Zobrazeno 1 - 10
of 100
pro vyhledávání: '"David A. Vincent"'
Autor:
Oberkirsch, Laurin, Zanger, David Amos Vincent, Maldonado Quinto, Daniel, Schwarzbözl, Peter, Hoffschmidt, Bernhard
Publikováno v:
In Solar Energy 1 May 2023 255:327-338
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gundaz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor sign
Externí odkaz:
https://doaj.org/article/685f337608c24440b7e084866104173a
Autor:
Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and infla
Externí odkaz:
https://doaj.org/article/e406c430dd004d04b04b4ed7f56f1c67
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d890b609d092453794d4b110a230e27b
Publikováno v:
Reproductive Biology and Endocrinology, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Transforming growth factor beta (TGFB) superfamily signaling is implicated in the development of sex cord-stromal tumors, a category of poorly defined gonadal tumors. The aim of this study was to determine potential effects of dys
Externí odkaz:
https://doaj.org/article/a8ba40923a3e4063996361593ab1745c
Autor:
Nicolas Chuvin, David F. Vincent, Roxane M. Pommier, Lindsay B. Alcaraz, Johann Gout, Cassandre Caligaris, Karam Yacoub, Victoire Cardot, Elodie Roger, Bastien Kaniewski, Sylvie Martel, Celia Cintas, Sophie Goddard-Léon, Amélie Colombe, Julie Valantin, Nicolas Gadot, Emilie Servoz, Jennifer Morton, Isabelle Goddard, Anne Couvelard, Vinciane Rebours, Julie Guillermet, Owen J. Sansom, Isabelle Treilleux, Ulrich Valcourt, Stéphanie Sentis, Pierre Dubus, Laurent Bartholin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 2, Pp 263-282 (2017)
Background & Aims: Transforming growth factor beta (TGFβ) acts either as a tumor suppressor or as an oncogene, depending on the cellular context and time of activation. TGFβ activates the canonical SMAD pathway through its interaction with th
Externí odkaz:
https://doaj.org/article/e49cd12ee88d4e9a90e40577438a5e07
Autor:
Channing J. Der, Antje Schaefer, Christine Sers, Owen J. Sansom, Robert S. Sandler, Alan P. Fields, Adrienne D. Cox, Michael S. Lee, Jen Jen Yeh, Temitope O. Keku, Catriona A. Ford, Andrew D. Campbell, Priya S. Hibshman, Andrew M. Waters, Philipp Jurmeister, Armin Jarosch, David F. Vincent, Karen A. Pickering, Verline Justilien, Dimitri G. Trembath, Gabriela H. Loeza, Joseph A. Galanko, Timothy D. Martin, Melissa Kang, Danielle R. Cook
Supplementary Tables and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716f1ec775b2149c51d25ed6b40d85e7
https://doi.org/10.1158/0008-5472.22430088.v1
https://doi.org/10.1158/0008-5472.22430088.v1
Autor:
Channing J. Der, Antje Schaefer, Christine Sers, Owen J. Sansom, Robert S. Sandler, Alan P. Fields, Adrienne D. Cox, Michael S. Lee, Jen Jen Yeh, Temitope O. Keku, Catriona A. Ford, Andrew D. Campbell, Priya S. Hibshman, Andrew M. Waters, Philipp Jurmeister, Armin Jarosch, David F. Vincent, Karen A. Pickering, Verline Justilien, Dimitri G. Trembath, Gabriela H. Loeza, Joseph A. Galanko, Timothy D. Martin, Melissa Kang, Danielle R. Cook
ECT2 is an activator of RHO GTPases that is essential for cytokinesis. In addition, ECT2 was identified as an oncoprotein when expressed ectopically in NIH/3T3 fibroblasts. However, oncogenic activation of ECT2 resulted from N-terminal truncation, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39df620acc21559580a1176438fb783a
https://doi.org/10.1158/0008-5472.c.6513543.v1
https://doi.org/10.1158/0008-5472.c.6513543.v1
Autor:
Channing J. Der, Antje Schaefer, Christine Sers, Owen J. Sansom, Robert S. Sandler, Alan P. Fields, Adrienne D. Cox, Michael S. Lee, Jen Jen Yeh, Temitope O. Keku, Catriona A. Ford, Andrew D. Campbell, Priya S. Hibshman, Andrew M. Waters, Philipp Jurmeister, Armin Jarosch, David F. Vincent, Karen A. Pickering, Verline Justilien, Dimitri G. Trembath, Gabriela H. Loeza, Joseph A. Galanko, Timothy D. Martin, Melissa Kang, Danielle R. Cook
Supplementary Figures S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583ed68e747b4fc91add4c2b36d07c3e
https://doi.org/10.1158/0008-5472.22430085
https://doi.org/10.1158/0008-5472.22430085
Autor:
Laurent Bartholin, Stéphanie Sentis, Ulrich Valcourt, Alain Puisieux, Stéphane Ansieau, Caroline Moyret-Lalle, Pascal Bernard, Geneviève Fourel, Guillaume Devailly, Bastien Kaniewski, Sylvie Martel, Vanessa Arfi, Nicolas Chuvin, Lindsay B. Alcaraz, David F. Vincent, Johann Gout, Roxane M. Pommier
Inactivation of Tif1γ in spontaneously immortalized mouse embryonic fibroblasts rapidly results in cell cycle blockade in G2/M phases, spindle checkpoint activation and mitotic catastrophe events.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055ca147c8a3066ea076a907a2cf7e3b
https://doi.org/10.1158/0008-5472.22404647.v1
https://doi.org/10.1158/0008-5472.22404647.v1