Zobrazeno 1 - 10
of 2 825
pro vyhledávání: '"David A. Young"'
Autor:
Rodolfo Gómez, Matt J. Barter, Ana Alonso-Pérez, Andrew J. Skelton, Carole Proctor, Gabriel Herrero-Beaumont, David A. Young
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-17 (2023)
Abstract Background Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the relationship between genomic regions subject to DNA-methylation changes du
Externí odkaz:
https://doaj.org/article/d05b15634531419289d5e5b613947160
Autor:
Matt J. Barter, Andrew Butcher, Hui Wang, Dimitra Tsompani, Martin Galler, Ellen L. Rumsby, Kirsty L. Culley, Ian M. Clark, David A. Young
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Elevated pro-inflammatory signalling coupled with catabolic metalloproteinase expression is a common feature of arthritis, leading to cartilage damage, deterioration of the joint architecture and the associated pain and immobility. Counterin
Externí odkaz:
https://doaj.org/article/b236eceb3e654db68f7631e1b411f044
Autor:
Dan J. Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Hua Lin, Yao Hao, Colin G. Miles, Dimitra Tsompani, Robert M. Jackson, Michael D. Briggs, Katarzyna A. Piróg, Ian M. Clark, Matt J. Barter, Gavin J. Clowry, Fiona E. N. LeBeau, David A. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules. Individual microRNAs have the ability to specifically target a wide array of gene t
Externí odkaz:
https://doaj.org/article/b74a1a1210eb465eb49f8ba80fb52c10
Autor:
Matt J Barter, Kathleen Cheung, Julia Falk, Andreas C Panagiotopoulos, Caitlin Cosimini, Siobhan O’Brien, Karina Teja-Putri, Graham Neill, David J Deehan, David A. Young
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 106-119 (2021)
Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression. Inflammatory cytokine stimulation of cells can cause rapid gene expression changes through di
Externí odkaz:
https://doaj.org/article/f3384607721b41a5a198673cf0f7c3ea
Autor:
Linh Le, Lingzi Niu, Matthew J. Barter, David A. Young, Tamas Dalmay, Ian M. Clark, Tracey E. Swingler
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract MicroRNAs have been shown to play a role in cartilage development, homeostasis and breakdown during osteoarthritis. We previously identified miR-3085 in humans as a chondrocyte-selective microRNA, however it could not be detected by Northern
Externí odkaz:
https://doaj.org/article/cfc83db974f44c4a99653de7ef60af7c
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 594-603 (2020)
DNA methylation of CpG sites is commonly measured using Illumina Infinium BeadChip platforms. The Infinium MethylationEPIC array has replaced the Infinium Methylation450K array. The two arrays use the same technology, with the EPIC array assaying alm
Externí odkaz:
https://doaj.org/article/df1f7d28e78143c3a7cc6a6f2d4c6408
Publikováno v:
Applied Sciences, Vol 11, Iss 13, p 6231 (2021)
Alloys expand or contract as concentrations change, and the resulting relationship between atomic volume and alloy content is an important property of the solid. While a well-known approximation posits that the atomic volume varies linearly with conc
Externí odkaz:
https://doaj.org/article/07b2a2d6be4a4ce982fd15482fddd93b
Publikováno v:
F1000Research, Vol 8 (2019)
Metalloproteinases remain important players in arthritic disease, in part because members of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are responsible for the irreversible degradation of articular cartilage co
Externí odkaz:
https://doaj.org/article/0564a8575466481c86baa31437de9133
Autor:
Xinmi Huo, Kok Haur Ong, Kah Weng Lau, Laurent Gole, David M. Young, Char Loo Tan, Xiaohui Zhu, Chongchong Zhang, Yonghui Zhang, Longjie Li, Hao Han, Haoda Lu, Jing Zhang, Jun Hou, Huanfen Zhao, Hualei Gan, Lijuan Yin, Xingxing Wang, Xiaoyue Chen, Hong Lv, Haotian Cao, Xiaozhen Yu, Yabin Shi, Ziling Huang, Gabriel Marini, Jun Xu, Bingxian Liu, Bingxian Chen, Qiang Wang, Kun Gui, Wenzhao Shi, Yingying Sun, Wanyuan Chen, Dalong Cao, Stephan J. Sanders, Hwee Kuan Lee, Susan Swee-Shan Hue, Weimiao Yu, Soo Yong Tan
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-13 (2024)
Abstract Background Artificial Intelligence(AI)-based solutions for Gleason grading hold promise for pathologists, while image quality inconsistency, continuous data integration needs, and limited generalizability hinder their adoption and scalabilit
Externí odkaz:
https://doaj.org/article/c5026c6f9d9540348f7717c223adff6f
Autor:
Joo Kyung Park, Hyoung-oh Jeong, Hyemin Kim, Jin Ho Choi, Eun Mi Lee, Seunghoon Kim, Jinho Jang, David Whee-Young Choi, Se-Hoon Lee, Kyoung Mee Kim, Kee-Taek Jang, Kwang Hyuck Lee, Kyu Taek Lee, Min Woo Lee, Jong Kyun Lee, Semin Lee
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background Intratumoral heterogeneity (ITH) and tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) play important roles in tumor evolution and patient outcomes. However, the precise characterization of diverse cell popul
Externí odkaz:
https://doaj.org/article/f7e91e3225c14813a26af18da590a5ed