151b38fd
https://pubmed.ncbi.nlm.nih.gov/31417940
https://pubmed.ncbi.nlm.nih.gov/31417940
Autor:
Mark J. Cooper, Linas Padegimas, Wayne A. Cass, David M. Yurek, Ulla Hasselrot, Ozge Sesenoglu-Laird
Publikováno v:
Neuroscience. 284:500-512
In previous studies that used compacted DNA nanoparticles (DNP) to transfect cells in the brain, we observed higher transgene expression in the denervated striatum when compared to transgene expression in the intact striatum. We also observed that lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3127009f2c8328b57a40e57b09813b69
https://doi.org/10.1016/j.neuroscience.2014.10.026
https://doi.org/10.1016/j.neuroscience.2014.10.026
Autor:
Jian Wang, Michael Gregory Bell, Ming-Shang Kuo, James Schrementi, James McGee, Mark C. Kowala, David A Yurek, Lan Yu
Publikováno v:
Analytical Biochemistry. 462:44-50
Aldosterone plays a key role in the pathogenesis of hypertension, congestive heart failure, and chronic kidney disease. Aldosterone biosynthesis involves three membrane-bound enzymes: aldosterone synthase, adrenodoxin, and adrenodoxin reductase. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5a8bdb4f0fd1a0c470920b37938867
https://doi.org/10.1016/j.ab.2014.06.011
https://doi.org/10.1016/j.ab.2014.06.011
Autor:
Chen Zhang, E. Truit, Anita M. Fletcher, Kristine S. Ziemba, George M. Smith, Ying Jin, Biswarup Ghosh, David M. Yurek
Publikováno v:
Experimental Neurology. 250:156-164
Different experimental and clinical strategies have been used to promote survival of transplanted embryonic ventral mesencephalic (VM) neurons. However, few studies have focused on the long-distance growth of dopaminergic axons from VM transplants. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be62c06c3aaf386278b146354fe092b6
https://doi.org/10.1016/j.expneurol.2013.09.022
https://doi.org/10.1016/j.expneurol.2013.09.022