Zobrazeno 1 - 10
of 393
pro vyhledávání: '"David A. Thornton"'
Autor:
Eamon Dubaissi, Emma N. Hilton, Sarah Lilley, Richard Collins, Charlotte Holt, Peter March, Henry Danahay, Martin Gosling, Richard K Grencis, Ian S Roberts, David J Thornton
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms. While TMEM16A is associated with increased mu
Externí odkaz:
https://doaj.org/article/862848294a45463c8ad8b0615eb98903
Autor:
Alexander R. Bennett, Iris Mair, Andrew Muir, Hannah Smith, Larisa Logunova, Andrew Wolfenden, Jonathan Fenn, Ann E. Lowe, Janette E. Bradley, Kathryn J. Else, David J. Thornton
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Mucin protein glycosylation is important in determining biological properties of mucus gels, which form protective barriers at mucosal surfaces of the body such as the intestine. Ecological factors including: age, sex, and diet can change mu
Externí odkaz:
https://doaj.org/article/ac89f561e69d45c38002ffb7599e043b
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0306058 (2024)
Mucosal-delivered drugs have to pass through the mucus layer before absorption through the epithelial cell membrane. Although there has been increasing interest in polymeric mucins, a major structural component of mucus, potentially acting as importa
Externí odkaz:
https://doaj.org/article/976c5176187a41b4a60b30cdc424519b
Autor:
Jeremy A. Herrera, Lewis A. Dingle, M. Angeles Monetero, Rajamiyer V. Venkateswaran, John F. Blaikley, Felice Granato, Stella Pearson, Craig Lawless, David J. Thornton
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Honeycombing is a histological pattern consistent with Usual Interstitial Pneumonia (UIP). Honeycombing refers to cystic airways located at sites of dense fibrosis with marked mucus accumulation. Utilizing laser capture microdissection coupl
Externí odkaz:
https://doaj.org/article/4bf7214b4b0e498ebb0d2bd16a5899df
Autor:
Anita L. Hansen, Gina Ambroziak, David M. Thornton, James C. Mundt, Rachel E. Kahn, Lisbeth Dahl, Leif Waage, Daniel Kattenbraker, Bjørn Grung
Publikováno v:
Food & Nutrition Research, Vol 67, Pp 1-13 (2023)
Background: Nutritional interventions may serve as a stress resilience strategy with important implications for human health. Objective: The aim of this study was to investigate the effect of vitamin D supplementation throughout wintertime on problem
Externí odkaz:
https://doaj.org/article/7dbc276a3c634feaa8d13b332117ce2f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Cyclic peptides are good candidates for orally delivered therapeutics, however, issues remain in their development due to low intestinal permeability. Although some of the biological factors have been reported that regulate intestinal permea
Externí odkaz:
https://doaj.org/article/2063075387d247ef9bb4fa2bd6ca903a
Autor:
María A. Duque-Correa, David Goulding, Faye H. Rodgers, J. Andrew Gillis, Claire Cormie, Kate A. Rawlinson, Allison J. Bancroft, Hayley M. Bennett, Magda E. Lotkowska, Adam J. Reid, Anneliese O. Speak, Paul Scott, Nicholas Redshaw, Charlotte Tolley, Catherine McCarthy, Cordelia Brandt, Catherine Sharpe, Caroline Ridley, Judit Gali Moya, Claudia M. Carneiro, Tobias Starborg, Kelly S. Hayes, Nancy Holroyd, Mandy Sanders, David J. Thornton, Richard K. Grencis, Matthew Berriman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Whipworms are large parasites causing chronic disease in humans and other mammals. Here, the authors show how larvae create tunnels inside the gut lining and reveal the early host response to infection via Isg15 in mice and murine caecaloids.
Externí odkaz:
https://doaj.org/article/86da51cf01e849638b4d23641665bd5e
Autor:
Leslie E. Morgan, Ana M. Jaramillo, Siddharth K. Shenoy, Dorota Raclawska, Nkechinyere A. Emezienna, Vanessa L. Richardson, Naoko Hara, Anna Q. Harder, James C. NeeDell, Corinne E. Hennessy, Hassan M. El-Batal, Chelsea M. Magin, Diane E. Grove Villalon, Gregg Duncan, Justin S. Hanes, Jung Soo Suk, David J. Thornton, Fernando Holguin, William J. Janssen, William R. Thelin, Christopher M. Evans
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
In asthma, mucus plugging is an important cause of airflow obstruction, but it is not targeted by widely used bronchodilator and anti-inflammatory drugs. Here the authors show that reduction of disulfide bonds that hold mucin polymers together revers
Externí odkaz:
https://doaj.org/article/2fb68d67a4a24797aac17403bb6726b1
Autor:
Allison J. Bancroft, Colin W. Levy, Thomas A. Jowitt, Kelly S. Hayes, Seona Thompson, Edward A. Mckenzie, Matthew D. Ball, Eamon Dubaissi, Aidan P. France, Bruno Bellina, Catherine Sharpe, Aleksandr Mironov, Sheila L. Brown, Peter C. Cook, Andrew S. MacDonald, David J. Thornton, Richard K. Grencis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm
Externí odkaz:
https://doaj.org/article/e790a9921fd644c2949b6cd1e5687605
Publikováno v:
Journal of Cystic Fibrosis. 22:S23-S26
Cystic fibrosis (CF), an autosomal genetic disorder caused by the dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, is characterized by mucus accumulation in the lungs, the intestinal tract, and the pancreatic duc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2756e618460aac9c53045ada570f70d
https://doi.org/10.1016/j.jcf.2022.08.019
https://doi.org/10.1016/j.jcf.2022.08.019