Zobrazeno 1 - 10
of 226
pro vyhledávání: '"David A. Spiller"'
Autor:
Liam Feltham, Josephine Moran, Marie Goldrick, Elizabeth Lord, David G. Spiller, Jennifer S. Cavet, Mark Muldoon, Ian. S. Roberts, Pawel Paszek
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Dissemination of food-borne L. monocytogenes in the host relies on internalin-mediated invasion, but the underlying invasion strategies remain elusive. Here we use live-cell microscopy to follow single cell interactions between individual human cells
Externí odkaz:
https://doaj.org/article/6f37f87fb20348498905d94b4d73c328
Autor:
Josephine Moran, Liam Feltham, James Bagnall, Marie Goldrick, Elizabeth Lord, Catherine Nettleton, David G. Spiller, Ian Roberts, Pawel Paszek
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Pathogens have developed intricate strategies to overcome the host’s innate immune responses. In this paper we use live-cell microscopy with a single bacterium resolution to follow in real time interactions between the food-borne pathogen L. monocy
Externí odkaz:
https://doaj.org/article/69fdee6a62aa4abfa1029b6156b2163f
Autor:
Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm in some cell types. We i
Externí odkaz:
https://doaj.org/article/0ae9f541650a4de1829a089cf962e69c
Autor:
Eirini Kalliara, Malgorzata Kardynska, James Bagnall, David G. Spiller, Werner Müller, Dominik Ruckerl, Jarosław Śmieja, Subhra K. Biswas, Pawel Paszek
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune cells fine tune their responses to infection and inflammatory cues. Here, using live-cell confocal microscopy and mathematical modelling, we investigate interferon-induced JAK-STAT signalling in innate immune macrophages. We demonstrate that t
Externí odkaz:
https://doaj.org/article/f18214bc8b124365b6050d91ca9f4e00
Autor:
Alex A Koch, James S Bagnall, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon
Publikováno v:
eLife, Vol 11 (2022)
The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu
Externí odkaz:
https://doaj.org/article/12909e7319834f59a2d8e05b4469036f
Autor:
Anna Paszek, Małgorzata Kardyńska, James Bagnall, Jarosław Śmieja, David G. Spiller, Piotr Widłak, Marek Kimmel, Wieslawa Widlak, Pawel Paszek
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-21 (2020)
Abstract Background Ability to adapt to temperature changes trough the Heat Shock Response (HSR) pathways is one of the most fundamental and clinically relevant cellular response systems. Heat Shock (HS) affects the signalling and gene expression res
Externí odkaz:
https://doaj.org/article/758c2e93f16345e197d175e447dfcac2
Autor:
Timothy J. Thurman, Todd M. Palmer, Jason J. Kolbe, Arash M. Askary, Kiyoko M. Gotanda, Oriol Lapiedra, Tyler R. Kartzinel, Naomi Man in’t Veld, Liam J. Revell, Johanna E. Wegener, Thomas W. Schoener, David A. Spiller, Jonathan B. Losos, Robert M. Pringle, Rowan D. H. Barrett
Publikováno v:
The American Naturalist. 201:537-556
Autor:
Cerys S. Manning, Veronica Biga, James Boyd, Jochen Kursawe, Bodvar Ymisson, David G. Spiller, Christopher M. Sanderson, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
The single-cell gene expression changes during spinal cord formation and neurogenesis in mice are unclear. Here, the authors use a HES5 reporter to live image, then mathematically model, oscillations in single cells in presumed progenitors and neuron
Externí odkaz:
https://doaj.org/article/625df354e8904d6d8d48ca404cd12312
Autor:
Nan Yang, Nicola J Smyllie, Honor Morris, Cátia F Gonçalves, Michal Dudek, Dharshika R J Pathiranage, Johanna E Chesham, Antony Adamson, David G Spiller, Egor Zindy, James Bagnall, Neil Humphreys, Judith Hoyland, Andrew S I Loudon, Michael H Hastings, Qing-Jun Meng
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008729 (2020)
Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the principal co-ordina
Externí odkaz:
https://doaj.org/article/43fa25b09c644bd38b2e46c67b3637c5
Autor:
Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using a lentivirus approach,
Externí odkaz:
https://doaj.org/article/d581931c5d434a78a70223703dfa1143