Zobrazeno 1 - 10
of 122
pro vyhledávání: '"David A. Thorley-Lawson"'
Autor:
Karen A Duca, Michael Shapiro, Edgar Delgado-Eckert, Vey Hadinoto, Abdul S Jarrah, Reinhard Laubenbacher, Kichol Lee, Katherine Luzuriaga, Nicholas F Polys, David A Thorley-Lawson
Publikováno v:
PLoS Pathogens, Vol 3, Iss 10, Pp 1388-1400 (2007)
The possibility of using computer simulation and mathematical modeling to gain insight into biological and other complex systems is receiving increased attention. However, it is as yet unclear to what extent these techniques will provide useful biolo
Externí odkaz:
https://doaj.org/article/0f4643fed2444e4b9406e75f024d8293
Publikováno v:
PLoS Pathogens, Vol 11, Iss 1, p e1004561 (2015)
The human herpes virus Epstein-Barr virus (EBV) latently infects and drives the proliferation of B lymphocytes in vitro and is associated with several forms of lymphoma and carcinoma in vivo. The virus encodes ~30 miRNAs in the BART region, the funct
Externí odkaz:
https://doaj.org/article/2204f44d52614f7d83fd3a4352c81624
Autor:
Charles Torgbor, Peter Awuah, Kirk Deitsch, Parisa Kalantari, Karen A Duca, David A Thorley-Lawson
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004170 (2014)
Endemic Burkitt's lymphoma (eBL) arises from the germinal center (GC). It is a common tumor of young children in tropical Africa and its occurrence is closely linked geographically with the incidence of P. falciparum malaria. This association was not
Externí odkaz:
https://doaj.org/article/780747a2f5a74f7c9e08d94d1631bf9b
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003685 (2013)
Previous analysis of Epstein-Barr virus (EBV) persistent infection has involved biological and immunological studies to identify and quantify infected cell populations and the immune response to them. This led to a biological model whereby EBV infect
Externí odkaz:
https://doaj.org/article/d5dbd684ae2e4a31ab4e788bfb0546a3
Autor:
Jin Qiu, Katherine Cosmopoulos, Michiel Pegtel, Erik Hopmans, Paul Murray, Jaap Middeldorp, Michael Shapiro, David A Thorley-Lawson
Publikováno v:
PLoS Pathogens, Vol 7, Iss 8, p e1002193 (2011)
We have performed the first extensive profiling of Epstein-Barr virus (EBV) miRNAs on in vivo derived normal and neoplastic infected tissues. We describe a unique pattern of viral miRNA expression by normal infected cells in vivo expressing restricte
Externí odkaz:
https://doaj.org/article/b26f0e6d23a74156b9b7c71786d198c0
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27650 (2011)
Germinal centers (GCs) are complex dynamic structures that form within lymph nodes as an essential process in the humoral immune response. They represent a paradigm for studying the regulation of cell movement in the development of complex anatomical
Externí odkaz:
https://doaj.org/article/14cb1a700e514ba6b1417beaaa5a7191
Publikováno v:
PLoS Pathogens, Vol 5, Iss 7, p e1000496 (2009)
To develop more detailed models of EBV persistence we have studied the dynamics of virus shedding in healthy carriers. We demonstrate that EBV shedding into saliva is continuous and rapid such that the virus level is replaced in < or =2 minutes, the
Externí odkaz:
https://doaj.org/article/5ee303e5c21f49d1b825530203199c8c
Publikováno v:
Current Opinion in Virology. 3:227-232
Epstein-Barr virus (EBV) maintains a lifelong infection. According to the germinal center model (GCM), latently infected B cells transit the germinal center (GC) to become resting memory cells. Here, the virus resides quiescently, occasionally reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f42a303a6e5f475b7be93403c6bfca
https://doi.org/10.1016/j.coviro.2013.04.005
https://doi.org/10.1016/j.coviro.2013.04.005
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005331 (2016)
PLoS Pathogens
PLoS Pathogens
The link between Plasmodium falciparum malaria and endemic Burkitt’s lymphoma (eBL) has been an enigma for more than 50 years, since it was first observed that the occurrence of the two coincided [1,2]. So convincing was the association that it led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524e2d1ab9288b948778ad7296c71e10
http://europepmc.org/articles/PMC4721646?pdf=render
http://europepmc.org/articles/PMC4721646?pdf=render
Autor:
David A. Thorley-Lawson, Shalyn Catherine Clute, Franco Celada, Nuray Aslan, John L. Sullivan, Levi B. Watkin, Katherine Luzuriaga, Roberto Puzone, Raymond M. Welsh, Yuri N. Naumov, Liisa K. Selin
Publikováno v:
The Journal of Immunology. 185:6753-6764
Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a process known as heterologous immunity. Because a challenge virus epitope may react with only a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6bcfca70dc329ad1d4974cae7e3137b
https://doi.org/10.4049/jimmunol.1000812
https://doi.org/10.4049/jimmunol.1000812